Patents Assigned to Board of Regents, University of Texas System
  • Patent number: 10447271
    Abstract: Memristor-based dividers using memristors-as-drivers (MAD) gates. As a result of employing MAD gates in memristor-based dividers, such as binary non-restoring dividers and SRT dividers, the number of delay steps may be less than half than the number of delay steps required in traditional CMOS implementations of dividers. Furthermore, by using MAD gates, memristor-based dividers can be implemented with less complexity (e.g., fewer memristors and drivers). As a result, by the memristor-based dividers using MAD gates, the speed and complexity of a wide variety of arithmetic operations is improved.
    Type: Grant
    Filed: April 15, 2019
    Date of Patent: October 15, 2019
    Assignee: Board of Regents, The University of Texas System
    Inventors: Earl Swartzlander, Lauren Guckert
  • Patent number: 10442852
    Abstract: Methods and compositions are provided for the treatment of a patient with intracranial hemorrhage (ICH). Methods include the use of the products of recombinant constructs such as those that contain lactoferrin, as well as fusion protein constructs of lactoferrin and Fc domain for IgG.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: October 15, 2019
    Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Marian L. Kruzel, Jaroslaw Aronowski
  • Patent number: 10446845
    Abstract: The present disclosure provides a rechargeable electrochemical cell including an electrolyte side, a cathode side, and a polymer/plasticizer. The electrolyte side includes a solid glass electrolyte including an electrolyte mobile cation and electric dipoles, as well as an anode including a metal of the electrolyte mobile cation and contacting the solid glass electrolyte at an anode:solid glass electrolyte interface. The cathode side includes a cathode including a cathode active material into which a cathode guest cation is reversibly extracted/inserted. The cathode active material has a voltage versus lithium (Li) metal of between 3V and 15V. The polymer/plasticizer contacts the solid glass electrolyte at a solid glass electrolyte:polymer/plasticizer interface and the cathode at a polymer/plasticizer:cathode interface such that the cathode guest cation is confined to the cathode side and the electrolyte mobile cation is confined to the anode side during charge and discharge of the electrochemical cell.
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: October 15, 2019
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: John B. Goodenough, Maria Helena Sousa Soares De Oliveira Braga
  • Patent number: 10442911
    Abstract: The present invention includes a hydrogel and a method of making a porous hydrogel by preparing an aqueous mixture of an uncrosslinked polymer and a crystallizable molecule; casting the mixture into a vessel; allowing the cast mixture to dry to form an amorphous hydrogel film; seeding the cast mixture with a seed crystal of the crystallizable molecule; growing the crystallizable molecule into a crystal structure within the uncrosslinked polymer; crosslinking the polymer around the crystal structure under conditions in which the crystal structure within the crosslinked polymer is maintained; and dissolving the crystals within the crosslinked polymer to form the porous hydrogel.
    Type: Grant
    Filed: February 7, 2018
    Date of Patent: October 15, 2019
    Assignee: Board of Regents, The University of Texas System
    Inventors: Scott Zawko, Christine Schmidt
  • Patent number: 10441607
    Abstract: In some aspects, the present disclosure provides compositions comprising an N4-based MMC ligand, a cell targeting group, and a fluorophore or a therapeutic compound comprising a formula: wherein the variables are as defined herein. In some embodiments, these compositions may be used in the imaging techniques or in the treatment of a disease or disorder such as cancer.
    Type: Grant
    Filed: February 22, 2017
    Date of Patent: October 15, 2019
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Ali Azhdarinia, Sukhen C. Ghosh, Nathaniel L. Wilganowski, Eva M. Sevick-Muraca
  • Publication number: 20190307406
    Abstract: Radiation therapy systems and their components, including secondary radiation shields. At least some versions of the disclosed systems combine a radiation delivery device, a primary radiation shielding device, and a secondary shielding layer into an integrated, modular unit. This is accomplished by using a small direct beam shield capable of blocking a primary beam from a radiation delivery device. In turn, a thinner shielding layer can be used to surround the radiation delivery device and primary shielding device, enabling a single modular unit to be delivered to an installation site. In some embodiments, a bed may be disposed within the secondary shielding layer. In some embodiments, the system is configured to provide up to 4-pi (4?) steradians of radiation coverage to the bed from the radiation delivery device.
