Patents Assigned to Board of Regents, University of Texas System
  • Publication number: 20230352135
    Abstract: A method and system for generating a treatment plan are disclosed herein. A computing system receives a plurality of dose volume histograms for a plurality of patients and a plurality of volumetric dose distributions corresponding to the plurality of dose volume histograms. The computing system generates a volumetric dose prediction model using a neural network by learning, by the neural network, a relationship between a plurality of dose volume histograms for the plurality of patients and the corresponding plurality of volumetric dose distributions. The computing system receives a candidate dose volume histogram for a target patient. The computing system infers, via the volumetric dose prediction module, a volumetric dose prediction distribution matching the candidate dose volume histogram. The computing system generates a recommendation based on the inferred volumetric dose prediction distribution.
    Type: Application
    Filed: February 27, 2023
    Publication date: November 2, 2023
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Dan NGUYEN, Steve JIANG
  • Publication number: 20230346781
    Abstract: The present disclosure provides compounds, their pharmaceutical compositions, and methods of their use for treating mesenchymally-derived or mesenchymally-transformed cancers, such as breast cancers and sarcomas, and for treating diseases or disorders that are characterized by the expression of vimentin.
    Type: Application
    Filed: July 11, 2023
    Publication date: November 2, 2023
    Applicants: The Scripps Research Institute, Board of Regents, The University of Texas System
    Inventors: Luke L. LAIRSON, Michael J. BOLLONG, Peter G. SCHULTZ, Sendurai A. Mani
  • Publication number: 20230349914
    Abstract: Neoantigens play a key role in the recognition of tumor cells by T cells. However, only a small proportion of neoantigens truly elicit T cell responses, and fewer clues exist as to which neoantigens are recognized by which T cell receptors (TCRs). To help determine the TCRs that interact with particular neoantigens, prediction models that predict TCR-binding specificities of neoantigens presented by different classes of major histocompatibility complex (MHCs) were developed. To confirm the applicability of the model to clinical settings, the prediction models were comprehensively validated by a series of analyses. The validated prediction models used a flexible transfer learning approach and differential learning schema to achieve highly accurate prediction of TCR binding specificity only using TCR sequence data, antigen sequence data, and MHC alleles.
    Type: Application
    Filed: September 30, 2021
    Publication date: November 2, 2023
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Tianshi LU, Tao WANG
  • Publication number: 20230347173
    Abstract: A method of treating a tumor in a subject, the method comprises applying a tumor treating field to the tumor at a frequency between approximately 50 kHz and approximately 1,000 kHz; and delivering personalized ultra-fractionated adaptive radiotherapy (PULSAR) regimen.
    Type: Application
    Filed: March 31, 2023
    Publication date: November 2, 2023
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Michael D. STORY, Debabrata SAHA, Narasimha Kumar KARANAM
  • Publication number: 20230348599
    Abstract: The current disclosure provides for novel therapeutic methods by identifying glioblastoma patient populations that may be treated effectively by immunotherapies. Also provided are therapies that may be used in combination of immune checkpoint therapy (ICB) to increase the effectiveness of the therapy. Aspects of the disclosure relate to a method of treating glioblastoma in a subject comprising administering to the subject immune checkpoint blockade (ICB) therapy after the subject has been determined to have low expression of CD73 in a biological sample from the subject.
    Type: Application
    Filed: December 17, 2020
    Publication date: November 2, 2023
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Padmanee SHARMA, James ALLISON, Sreyashi BASU
  • Publication number: 20230348586
    Abstract: The present disclosure relates generally to therapeutic agents and related uses thereof, including, agents for reducing leptin in a patient or subject and methods of treatment thereof. The therapeutic agents can comprise (without limitation), an antibody or specific binding fragment thereof, a leptin antagonist, a leptin targeting antisense oligonucleotide, a leptin targeting small interfering RNA (siRNA), a leptin targeting short hairpin RNA (shRNA), and/or a gene editing composition directed to at least one target sequence of a leptin polynucleotide. The therapeutic agents can be used in various methods of treatment, including (without limitation), treating liver fibrosis, cancer, inducing or maintaining weight loss, reducing or preventing weight gain, and increasing insulin sensitivity, among others.
