Abstract: Certain non-nucleoside compounds that will selectively inhibit telomerase by targeting the nucleic add structures, such as G-quadruplexes, that may be associated with human telomeres or telomerase have been identified. Inhibition of human telomerase by two perylenetetracarboxylic acid diimides and a carbocyanine has been demonstrated. 1H-NMR studies have evidenced the stabilization of a G-quadruplex by the perylenetetracarboxylic acid diimide compounds and provided evidence that these and structurally related compounds inhibit the telomerase enzyme by a mechanism consistent with interaction with G-quadruplex structures.
Type:
Application
Filed:
December 5, 2000
Publication date:
August 8, 2002
Applicant:
Board of Regents, The Universty of Texas System
Inventors:
Sean M. Kerwin, Oleg Y. Fedoroff, Miguel Salazar, Laurence H. Hurley