    Type: Application
    Filed: June 17, 2019
    Publication date: October 10, 2019
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Hak CHOY, Steve Jiang, Robert Timmerman, Arnold Pompos
  • Publication number: 20190307107
    Abstract: Aspects of the disclosure relate to a composition comprising 20-60% w/w of fat combined with a nitric oxide synthase inhibitor. Method aspects of the disclosure relate to a method for inducing heart failure with preserved ejection fraction in an experimental laboratory animal, the method comprising administering a composition of the disclosure or a composition comprising 10-60% w/w of fat and a composition comprising a nitric oxide synthase inhibitor to the laboratory animal.
    Type: Application
    Filed: June 12, 2017
    Publication date: October 10, 2019
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Joseph A HILL, Gabriele G SCHIATTARELLA, Thomas G GILLETTE
  • Patent number: 10434063
    Abstract: The present invention provides, in some aspects, bilayered and trilayered pharmaceutical implant compositions for the unidirectional delivery of anti-cancer compounds to the brain over a period of time (e.g., several weeks, 1, 2, 3, 4, 5, 6, 7 days, or 1, 2, 3, weeks, or any range derivable therein) following the removal of glioblastoma multiforme or other malignant tumors in the brain.
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: October 8, 2019
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Michael J. McGinity, Feng Zhang, John R. Floyd, James W. McGinity
  • Patent number: 10434062
    Abstract: The present invention includes compositions and methods for treating and delivering medicinal formulations using an inhaler. The composition includes a space filled flocculated suspension having one or more flocculated particles of one or more active agents and a hydrofluoroalkane propellant. A portion of the one or more flocculated particles is templated by the formation of hydrofluoroalkane droplets upon atomization and the templated floc compacts upon the evaporation of the hydrofluoroalkane propellant to form a porous particle for deep lung delivery.
    Type: Grant
    Filed: August 29, 2018
    Date of Patent: October 8, 2019
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Keith P. Johnston, Joshua Engstrom, Jasmine Rowe, Alan B. Watts, Robert O. Williams, III
  • Patent number: 10433861
    Abstract: In some embodiments, a method of ameliorating diastolic dysfunction may include positioning at least a distal end of a system for cutting a trabeculae carneae in a left ventricle of a human heart. The system may include an elongated member, a grip, an engaging portion, and a cutting device. A second end of the engaging portion may turn in upon the engaging portion towards a first end of the engaging portion while still allowing trabeculae carneae to enter through an opening between the first and second ends. The cutting device may be positioned within an inner diameter of the engaging portion. The method may include positioning at least one trabeculae carneae in the inner diameter of the engaging portion. The method may include severing the at least one trabeculae carneae. The method may include increasing left ventricular compliance of the human heart.
    Type: Grant
    Filed: August 27, 2014
    Date of Patent: October 8, 2019
    Assignee: Board of Regents of the University of Texas System
    Inventors: Marc D. Feldman, Daniel Escobedo, David L. Halaney, Jordan C. Dwelle, Austin B. McElroy, Thomas E. Milner
  • Patent number: 10434221
    Abstract: Biodegradable antimicrobial films are provided that are solid at room temperature and substantially liquefy in situ after implantation into a mammal, such as a human patient. Methods of using the films to cover a medical device, such as a breast implant, prior to insertion into a subject are also provided.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: October 8, 2019
    Assignee: Board of Regents, The University of Texas System
    Inventors: Joel Rosenblatt, Issam Raad, Andrew P. Dennis
  • Patent number: 10433872
    Abstract: The present invention includes a system, kit and apparatus to aid in the realignment of one or more bones of a patient. The present invention provides a substantially rigid orthopedic stabilization scaffold for attachment of one or more external fixators for the realignment of one or more bones of a patient. The orthopedic stabilization scaffold includes a first anchorable frame and a second anchorable frame that are removably attachable to an operating table and connected adjustably by one or more crossbars.
    Type: Grant
    Filed: May 20, 2013
    Date of Patent: October 8, 2019
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventor: Adam Starr
  • Patent number: 10434075
    Abstract: Embodiments of the current invention include methods and compositions for treating breast cancer by administering an effective amount of MJC13 to a subject in need thereof.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: October 8, 2019
    Assignees: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, THE REGENTS OF THE UNIVERSITY OF COLORADO
    Inventors: Marc B. Cox, Jennifer Richer
  • Patent number: 10435821
    Abstract: The invention is directed to melt-processable carbon fiber precursors which have the capability of thermal stabilization in air followed by carbonization in inert atmosphere which make them cost effective and widen their applications.
