Patents Assigned to Board of Regents, University of Texas System
  • Material and device properties modification by electrochemical charge injection in the absence of contacting electrolyte for either local spatial or final states
    Publication number: 20100304215
    Abstract: In some embodiments, the present invention is directed to processes for the combination of injecting charge in a material electrochemically via non-faradaic (double-layer) charging, and retaining this charge and associated desirable properties changes when the electrolyte is removed. The present invention is also directed to compositions and applications using material property changes that are induced electrochemically by double-layer charging and retained during subsequent electrolyte removal. In some embodiments, the present invention provides reversible processes for electrochemically injecting charge into material that is not in direct contact with an electrolyte. Additionally, in some embodiments, the present invention is directed to devices and other material applications that use properties changes resulting from reversible electrochemical charge injection in the absence of an electrolyte.
    Type: Application
    Filed: October 13, 2006
    Publication date: December 2, 2010
    Applicant: Board of Regents of University of Texas System
    Inventors: Dong-Seok Suh, Ray Henry Baughman, Anvar Abdulahadovic Zakhidov
  • Material and device properties modification by electrochemical charge injection in the absence of contacting electrolyte for either local spatial or final states
    Publication number: 20100301734
    Abstract: In some embodiments, the present invention is directed to processes for the combination of injecting charge in a material electrochemically via non-faradaic (double-layer) charging, and retaining this charge and associated desirable properties changes when the electrolyte is removed. The present invention is also directed to compositions and applications using material property changes that are induced electrochemically by double-layer charging and retained during subsequent electrolyte removal. In some embodiments, the present invention provides reversible processes for electrochemically injecting charge into material that is not in direct contact with an electrolyte. Additionally, in some embodiments, the present invention is directed to devices and other material applications that use properties changes resulting from reversible electrochemical charge injection in the absence of an electrolyte.
    Type: Application
    Filed: October 13, 2006
    Publication date: December 2, 2010
    Applicant: Board of Regents of University of Texas System
    Inventors: Dong-Seok Suh, Ray Henry Baughman, Anvar Abdulahadovic Zakhidov
  • BIOMARKERS FOR THE DETECTION OF EARLY STAGE OVARIAN CANCER
    Publication number: 20100304993
    Abstract: The present invention provides methods and compositions for detecting early stage ovarian cancer in a patient. Also, methods for evaluating the ovarian cancer state of a patient are described herein. These methods involve the detection, analysis, and classification of biomarkers in biological samples.
    Type: Application
    Filed: April 29, 2010
    Publication date: December 2, 2010
    Applicants: VERMILLLION, INC., Board of Regents, The University of Texas System
    Inventors: Eric T. Fung, Charlotte Clarke, Robert C. Bast, JR., Kevin R. Coombes
  • Controlled Release Hydrogel Films
    Publication number: 20100303877
    Abstract: The present invention provides hydrogels and methods of making hydrogels with precisely controlled levels of chemical compositions by mixing one or more monomers in a plasma reactor; polymerizing the one or more monomers into a polymer; crosslinking the polymer to form a hydrogel; immersing the hydrogel in a first solution; and adsorbing one or more solute species from the solution, wherein the one or more solute species are released at controlled rates.
    Type: Application
    Filed: June 1, 2010
    Publication date: December 2, 2010
    Applicant: Board of Regents, The University of Texas System
    Inventors: Richard B. Timmons, Wen Chyan, Dhiman Bhattacharyya
  • Rotating catheter probe using a light-drive apparatus
    Patent number: 7844321
    Abstract: The invention is a rotating tip catheter-imaging probe where electromagnetic energy is delivered to the distal end of a catheter and converted to mechanical energy using a light drive apparatus. The mechanical energy is then used to rotate a mirror that redirects light in fixed pattern on a sample. The rotating element of the light drive apparatus contains vanes, which rotate about an axis and positioned with bearings to minimize friction. A chamber encompasses the rotating element and is set to a vacuum pressure. The rotational speed of the catheter tip can be controlled by varying the optical power delivered to the vanes, the vacuum pressure in the chamber, or by a braking mechanism applied to the rotating element. The vanes may be shaped in a particular geometry to increase forces on the vanes from thermally driven gas flow.
