Patents Assigned to Board of Regents, The University of Texas
  • Publication number: 20220298484
    Abstract: Disclosed are methods for restoring stem cell properties to stem cells in need thereof. Stem cells that have diminished or substantially no stem cell properties are cultivated on extracellular matrix that is produced by cells that are capable of producing CCN1/Cyr61 to produce a rescued stem cell culture. The rescued stem cell culture exhibits restored stem cell properties including responsiveness to differentiation inducers and/or adipogenesis inducers. The rescued stem culture can be used in autologous stem cell based therapies.
    Type: Application
    Filed: June 4, 2020
    Publication date: September 22, 2022
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Xiao-Dong CHEN, MIlos MARINKOVIC
  • Publication number: 20220296511
    Abstract: In some aspects, the present disclosure provides pharmaceutical compositions comprising particles, wherein individual particles of the composition comprise a combination of two or more active pharmaceutical ingredients selected from: (A) nintedanib; (B) pirfenidone; and/or (C) mycophenolic acid. These compositions may be formulated for administration via inhalation. In some aspects, the present disclosure provides methods for preparing the pharmaceutical compositions of the present disclosure and methods of treating or preventing a disease or disorder using the pharmaceutical compositions of the present disclosure.
    Type: Application
    Filed: March 18, 2022
    Publication date: September 22, 2022
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Robert O. WILLIAMS III, Jay I. PETERS, Tuangrat PRAPHAWATVET, Sawittree SAHAKIJPIJARN, Chaeho MOON
  • Publication number: 20220296102
    Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for minimally invasive collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.
    Type: Application
    Filed: November 5, 2021
    Publication date: September 22, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: Livia Schiavinato Eberlin, Thomas Milner, Jialing Zhang, Noah Giese, Nitesh Katta
  • Patent number: 11448103
    Abstract: In one embodiment, an electromagnetic soft actuator includes a first soft outer member comprising a soft internal electrically conductive coil, a second soft outer member comprising a soft internal electrically conductive coil, and a soft inner shaft on which the first and second soft outer members are mounted, the first and second soft outer members being linearly displaceable along a length of the soft inner shaft, the soft inner shaft comprising a permanent magnet, wherein the first and second outer members linearly move under an electromagnetic force relative to the soft inner shaft and each other when an electric current is applied to the soft internal electrically conductive coils.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: September 20, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Amir Jafari, Nafiseh Ebrahimi
  • Patent number: 11447830
    Abstract: Methods for identifying and treating cancers that are DNA repair, such as homologous recombination (HR) repair, defective or sensitive to PARP inhibitors or platinum-based therapy. In some aspects, DNA repair, such as HR repair, defective cancers are treated with a PARP inhibitor therapy or cisplatin. Methods for sensitizing cancers to a PARP inhibitor therapy are also provided.
    Type: Grant
    Filed: March 5, 2018
    Date of Patent: September 20, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Shiaw-Yih Lin, Daniel McGrail, Gordon Mills
  • Patent number: 11446302
    Abstract: The present disclosure provides methods of treating cancer in a patient determined to have an EGFR and/or HER2 exon 20 mutation, such as an insertion mutation, by administering a third-generation tyrosine kinase inhibitor, such as poziotinib or afatinib.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: September 20, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Jacqulyne Robichaux, Monique Nilsson, John V. Heymach
  • Patent number: 11447593
    Abstract: Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R? is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.
    Type: Grant
    Filed: March 10, 2020
    Date of Patent: September 20, 2022
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Jinming Gao, David Boothman, Kejin Zhou, Xiaonan Huang, Yiguang Wang
  • Patent number: 11448033
    Abstract: A wellbore isolation device includes a mandrel, a sealing element disposed around at least a portion of the mandrel, and a delay coating disposed on at least a portion of an outer surface of the sealing element. The sealing element includes a swellable material and the delay coating covers a cross-linked polymer. The delay coating is configured to swell or degrade in a wellbore fluid.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: September 20, 2022
    Assignees: HALLIBURTON ENERGY SERVICES, INC., BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Michael Linley Fripp, Xiaoguang Allan Zhong, Kejia Yang, Walter Voit, Nelson Yan Loo Lee, Yong Dai Tan, Bing Hong Chee, Ee Wen Wong
  • Patent number: 11449658
    Abstract: A method can be executed by at least one processor of a computer to generate synthetic Integrated Circuit (IC) layout patterns, where the method can optionally include accessing attribute values of the IC layout pattern features generated using IC layout patterns from at least one at least one previous generation semiconductor fabrication technology node.