    Type: Grant
    Filed: February 14, 2015
    Date of Patent: October 8, 2019
    Assignees: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, KOREA INSTITUTE OF CARBON CONVERGENCE TECHNOLOGY
    Inventors: Duck J. Yang, Benjamin Batchelor, Samsuddin Faisal Mahmood, Dennis W. Smith, Wenjin Deng, Hyunkyu Shin, Minhye Jung
  • Patent number: 10435430
    Abstract: Described are compounds and methods useful for the treatment and investigation of diseases and disorders associated with expanded repeat-containing RNA molecules. In certain embodiments, compounds and methods useful for the modulation of ATXN-3 pre-mRNA are described. In certain embodiments, compounds and methods useful for the modulation of ATN-1 mRNA are described.
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: October 8, 2019
    Assignees: IONIS PHARMACEUTICALS, INC., THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Thazha P. Prakash, Jiaxin Hu, Jing Liu, Dongbo Yu, David Corey, Eric E. Swayze
  • Patent number: 10437648
    Abstract: A method, system and computer program product for load balancing of graph processing workloads. Synthetic proxy graphs are generated to characterize machines' graph processing speeds in a cluster. Each of the graph applications executing in the cluster is profiled using the synthetic graphs to form profiling sets. These formed profiling sets are run among the machines in the cluster to capture the machines' graph processing speeds. A metric for each of the graph applications is computed from a relative speedup among the machines in the cluster and/or the graph processing speeds. A graph file of a natural graph and a graph application are loaded. A metric out of the computed metrics is selected based on the graph application. The natural graph is then partitioned into multiple chunks which is distributed onto two or more machines in the cluster based on the selected metric and a user selected partitioning algorithm.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: October 8, 2019
    Assignee: Board of Regents, The University of Texas System
    Inventors: Lizy Kurian John, Shuang Song, Andreas Gerstlauer
  • Publication number: 20190298997
    Abstract: An apparatus for monitoring a patient post operation having electrically conducting leads which are adapted to extend from inside the patient. The leads having electrodes adapted to communicate with a heart of the patient and apply electrical signals to the heart. The electrodes providing cardiac signals to the computer in response to the electrical signals so the computer can determine in real time at least one of heart volume, end diastolic heart volume, end systolic heart volume, stroke volume, change in heart volume, change in stroke volume, contractility, respiration rate or tidal volume regarding the patient.
    Type: Application
    Filed: July 12, 2017
    Publication date: October 3, 2019
    Applicant: Board of Regents, The University of Texas System
    Inventors: Jonathan W. Valvano, John A. Pearce, Marc D. Feldman, Kaarthik Rajendran, John Porterfield, Anil Kottam, Wes Johnson
  • Publication number: 20190298751
    Abstract: The present disclosure provide for methods of using 6-thio-2?-deoxyguanosine (6-thio-dG) to treat telomerase-positive cancers that exhibit (a) one or more TERT promoter mutations, and/or (b) enriched telomere transcriptional signature(s). In particular, melanomas, including those who are not sensitive or have become resistant to immune checkpoint inhibition and/or MAPKi therapy are targets for this therapy.
    Type: Application
    Filed: May 26, 2017
    Publication date: October 3, 2019
    Applicants: The Board of Regents of the University of Texas System, The Wistar Institute of Anatomy and Biology
    Inventors: Jerry W. SHAY, Gao ZHANG
  • Publication number: 20190305158
    Abstract: Described are flexible electronics incorporating a bacterial cellulose paper substrate and methods of making and using the flexible electronics. Example devices disclosed include photovoltaic cells constructed over bacterial cellulose paper substrates.
    Type: Application
    Filed: September 27, 2017
    Publication date: October 3, 2019
    Applicant: Board of Regents, The University of Texas System
    Inventors: Brian A. Korgel, Vikas Reddy Voggu, James Sham, R. Malcolm Brown, Taylor B. Harvey
  • Patent number: 10428159
    Abstract: Provided herein are monoclonal antibodies that recognize, bind to, and block interactions of other molecules with AGR2 and C4.4A. Also provided herein are methods of using anti-AGR2 and anti-C4.4A antibodies to treat cancer.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: October 1, 2019
    Assignee: Board of Regents, The University of Texas System
    Inventors: Craig D. Logsdon, Vijaya Ramachandran, Thiruvengadam Arumugam