    Type: Application
    Filed: September 21, 2021
    Publication date: November 2, 2023
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Phillipp E. SCHERER, Shangang ZHAO, Zhiqiang AN, Ningyan ZHANG
  • Patent number: 11802272
    Abstract: Methods of, treatments using, and devices for restoring the regenerative capability for mesenchymal stem cells and isolating and expanding a small subpopulation of less defective mesenchymal stem cells from the bone marrow stromal cells of people with decreased quality and/or quantity of mesenchymal stem cells, such as elderly people.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: October 31, 2023
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Travis Block, Milos Marinkovic, Xiao-dong Chen
  • Patent number: 11801295
    Abstract: Immunogenic compositions comprising viral vectors and surfactants are provided. Methods for administration and preparation of such compositions are also provided.
    Type: Grant
    Filed: July 28, 2020
    Date of Patent: October 31, 2023
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Maria A. Croyle, Stephen Clay Schafer
  • Patent number: 11801218
    Abstract: Vaccine compositions that may be administered to a subject via the buccal and/or sublingual mucosa are provided. Methods for administration and preparation of such vaccine compositions are also provided.
    Type: Grant
    Filed: October 15, 2021
    Date of Patent: October 31, 2023
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Maria A. Croyle, Jin Huk Choi, Stephen Clay Schafer
  • Publication number: 20230342524
    Abstract: Systems and methods for simulating subterranean regions having fracture geometries. Non-intrusive embedded discrete fracture modeling formulations are applied to two-dimensional and three-dimensional unstructured grids, with mixed elements, using an element-based finite-volume method in conjunction with commercial simulators to model subsurface characteristics in regions having complex hydraulic fractures, complex natural fractures, or a combination of both.
    Type: Application
    Filed: May 23, 2023
    Publication date: October 26, 2023
    Applicants: Sim Tech LLC, Board of Regents, The University of Texas System
    Inventors: Kamy Sepehrnoori, Yifei Xu, Wei Yu, Francisco Marcondes, Jijun Miao
  • Publication number: 20230338485
    Abstract: Embodiments of the present disclosure pertain to methods of treating or preventing a cancer in a subject by administering to the subject an immunogenic peptide and/or a nucleotide sequence that expresses the immunogenic peptide. Thereafter, the administered or expressed immunogenic peptide elicits an immune response against cells associated with the cancer. The immunogenic peptides contain a neoantigenic region and are expressed by chimeric nucleotide sequences derived from cells associated with the cancer. The chimeric nucleotide sequences have a higher prevalence in cancer cells when compared to non-cancer cells. Further embodiments pertain to compositions that include the immunogenic peptides of the present disclosure and/or a nucleotide sequences that express them.
    Type: Application
    Filed: September 23, 2021
    Publication date: October 26, 2023
    Applicants: UNIVERSITY OF HOUSTON SYSTEM, BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Preethi Gunaratne, Brandon Mistretta, Sakuni Rankothgedera, Micah Castillo, Isabelle Bedrosian
  • Patent number: 11795457
    Abstract: Described are compounds and methods useful for the treatment and investigation of Friedreich's Ataxia.
    Type: Grant
    Filed: September 27, 2021
    Date of Patent: October 24, 2023
    Assignee: The Board of Regents of The University of Texas System
    Inventors: David Corey, Liande Li
  • Patent number: 11794040
    Abstract: Apparatuses and methods for generating therapeutic shock waves. Some embodiments comprise: an acoustic-wave generator configured to emit acoustic waves having at least one frequency between 1 MHz and 1000 MHz; a shock wave housing coupled to the acoustic-wave generator; and a shock wave medium disposed in the shock wave housing; where the apparatus is configured such that if the acoustic-wave generator emits acoustic waves then at least some portion of the acoustic waves will travel through the shock wave medium and form one or more shock waves.
    Type: Grant
    Filed: January 19, 2011
    Date of Patent: October 24, 2023
    Assignee: The Board of Regents of the University of Texas System
    Inventor: Christopher C. Capelli
  • Patent number: 11795512
    Abstract: The present disclosure provides methods and compositions for the detection of bladder in a subject using four locus-specific probes to 6p22, 8q22, 11q13, and 20p11.2.