    Type: Grant
    Filed: November 12, 2019
    Date of Patent: September 20, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Gaurav Rajavendra Reddy, Mohammad M. Bidmeshki, Georgios Makris
  • Patent number: 11448965
    Abstract: Disclosed herein are methods for patterning two-dimensional atomic layer materials, the methods comprising: illuminating a first location of an optothermal substrate with electromagnetic radiation, wherein the optothermal substrate converts at least a portion of the electromagnetic radiation into thermal energy, and wherein the optothermal substrate is in thermal contact with a two-dimensional atomic layer material; thereby: generating an ablation region at a location of the two-dimensional atomic layer material proximate to the first location of the optothermal substrate, wherein at least a portion of the ablation region has a temperature sufficient to ablate at least a portion of the two-dimensional atomic layer material within the ablation region, thereby patterning the two-dimensional atomic layer material. Also disclosed herein are systems for performing the methods described herein, patterned two-dimensional atomic layer materials made by the methods described herein and methods of use thereof.
    Type: Grant
    Filed: July 22, 2019
    Date of Patent: September 20, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Yuebing Zheng, Linhan Lin, Jingang Li
  • Publication number: 20220294450
    Abstract: A magneto-electric (ME) inverter includes two anti-ferromagnetic spin orbit read (AFSOR) circuit elements, each AFSOR circuit element has a CMOS inverter; and an AFSOR device with a ME base layer; a semiconductor channel layer on the ME base layer and comprising a source terminal and a drain terminal, where the source terminal is coupled to an output of the CMOS inverter; and a gate electrode on the semiconductor channel layer. The gate electrode of a second AFSOR device of the two AFSOR circuit elements is coupled to the drain terminal of a first AFSOR device of the two AFSOR circuit elements.
    Type: Application
    Filed: May 29, 2022
    Publication date: September 15, 2022
    Applicants: Board of Regents of the University of Nebraska, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Intel Corporation
    Inventors: Nishtha Sharma GAUL, Andrew MARSHALL, Peter A. DOWBEN, Dmitri E. NIKONOV
  • Publication number: 20220288404
    Abstract: A method of treating a tumor in a subject, the method comprises delivering an ATR inhibitor to the tumor, and applying a tumor treating field to the tumor at a frequency between approximately 50 kHz and approximately 1,000 kHz.
    Type: Application
    Filed: March 11, 2022
    Publication date: September 15, 2022
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Michael D. STORY, Narasimha Kumar KARANAM
  • Publication number: 20220288121
    Abstract: Provided herein are cryopreservation compositions and methods for cells of any kind, including for cells for adoptive cell therapy that are off-the-shelf cells. The cells for cryopreservation may be expanding NK cells expressing chimeric antigen receptors. In specific cases, the cryopreservation media comprises a cryoprotectant, such as DMSO, glycerol or hydroxyethol starch; serum or a non-serum alternative, such as platelet lysate; and one or more cytokines that are either natural, modified, synthetic, or recombinant.
    Type: Application
    Filed: August 25, 2020
    Publication date: September 15, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: Katy REZVANI, Enli LIU, Elizabeth SHPALL, Rafet BASAR, David MARIN COSTA
  • Publication number: 20220288335
    Abstract: A pharyngeal tube for establishing an airway within a patient may comprise an elongated hollow tube including a proximal end and a distal end. A mouthpiece may be provided at the proximal end of the tube, and one or more lateral openings may be provided at or near the distal end of the hollow tube. The one or more lateral openings may be formed in a lateral wall of the hollow tube, and a distal tip of the hollow tube is sealed so that air cannot escape the tube from its distal tip. The mouthpiece may form an airtight seal at the patients mouth. The mouthpiece may include an inner flange configured to be positioned between the patients teeth and lips, and an outer flange configured to be positioned on the outside of the patients lips. Some variations of the hollow tube may further include an inner septum that divides the tube into first and second lumens that are connected at the distal end of the tube.