    Type: Grant
    Filed: December 6, 2006
    Date of Patent: November 30, 2010
    Assignee: Board of Regents, the University of Texas System
    Inventors: Thomas E. Milner, Nathaniel J. Kemp
  • ENCAPSULATED PARTICLES FOR AMORPHOUS STABILITY ENHANCEMENT
    Publication number: 20100297248
    Abstract: The present invention provides compositions and methods of making and encapsulating one or more active agents in a chemical vapor deposition layer to enhance the stability.
    Type: Application
    Filed: May 21, 2010
    Publication date: November 25, 2010
    Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, AEONCLAD COATINGS, LLC
    Inventors: Richard B. Timmons, Ceren Susut, Donald E. Owens, III, J. Brian Windsor, Rachel Kennedy Khorzad
  • ENCAPSULATED PARTICLES FOR ENTERIC RELEASE
    Publication number: 20100297251
    Abstract: The present invention provides a system for delivery of an enteric coated active agent generally resistant to disintegration in an neutral environment having one or more active agents encapsulated by a polymer coating formed by chemical vapor deposition of one or more monomers on the one or more active agents to form a chemical vapor deposition polymer coating that controls the release of the one or more active agents in the gastrointestinal tract.
    Type: Application
    Filed: May 21, 2010
    Publication date: November 25, 2010
    Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, AEONCLAD COATINGS, LLC
    Inventors: Richard B. Timmons, Ceren Susut, Donald E. Owens, III, J. Brian Windsor, Rachel Kennedy Khorzad
  • USE OF NOVEL NEUROPROTECTIVE 3-SUBSTITUTED INDOLONE COMPOSITIONS
    Publication number: 20100298376
    Abstract: The present invention provides compositions and methods of synthesizing optionally substituted 3-substituted indolin-2-ones and methods to employ the resultant compounds to protect against neurodegeneration including diseases such as Alzheimer's disease, Parkinson's disease, or Huntington's disease, and conditions such as ischemic stroke.
    Type: Application
    Filed: May 13, 2010
    Publication date: November 25, 2010
    Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, SOUTHERN METHODIST UNIVERSITY
    Inventors: Santosh R. D'Mello, Edward A. Biehl
  • METHODS AND COMPOSITIONS TO REDUCE SCATTERING OF LIGHT DURING THERAPEUTIC AND DIAGNOSTIC IMAGING PROCEDURES
    Publication number: 20100298716
    Abstract: Disclosed are improved methods and compositions for use in light-based in vivo imaging and treatment. The techniques described involve the use of low-scattering, oxygen-carrying blood substitutes in imaging and treatment methods, including OCT imaging. The invention has particular advantages in imaging within the cardiovascular system and highly vascularized or oxygen-dependent tissues.
    Type: Application
    Filed: May 14, 2010
    Publication date: November 25, 2010
    Applicant: Board of Regents, the University of Texas System
    Inventors: Joseph W. Villard, Marc D. Feldman, Thomas E. Milner, JeeHyun Kim, Gregory L. Freeman
  • Compositions and methods for treating, preventing and/or ameliorating cancers, the onset of cancers or the symptoms of cancers
    Patent number: 7838511
    Abstract: Compositions and methods are disclosed for treating, preventing and/or ameliorating the symptoms of cancers such as breast cancer, colon cancer, ovarian cancer, lung cancer, leukemia, skin cancer, prostate cancer, throat cancer, esophageal cancer etc., where the composition includes an associated complex of a nonsteroidal, anti-inflammatory drug (NSAID) and a phospholipid and the method includes administering before or after cancer identification an anti-cancer amount of the compositions.
