Abstract: Provided herein are methods and devices for the detection of analytes. The methods employ particles formed from a first metal conjugated to analytes. The analyte conjugated to the particle formed from the first metal can be accumulated at a working electrode. The first metal can be galvanically exchanged with ions of a second metal to form a layer of the first metal at the working electrode. The first metal can then be electrochemically detected and/or quantified. Using this method, analytes can be detected at low concentrations a few femtomolar via anodic stripping voltammetry, with no washing steps or electrode modifications.

Abstract: An apparatus and method for measuring the superposition of a plurality of sound waves propagating within a conduit containing a fluid having a plurality of transducers positioned substantially parallel to the flow direction along the wall of the conduit. The system includes a computing device for modeling the superposition of a plurality of sound waves as they propagate within the conduit.

Abstract: A system for measuring the superposition of a plurality of sound waves propagating within a conduit containing a fluid having a plurality of transducers positioned substantially parallel to the flow direction along the wall of the conduit. The system includes means for modeling the superposition of a plurality of sound waves as they propagate within the conduit.

Abstract: The present invention includes methods of making and methods of using peptidomimetics compositions that mimic ?-helical BH3 sequences in cells. The peptidomimetics can be used to mimic ?-helical BH3 sequences and kill cancer cells.

Abstract: The present invention discloses a device and methods for characterizing vulnerable plaque and cancer tissue by measuring changes in tissue elasticity compared to that of normal tissue. The system includes a catheter with an expandable element at a proximal end. The expandable element is equipped with pressure sensors to detect changes in tissue elasticity and can be additionally equipped with sensors that detect tissue temperature and pH. For arterial tissue or tissue lining a body cavity, the device can also be equipped with width gauges that measure the diameter of the artery lumen or the width of any section of the body cavity. The distal end of the catheter may be attached to a motorized pullback device connected to a computer. Data collected by the device sensors are sent to the computer for processing and analysis.