    Type: Application
    Filed: September 3, 2020
    Publication date: September 15, 2022
    Applicant: Board of Regents of the University Texas System
    Inventor: Yandong Jiang
  • Publication number: 20220294449
    Abstract: A magneto-electric (ME) majority gate device includes a conducting device and a plurality of ME transistors coupled to the conducting device. In one implementation, the plurality of ME transistors include a ME AND gate device with downward interface polarization, a ME-transmission gate device with downward interface polarization, and a ME-XNOR gate device. In another implementation, the plurality of ME transistors is five single-input ME-FETs.
    Type: Application
    Filed: May 29, 2022
    Publication date: September 15, 2022
    Applicants: Board of Regents of the University of Nebraska, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Intel Corporation
    Inventors: Nishtha Sharma GAUL, Andrew MARSHALL, Peter A. DOWBEN, Dmitri E. NIKONOV
  • Publication number: 20220294448
    Abstract: A magneto-electric (ME) XNOR logic gate device includes a conducting device; and a ME-FET coupled to the conducting device. The ME-FET can be formed of a split gate; a first gate terminal coupled to a first portion of the split gate for receiving a first input signal; a second gate terminal coupled to a second portion of the split gate for receiving a second input signal; a source terminal coupled to a ground line; and a drain terminal coupled to the conducting device.
    Type: Application
    Filed: May 29, 2022
    Publication date: September 15, 2022
    Applicants: Board of Regents of the University of Nebraska, BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Intel Corporation
    Inventors: Nishtha Sharma GAUL, Andrew MARSHALL, Peter A. DOWBEN, Dmitri E. NIKONOV
  • Patent number: 11439650
    Abstract: Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.
    Type: Grant
    Filed: May 5, 2020
    Date of Patent: September 13, 2022
    Assignees: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, DISPERSOL TECHNOLOGIES, LLC
    Inventors: Chris Brough, James W. McGinity, Dave A. Miller, James C. DiNunzio, Robert O. Williams, III
  • Patent number: 11440317
    Abstract: In an embodiment, a method for controlling a printer is provided. The method includes: receiving a set of parameters associated with a printer by a computing device, wherein the printer is depositing ink on a substrate to generate a line; measuring a width of the line by the computing device; receiving a duty cycle associated with the printer by the computing device; using the received duty cycle, the set of parameters, and a model, estimating one or more unknown parameters of the set of parameters by the computing device; receiving a desired width of the line by the computing device; and if the desired width is not the same as the measured width: adjusting the duty cycle associated with the printer based on the set of parameters and the model so that the measured width is closer to the desired width by the computing device.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: September 13, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Nicholas R. Gans, Bashir H. Jafari
  • Publication number: 20220281961
    Abstract: The present disclosure in various aspects provides methods for making pharmaceutical compositions for treating neurodegenerative diseases (e.g., demyelinating diseases), such as but not limited to multiple sclerosis, neuromyelitis optica, and transverse myelitis. The pharmaceutical compositions impact specific antibody-mediated processes involved in the biology of neurodegenerative disease. In certain aspects, the disclosure provides pharmaceutical compositions for treating neurodegenerative disease, which are based on inhibiting the action of pathologic antibodies, or alternatively providing antibodies to stimulate neuroprotection or repair processes.
    Type: Application
    Filed: May 12, 2017
    Publication date: September 8, 2022
    Applicant: The Board of Regents of the University of Texas System
    Inventor: Nancy MONSON
  • Patent number: 11435358
    Abstract: Identifying proteins and peptides, and more specifically large-scale sequencing of single peptides in a mixture of diverse peptides at the single molecule level is an unmet challenge in the field of protein sequencing. Herein are methods for identifying amino acids in peptides, including peptides with unnatural amino acids. In one embodiment, the N-terminal amino acid is labeled with a first label and an internal amino acid is labeled with a second label. In some embodiments, the labels are fluorescent labels. In other embodiments, the internal amino acid is Lysine. In other embodiments, amino acids in peptides are identified based on the fluorescent signature for each peptide at the single molecule level.
    Type: Grant
    Filed: October 1, 2021
    Date of Patent: September 6, 2022
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Edward Marcotte, Eric V. Anslyn, Andrew Ellington, Jagannath Swaminathan