Patents Assigned to Board of Regents University of Nebraska
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Patent number: 11963945Abstract: Described are methods of treating or preventing a virus in a subject comprising administering ozonides to the subject.Type: GrantFiled: January 6, 2022Date of Patent: April 23, 2024Assignees: THE JOHNS HOPKINS UNIVERSITY, BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKAInventors: Ravit Boger, Jonathan Vennerstrom
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Patent number: 11950867Abstract: Disclosed herein are various robotic surgical devices and systems that include first and second elongate bodies, first and second driveshafts disposed through the second elongate body, and an in-line shoulder joint with a robotic arm coupled thereto. In certain implementations, the in-line shoulder joint has a differential yoke and a dual shaft disposed within the yoke lumen.Type: GrantFiled: November 4, 2022Date of Patent: April 9, 2024Assignee: Board of Regents of the University of NebraskaInventors: Joseph Palmowski, Shane Farritor
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Patent number: 11951227Abstract: Coated and expanded, nanofiber structures are provided and methods of use thereof.Type: GrantFiled: April 4, 2022Date of Patent: April 9, 2024Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKAInventors: Jingwei Xie, Shixuan Chen, Mark Carlson
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Patent number: 11946164Abstract: Expanded, nanofiber structures are provided as well as methods of use thereof and methods of making.Type: GrantFiled: July 19, 2022Date of Patent: April 2, 2024Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKAInventor: Jingwei Xie
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Publication number: 20240096493Abstract: Aspects of the present disclosure relate to systems and methods for analyzing a tumor, and more specifically, analyzing a tumor to identify a biological aggressiveness of the tumor. One example method for tumor analysis includes: receiving one or more input features associated with a geometric shape of a tumor, the one or more input features including at least a value indicating a circularity of the tumor; determining, via a machine learning component, a characteristic of the tumor based on the one or more input features, the characteristic being indicative of patient survivability; and outputting an indication of the characteristic.Type: ApplicationFiled: September 18, 2023Publication date: March 21, 2024Applicants: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKAInventors: Matteo Ligorio, Rebecca Napier, William Gasper, Dario Ghersi
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Patent number: 11934039Abstract: A surgical loupes head strap is disclosed. The surgical loupes head strap may include a first monofilament and a second monofilament coupled by at least one sleeve. The surgical loupes head strap may further include a first coupler with a first hole and a second hole, where the first hole is configured to surround and couple to a first end of the first monofilament, and the second hole is configured to surround and couple to at least a portion of a first surgical loupes headgear temple. The surgical loupes head strap may further include a second coupler with a first hole and a second hole, where the first hole is configured to surround and couple to a first end of the second monofilament, and the second hole is configured to surround and couple to at least a portion of a second surgical loupes headgear temple.Type: GrantFiled: January 16, 2019Date of Patent: March 19, 2024Assignee: Board of Regents of the University of NebraskaInventors: Donny Suh, James Hermsen
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Patent number: 11911117Abstract: A number of improvements are provided relating to computer aided surgery utilizing an on tool tracking system. The various improvements relate generally to both the methods used during computer aided surgery and the devices used during such procedures. Other improvements relate to the structure of the tools used during a procedure and how the tools can be controlled using the OTT device. Still other improvements relate to methods of providing feedback during a procedure to improve either the efficiency or quality, or both, for a procedure including the rate of and type of data processed depending upon a CAS mode.Type: GrantFiled: September 4, 2022Date of Patent: February 27, 2024Assignee: Board of Regents of the University of NebraskaInventors: Hani Haider, Ibrahim Al-Shawi, Osvaldo Andres Barrera
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Patent number: 11911464Abstract: Anti-parasitic compounds and uses thereof. Compounds comprising a C-terminal peptide adjuvant conjugated to an N-terminal peptide antigen via a protease-cleavable linker, said peptide adjuvant comprising a peptide analog of C5a, wherein said peptide antigen comprises an antigenic epitope of a parasitic organism, such as T. gondii. Methods of therapeutic or prophylactic treatment of a parasitic infections.Type: GrantFiled: September 13, 2019Date of Patent: February 27, 2024Assignees: Prommune, Inc., Board of Regents of the University of NebraskaInventors: Paul Davis, Samer Al-Murrani
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Patent number: 11909576Abstract: Various medical devices and related systems, including robotic and/or in vivo medical devices, and various robotic surgical devices for in vivo medical procedures. Included herein, for example, is a robotic surgical system having a support beam positionable through an incision, and a robotic device having a device body, first and second rotating shoulder components coupled to the device body, and first and second robotic arms coupled to the first and second shoulder components, respectively.Type: GrantFiled: January 24, 2023Date of Patent: February 20, 2024Assignee: Board of Regents of the University of NebraskaInventors: Shane Farritor, Tyler Wortman, Kyle Strabala, Ryan McCormick, Amy Lehman, Dmitry Oleynikov, Eric Markvicka
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Publication number: 20240050735Abstract: Systems and methods for treating and inhibiting wound infections employ a hydrogel ionic circuit (HIC)-based device for therapeutic iontophoresis and/or biofilm debridement. The HIC-based device includes: a first chamber containing a salt solution; a second chamber containing a therapeutic or buffer solution, the second chamber being configured to interface with a surface overlaying a target region; a hydrogel membrane separating the first chamber from the second chamber; and an electrode configured to apply an electrical current to the first chamber of the working device to induce an ion current in the salt solution, wherein the ion current acts on the second chamber to iontophoretically transport therapeutic molecules across the surface overlaying the target region and/or debride biofilm at the surface overlaying the target region.Type: ApplicationFiled: October 25, 2023Publication date: February 15, 2024Applicant: Board of Regents of the University of NebraskaInventors: Siwei Zhao, Fan Zhao
