Patents Assigned to Board of Regents, The University Texas System
  • Methods and devices related to toehold-based strand displacement with loop-mediated isothermal amplification
    Patent number: 10913973
    Abstract: Disclosed are compositions and methods for isothermal nucleic acid amplification and detection.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: February 9, 2021
    Assignee: Board of Regents, The University Texas System
    Inventors: Andrew Ellington, Yu Sherry Jiang, Sanchita Bhadra, Bingling Li, Randy Allen Hughes, Yan Du, Jimmy Gollihar
  • Recombinant materials for production of a protein toxic to fire ants
    Patent number: 6551800
    Abstract: A nucleic acid derived from Bacillus thuringiensis contains a nucleotide sequence that encodes a polypeptide demonstrated to be toxic to fire ants.
    Type: Grant
    Filed: October 24, 2000
    Date of Patent: April 22, 2003
    Assignee: The Board of Regents, The University Texas System
    Inventors: Lee A. Bulla, Jr., Mehmet Candas
  • Troglitazone compounds for treating climacteric and cancer
    Patent number: 6207690
    Abstract: The present invention is directed toward the use of the drug Troglitazone and related thiazolidinedione compounds in the treatment of the climacteric and cancer. This use is based on the novel discovery that Troglitazone inhibits steroidogenesis in granulosa cell cultures. This activity is believed to result from the ability of thiazolidinedione derivatives to act as a ligand for the orphan steroid receptor peroxisome proliferator-activated receptor gamma (PPAR&ggr;). Troglitazone and related compounds can therefore be used to prevent excessive uterine bleeding during. Further, enhanced translocation of this orphan nuclear receptor into the nucleus of cells will block transcription in rapidly proliferating cancer cells that express PPAR&ggr;, resulting in loss of cell viability.
    Type: Grant
    Filed: September 3, 1999
    Date of Patent: March 27, 2001
    Assignee: Board of Regents, The University Texas System
    Inventors: Randall J. Urban, Allan Green
  • Diamine platinum(IV) complexes having mixed carboxylate ligands as antitumor agents
    Patent number: 5288887
    Abstract: Platinum(IV) complexes with mixed carboxylato ligands having the formula: ##STR1## where X.sup.1 and X.sup.2 are carboxylato, or are jointly dicarboxylato, where .sup.1 Y and Y.sup.2 are carboxylato, and where Z is either diaminocyclohexane or ethylenediamine, have been found to have desirable antitumor activity, as well as relatively low levels of toxicity.
    Type: Grant
    Filed: November 19, 1992
    Date of Patent: February 22, 1994
    Assignee: Board of Regents, The University Texas System
    Inventors: Abdul R. Khokhar, Zahid H. Siddik, Salaam Al-Baker