    Type: Grant
    Filed: January 30, 2019
    Date of Patent: October 24, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Bogdan Czerniak, Keith Baggerly, Jolanta Bondaruk, Tadeusz Majewski, Colin Dinney, Shizhen Zhang, Yan Wang
  • Patent number: 11794175
    Abstract: A metal-free porphyrin based crystalline 2D organic polymer obtained from the condensation of terephthaloyl chloride and 5,10,15,20-tetrakis(4-aminophenyl porphyrin, namely H2TAPP), which is an effective bifunctional electrocatalyst for the oxygen evolution reaction (OER) in basic conditions and the hydrogen evolution reaction (HER) in neutral solutions. The electrochemical response of this material is explored under oxidation and reduction conditions in order to study its catalytic activity, charge transfer and stability.
    Type: Grant
    Filed: February 23, 2021
    Date of Patent: October 24, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Dino Villagran, Yulu Ge
  • Patent number: 11793439
    Abstract: Epidermal electronics are non-invasive and non-obstructive skin mounted sensors with mechanical properties matching human epidermis. Their manufacturing process includes photolithography and dry and wet etching within cleanroom facilities. The high cost of manpower, materials, photo masks, and facilities greatly hinders the commercialization potential of disposable epidermal electronics. In contrast, an embodiment of the invention includes a low cost, high throughput, bench top “cut-and-paste” method to complete the freeform manufacture of epidermal sensor system (ESS) in minutes. This versatile method works for many types of thin metal and polymeric sheets and is compatible with many tattoo adhesives or medical tapes. The resultant ESS is highly multimaterial and multifunctional and may measure ECG, EMG, skin temperature, skin hydration, as well as respiratory rate.
    Type: Grant
    Filed: April 26, 2022
    Date of Patent: October 24, 2023
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Nanshu Lu, Shixuan Yang, Pulin Wang
  • Patent number: 11787839
    Abstract: The present disclosure provides ?2?-1 C-terminal domain mimetics for the treatment of pain, epilepsy or other disorders in a subject. Further provided is an ?2?-1 C-terminal domain peptide which blocks binding of ?2?-1 to the glutamate receptors NMDAR and AMPAR.
    Type: Grant
    Filed: August 14, 2018
    Date of Patent: October 17, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventor: Hui-lin Pan
  • Patent number: 11786170
    Abstract: Nanomaterial epidermal sensors can be adhered to the skin and worn comfortably and inconspicuously for days to allow for repeated biometric sensing. The nanomaterial epidermal sensors may be comprised of a monolayer of graphene coating a flexible polymer substrate. Various nanomaterial epidermal sensors may be quickly fabricated using a cost-efficient “cut-and-paste” method on transfer paper and can be adhered directly to skin without tape or adhesive, much like a temporary-tattoo. The nanomaterial epidermal sensors may be optically transparent and may be used to measure an electrocardiogram (ECG), an electroencephalogram (EEG) or an electromyogram (EMG) with a signal-to-noise ratio that is comparable to conventional electrodes. In addition, the nanomaterial epidermal sensors may be used to measure other parameters, such as skin temperature or skin hydration.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: October 17, 2023
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Nanshu Lu, Deji Akinwande, Shideh Kabiri Ameri Abootorabi
  • Patent number: 11791867
    Abstract: A disclosed transmitter for wireless communication includes multiple transmitting antennas, a symbol mapper for mapping an input block including multiple binary bits and representing information to be transmitted to a symbol representing an ordered plurality of complex numbers, a space-time encoder for applying an encoding operator to the symbol to produce a vectorized space-time codeword defining electrical signals to be transmitted by the transmitter, the encoding operator being dependent on a set of predefined stabilizer generators, and circuitry to collectively transmit, by the antennas to multiple receiving antennas of a receiver over a wireless transmission channel, the electrical signals defined by the vectorized space-time codeword. The receiver includes a space-time decoder for recovering the symbol from the electrical signals transmitted by the transmitter using a decoding operation that is based on maximum likelihood inference, and a symbol de-mapper for recovering the input block from the symbol.
    Type: Grant
    Filed: December 29, 2021
    Date of Patent: October 17, 2023
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: S. Andrew Lanham, Travis Cuvelier, Brian R. La Cour, Robert Heath
  • Patent number: 11786464
    Abstract: Described herein are therapeutic pH responsive compositions comprising a block copolymer and a therapeutic agent useful for the treatment of cancer.
    Type: Grant
    Filed: April 26, 2021
    Date of Patent: October 17, 2023
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Jinming Gao, Tongyi Huang, Qiang Feng, Baran Sumer