    Type: Grant
    Filed: August 2, 2004
    Date of Patent: November 23, 2010
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Lenard M. Lichtenberger, Elizabeth J. Dial
  • Linear induction machine control scheme, systems, and methods
    Patent number: 7839101
    Abstract: A method and system for a control scheme for linear induction machines. The control scheme includes a maximum energy conversion ratio and a maximum acceleration and deceleration for linear induction machines.
    Type: Grant
    Filed: May 2, 2008
    Date of Patent: November 23, 2010
    Assignee: Board of Regents, The University of Texas System
    Inventors: Haidong Yu, Babak Fahimi
  • Ethers of 3-hydroxyphenylacetic acid as selective gamma-hydroxybutyric acid receptor ligands
    Patent number: 7838556
    Abstract: The present invention generally relates to pharmaceutical compositions comprising ethers of 3-hydroxyphenylacetic acid. The present invention also relates to therapeutic uses of the ethers of 3-hydroxyphenylacetic acid. The ethers of 3-hydroxyphenylacetic acid have the chemical structural of formula (I): where R is an aromatic or arylalkyl substituent.
    Type: Grant
    Filed: February 16, 2007
    Date of Patent: November 23, 2010
    Assignees: University of Maryland, Baltimore, Board of Regents, The University of Texas System
    Inventors: Andrew Coop, Maharaj K. Ticku, Charles P. France
  • Palmerolides: methods of preparation and derivatives thereof
    Patent number: 7838691
    Abstract: Organic compounds having Formulas I and II are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier can be prepared. Methods of preparing the compounds includes deprotecting protected precursor compounds. Methods of treating cancer or inhibiting ATPase include administering the organic compounds to a subject in need thereof.
    Type: Grant
    Filed: April 4, 2008
    Date of Patent: November 23, 2010
    Assignee: Board of Regents, of the University of Texas System
    Inventors: Jef K. De Brabander, Xin Jiang, Bo Liu
  • USE OF FLUOROCARBON SURFACTANTS TO IMPROVE THE PRODUCTIVITY OF GAS AND GAS CONDENSATE WELLS
    Publication number: 20100292110
    Abstract: The present invention includes composition having a nonionic, fluorinated polymeric surfactant, water and solvent. Embodiments of compositions according to the present invention are useful, for example, for recovering hydrocarbons from subterranean clastic formations.
    Type: Application
    Filed: June 30, 2010
    Publication date: November 18, 2010
    Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: Gary A. Pope, Mukul M. Sharma, Viren Kumar, Jimmie R. Baran
  • NUCLEIC ACID MOLECULES AND PROTEINS FOR THE IDENTIFICATION, ASSESSMENT, PREVENTION, AND THERAPY OF OVARIAN CANCER
    Publication number: 20100291068
    Abstract: The invention relates to newly discovered nucleic acid molecules and proteins associated with ovarian cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human ovarian cancers are provided.
    Type: Application
    Filed: March 8, 2010
    Publication date: November 18, 2010
    Applicants: MILLENNIUM PHARMACEUTICALS, INC., Board of Regents, The University of Texas System
    Inventors: Wilson O. Endege, Donna Ford, Manjula Gannavarapu, Karen Glatt, Sebastian Hoersch, Shubhangi Kamatkar, John E. Monahan, Robert Schlegel, Yong Yao Xu, Xumei Zhao, Robert C. Bast, JR., Gordon B. Mills, Karen Lu
  • TRYPHOSTIN-ANALOGS FOR THE TREATMENT OF CELL PROLIFERATIVE DISEASES
    Publication number: 20100292229
    Abstract: The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. In general aspects, compounds of the present invention are tyrphostin-like in structure. Compounds of the present invention, in certain embodiments, display significant potency by causing, for example, inhibition of Stat3 activation, reduction in c-myc protein levels and/or induction of apoptosis in tumor cells. In general aspects, compounds of the present invention induce one or more of these activities at nanomolar concentrations and typically function through a unique mechanism involving the induction of stress granules that bind specific signaling molecules and prevent them from participating in signal transduction and oncogenesis.