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Patent number: 11896423Abstract: Technology is described that can be used for continuous measurements of blood pressure and arterial blood flow to automatically derive time-varying estimates of multiple factors pertaining to a patient's vascular system. Such factors can include, but are not limited to, resistive flow, capacitive flow, vascular resistance, and arterial capacitance. Determination of such factors can allow for the meaningful assessment of the control of vascular resistance and capacitance in real time.Type: GrantFiled: March 28, 2022Date of Patent: February 13, 2024Assignee: Board of Regents of the University of NebraskaInventors: Irving H. Zucker, Ioannis Chatzizisis, Han-Jun Wang, Alicia M. Schiller, Peter Ricci Pellegrino
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Patent number: 11883065Abstract: The various embodiments herein relate to systems, devices, and/or methods relating to surgical procedures, and more specifically for accessing an insufflated cavity of a patient and/or positioning surgical systems or devices into the cavity.Type: GrantFiled: August 21, 2020Date of Patent: January 30, 2024Assignee: Board of Regents of the University of NebraskaInventors: Thomas Frederick, Shane Farritor, Jack Mondry, Eric Markvicka, Dmitry Oleynikov, Jacob Greenburg
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Patent number: 11857265Abstract: A number of improvements are provided relating to computer aided surgery. The improvement relates to both the methods used during computer aided surgery and the devices used during such procedures. Some of the improvement relate to controlling the selection of which data to display during a procedure and/or how the data is displayed to aid the surgeon. Other improvements relate to the structure of the tools used during a procedure and how the tools can be controlled automatically to improve the efficiency of the procedure. Still other improvements relate to methods of providing feedback during a procedure to improve either the efficiency or quality, or both, for a procedure.Type: GrantFiled: December 23, 2022Date of Patent: January 2, 2024Assignee: Board of Regents of the University of NebraskaInventors: Hani Haider, Osvaldo Andres Barrera
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Patent number: 11857443Abstract: Some implementations of an endovascular device include a stent graft with an expandable tubular metallic frame and a covering material disposed on at least a portion of the metallic frame. The stent graft defines a lumen therethrough. In a particular embodiment, a first balloon is disposed around an outer periphery of the stent graft, a second balloon is disposed around the outer periphery of the stent graft and spaced apart from the first balloon, and a third balloon is disposed within the stent graft lumen between the first balloon and the second balloon. The third balloon can be inflated to fully or partially occlude the lumen. The first and second balloons can be individually inflated to fully or partially shunt blood flow from a blood vessel through the stent graft. In some embodiments, sensors and an automated control unit are included to automate the operations of the endovascular device.Type: GrantFiled: July 29, 2020Date of Patent: January 2, 2024Assignee: Board of Regents of the University of NebraskaInventors: Jason N. MacTaggart, Alexey Kamenskiy
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Patent number: 11839623Abstract: The present invention provides prodrugs and methods of use thereof.Type: GrantFiled: January 14, 2019Date of Patent: December 12, 2023Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKAInventors: Howard E. Gendelman, Benson Edagwa
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Patent number: 11840540Abstract: Provided herein are compounds and methods for modulating the NF?B pathway. More particularly, provided are inhibitors of the NF?B pathway and the uses of such inhibitors in regulating diseases and disorders, e.g., to treat cancer, autoimmune diseases, inflammatory diseases, diabetes, cardiovascular diseases, or neurological diseases.Type: GrantFiled: July 21, 2021Date of Patent: December 12, 2023Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKAInventors: Amarnath Natarajan, Sandeep Rana
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Publication number: 20230390382Abstract: Disclosed herein are methods, systems, compositions and strategies for the creation and use WW-domain-Activated Extracellular Vesicles (WAEVs) for presenting HIV antigen domains. These WAEVs can be harnessed to deliver and present HIV antigens useful for vaccine development. Specifically, the disclosure provides a fusion protein comprising: (a) a WW-containing domain; (b) a transmembrane domain; and (c) an extracellular domain, wherein the extracellular domain is an HIV antigen domain. Further provided are sequences of each domain as well as methods of producing and using the fusion protein.Type: ApplicationFiled: October 15, 2021Publication date: December 7, 2023Applicants: President and Fellows of Harvard College, Board of Regents of the University of NebraskaInventors: Quan Lu, Shi-Hua Xiang
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Patent number: 11832871Abstract: The embodiments disclosed herein relate to various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices, and more specifically including end effectors that can be incorporated into such devices. Certain end effector embodiments include various vessel cautery devices that have rotational movement as well as cautery and cutting functions while maintaining a relatively compact structure. Other end effector embodiments include various end effector devices that have more than one end effector.Type: GrantFiled: June 21, 2021Date of Patent: December 5, 2023Assignee: Board of Regents of the University of NebraskaInventors: Shane Farritor, Tom Frederick, Joe Bartels
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Patent number: 11819299Abstract: Disclosed herein are various medical device components, including components that can be incorporated into robotic and/or in vivo medical devices. Also disclosed are various medical devices for in vivo medical procedures. Included herein, for example, is a surgical robotic device having an elongate device body, a right robotic arm coupled to a right shoulder assembly, and a left robotic arm coupled to a left shoulder assembly.Type: GrantFiled: November 28, 2022Date of Patent: November 21, 2023Assignee: Board of Regents of the University of NebraskaInventors: Jack Mondry, Shane Farritor, Eric Markvicka, Thomas Frederick, Joe Bartels
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Patent number: D1006248Type: GrantFiled: March 23, 2022Date of Patent: November 28, 2023Assignee: Board of Regents of the University of NebraskaInventors: Thang Nguyen, Michael Wadman, Wesley Zeger