Abstract: A system and method of processing seismic data obtained using a surface-based receiver configured to measure vertical movement of the Earth includes retrieving seismic data from a storage device, the seismic data comprising P-P data and shear mode data. The P-P data and shear mode data were both received at a surface-based receiver configured to measure vertical movement of the Earth to generate the seismic data. The system and method further include processing the seismic data to extract the shear mode data and generating a shear mode image based on the extracted shear mode data.

Abstract: Indwelling medical apparatus including one optoacoustic discernible member or a plurality of optoacoustic discernible members and methods for optoacoustic guidance and confirmation of placement of optoacoustically discernible indwelling medical apparatus.

Abstract: The present invention includes methods of making and methods of using peptidomimetics compositions that mimic ?-helical BH3 sequences in cells. The peptidomimetics can be used to mimic ?-helical BH3 sequences and kill cancer cells.

Abstract: The invention provides, in a general sense, a new labeling strategy employing 99mTc chelated with ethylenedicysteine (EC). EC is conjugated with a variety of ligands and chelated to 99mTc for use as an imaging agent for tissue-specific diseases. The drug conjugates of the invention may also be used as a prognostic tool or as a tool to deliver therapeutics to specific sites within a mammalian body. Kits for use in tissue-specific disease imaging are also provided.

Abstract: Apparatuses and methods for the production of superfine fibers.

Abstract: The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic antibody:antigen complex, soluble antigen and soluble therapeutic antibody, wherein a patient has undergone at least one course of immunotherapy. Yet further, levels of therapeutic antibody:antigen complexes, soluble antigens or soluble therapeutic antibodies may be measured and used to stage or monitor a hyperproliferative disease.

Abstract: Embodiments of the present invention comprise a guidance system and method for providing an angular orientation of a medical device. The system and method may utilize a fluid-filled portion with a position indicator that floats in the fluid contained within the fluid-filled portion. The guidance system may be coupled to the medical device so that when the angular orientation of the guidance system is varied, the position indicator moves within the fluid-filled portion. The position of the position indicator is designated by angle gradations on the outer portion of the fluid-filled portion.

Abstract: The present invention relates to diagnostic and therapeutic nanoparticles. More particularly, the present invention relates to creating a copper (Cu)-based nanoparticle and a method for making the same. The Cu-based nanoparticles can further be incorporated with additional therapeutic or diagnostic compounds and used for the diagnosis and treatment of tumors.

Abstract: The claimed invention uses activated carbon fibers that incorporate porous carbon with a suitable pore size to maximize capacitance. The porous carbon material is prepared using a template, followed by incorporation into a matrix polymer and electrospinning of the mixture. Subsequent thermal treatments retain the fiber form, and a composite carbon fiber incorporating templated porous carbon is attained. The resulting electrode is binder free and 100% electrochemically active. Energy densities up to 41 Wh/kg in energy density 1.5 kW/kg in power density (electrode weight only) have been achieved.

Abstract: An apparatus and method for accelerating Java translation are provided. The apparatus includes a lookup table which stores an lookup table having arrangements of bytecodes and native codes corresponding to the bytecodes, a decoder which generates pointer to the native code corresponding to the feed bytecode in the lookup table, a parameterized bytecode processing unit which detects parameterized bytecode among the feed bytecode, and generating pointer to native code required for constant embedding in the lookup table, a constant embedding unit which embeds constants into the native code with the pointer generated by the parameterized bytecode processing unit, and a native code buffer which stores the native code generated by the decoder or the constant embedding unit.

Abstract: The invention is directed to shape memory polymer compositions, articles of manufacture thereof, and methods of preparation and use thereof. The invention is further directed to methods of controlling the nature of the interaction of a shape memory device with the environment in which it is operating.

Abstract: A novel contrast mechanism for diagnosing diseased tissue using Ultrasound, Doppler Ultrasonography, Optical Coherence Tomography, or optical Doppler tomography coupled with an externally applied temporally oscillating high-strength magnetic field.

Abstract: The development and application of a novel non-polar oil recovery process utilizing a non-dispersive solvent extraction method to coalesce and recover oil from a lysed or non-lysed Yeast slurry using a microporous hollow fiber (MHF) membrane contactor.

Abstract: Gene expression can be selectively regulated by endogenous miRNAs that target promoters of genes. Altering of the activity of these promoter-targeting miRNAs with single-stranded complementary oligonucleotides that bind the miRNA causes modulation of expression of the target gene. Endogenous miRNAs that modulate expression of target genes can be identified by (a) evaluating an endogenous miRNA for complementarity to a target gene promoter; and (b) determining that the complementary miRNA modulates expression of the target gene.

Abstract: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status in a patient. In particular, it has been found that the biomarkers set forth in Table 1 are biomarkers for ovarian cancer. The biomarkers can be detected by SELDI mass spectrometry.

Abstract: Liquid nebulizer apparatus, systems, and formulation compositions, as well as systems for the nebulized, aerosol delivery of such compositions, for the administration and insufflation of medicinal aerosols into the pulmonary system of a mammal are described. The nebulizing apparatus and system can effectively aerosolize a variety of viscosities of medicinal liquid drug carriers, including those made up of oil, water, or emulsions of oil and water. Drugs dissolved or suspended in the compositions and formulations described and adapted for use herein are not damaged or denatured by the nebulization process when the nebulizer described is used. Further, the nebulization system itself can be adapted for use with both mechanically assisted pulmonary ventilation systems as well as hand-held inhalers and nose/mouth face masks for use in pulmonary drug delivery.

Abstract: A method of making an injectable or implantable active agent delivery device capable of delivering a diagnostic, therapeutic, and/or prophylactic agent to a desired targeted site having orifice(s) on the surface is disclosed herein providing unidirectional release of the agent at a controlled desirable rate. The agent may include, but is not limited to, drugs, proteins, peptides, biomarkers, bioanalytes, and/or genetic material. The technology of the invention is based on parallel processing to fabricate micro-holes on tubes employing photo-lithography and reactive ion etching techniques and also incorporates a simple molding method to form the micro-holes on flexible polymer tubes, including bio-degradable tubes. The parallel processing method of the instant invention is fast, economical and well suited for mass production. The developed device, due to its composite structure, has the ability to combine several release mechanisms, leading to zero-order release kinetics for most of the time.

Abstract: A device and method for heart performance characterization and abnormality detection is disclosed herein. The device and method analyze and characterize cardiac electrophysiological signals which help in the diagnosis of myocardial ischemia in advance of a heart attack.

Abstract: A composition comprising a powder mixture of potassium citrate and calcium citrate as mixtures of pure chemical salts and methods of making and using the composition are disclosed. The composition is useful for the treatment and prevention of kidney stones and osteoporosis and better delivers potassium and calcium than commonly used potassium and calcium supplements.

Abstract: Vertical cavity light emitting sources that utilize patterned membranes as reflectors are provided. The vertical cavity light emitting sources have a stacked structure that includes an active region disposed between an upper reflector and a lower reflector. The active region, upper reflector and lower reflector can be fabricated from single or multi-layered thin films of solid states materials (“membranes”) that can be separately processed and then stacked to form a vertical cavity light emitting source.