    Type: Application
    Filed: July 2, 2007
    Publication date: November 18, 2010
    Applicant: The Board of Regents of the University of Texas System
    Inventors: Nicholas J Donato, David Maxwell, Moshe Talpaz, William Bornmann, Zhenghong PENG, Ashutosh Pal, Dongmei Han, Shimei Wang, Geoffrey Bartholomeusz, Vaibhav Kapuria
  • SCREENING SYSTEM FOR DETECTING INHIBITORS OF HIV INTEGRASE-LEDGF/p-75 INTERACTION
    Publication number: 20100291606
    Abstract: The development and validation of a cell-based, homogeneous high throughput screening (HTS) assay for small compounds inhibiting the HIV integrase-LEDGF/p75 interaction is described herein. The HTS strategy has the potential to identify small-molecules interfering with the interaction of HIV integrase-LEDGF/p75. These small molecules represent starting scaffolds for therapeutic drug development.
    Type: Application
    Filed: May 13, 2010
    Publication date: November 18, 2010
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Manuel Llano, Elisa Morales
  • RETICULATED MESH ARRAYS AND DISSIMILAR ARRAY MONOLITHS BY ADDITIVE LAYERED MANUFACTURING USING ELECTRON AND LASER BEAM MELTING
    Publication number: 20100291401
    Abstract: Compositions and methods for making a three dimensional structure comprising: designing a three-dimensional structure; melting the three-dimensional structure from two or more layers of a metal powder with a high energy electron or laser beam is described herein. The position where the metal is melted into the structure is formed along a layer of metal powder, wherein the location and intensity of the beam that strikes the metal layer is based on the three-dimensional structure and is controlled and directed by a processor. The instant invention comprises a novel dry state sonication step for removing metal powder that is not melted from the three dimensional structure.
    Type: Application
    Filed: May 14, 2010
    Publication date: November 18, 2010
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Frank Medina, Lawrence Murr, Ryan Wicker, Sara Gaytan
  • SYSTEMS AND METHODS INCLUDING SELF-CONTAINED CARTRIDGES WITH DETECTION SYSTEMS AND FLUID DELIVERY SYSTEMS
    Publication number: 20100291588
    Abstract: Methods, systems, and apparatus for detecting the presence of analytes are described. A fluid or gas sample may pass through a microsieve-based detection system and/or a particle-based detection system of a cartridge. Detection and analysis techniques may be applied to determine the identity and quantity of the captured analytes.
    Type: Application
    Filed: June 23, 2006
    Publication date: November 18, 2010
    Applicant: The Board of Regents of the University of Texas System
    Inventors: John T. McDevitt, Karri Ballard, Nicolaos J. Christodoulides, Pierre N. Floriano, Glennon W. Simmons
  • Plasmonic laser nanoablation methods
    Patent number: 7834331
    Abstract: A novel femtosecond laser nano-ablation technique called Plasmonic Laser Nano-Ablation (PLN). The technique takes advantage of surface-enhanced plasmonic scattering of ultrashort laser pulses by nanoparticles to vaporize sub-cellular structures in attoliter volumes. The use of nanoparticles may overcome problems associated with current FLMS techniques and does not rely on heating for nanodisruption. In PLN, the particle acts as a “nano-lens,” restricting laser light to the near-field of the particle, and only photodisrupting structures that are nanometers away. This eliminates the need for a tightly focused beam, while still achieving nanoscale ablation resolution. Moreover, the enhanced scattering around the particles reduces the amount of required laser fluence.
    Type: Grant
    Filed: August 1, 2008
    Date of Patent: November 16, 2010
    Assignee: Board of Regents, The University of Texas System
    Inventors: Adela Ben-Yakar, Daniel Eversole, Xun Guo