Patents Assigned to Board of Regents, University of Texas Systems
  • Patent number: 10984964
    Abstract: Disclosed herein are stretchable strain sensors that include a graphite network embedded within an elastomeric material. The sensors are wearable and can be used to detect mechanical movements in three dimensions in a wide variety of contexts.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: April 20, 2021
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Donglei Fan, Weigu Li, Jianhe Guo
  • Patent number: 10980841
    Abstract: Embodiments of the invention stimulate three levels of beta cell physiology: (i) glucose metabolism, (ii) membrane receptor function, and (iii) transcriptional factors that result in the in vivo formation of beta cells in the pancreas for the purpose of treating diabetes.
    Type: Grant
    Filed: April 25, 2019
    Date of Patent: April 20, 2021
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Bruno Doiron, Ralph A Defronzo
  • Patent number: 10982068
    Abstract: The present invention includes a hydrogel and a method of making a porous hydrogel by preparing an aqueous mixture of an uncrosslinked polymer and a crystallizable molecule; casting the mixture into a vessel; allowing the cast mixture to dry to form an amorphous hydrogel film; seeding the cast mixture with a seed crystal of the crystallizable molecule; growing the crystallizable molecule into a crystal structure within the uncrosslinked polymer; crosslinking the polymer around the crystal structure under conditions in which the crystal structure within the crosslinked polymer is maintained; and dissolving the crystals within the crosslinked polymer to form the porous hydrogel.
    Type: Grant
    Filed: October 9, 2019
    Date of Patent: April 20, 2021
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Scott Zawko, Christine Schmidt
  • Patent number: 10980847
    Abstract: The present invention includes composition, methods and kits for detecting and treating brain injury associated fatigue or altered cognition (BIAFAC) in a human patient comprising: identifying a human patient in need of treatment for brain injury associated fatigue or altered cognition associated with an altered intestinal flora; and providing the human patient with a composition comprising at least one of: a Prevotella spp or a Bacteroidies spp bacteria, or one or more agents that increase the amount of the Prevotella spp or the Bacteroidies spp bacteria in an intestinal flora of the human patient to reduce or eliminate the brain injury associated fatigue or altered cognition.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: April 20, 2021
    Assignee: Board of Regents, The University of Texas System
    Inventors: Randall J. Urban, Melinda Sheffield-Moore, Richard Pyles, Brent Masel
  • Patent number: 10983247
    Abstract: The present disclosure describes various systems and methods for measuring environmental parameters. In one embodiment, such as system comprises a pole that is equipped with various instruments (sensors) at various heights along the length of the pole. With such an instrumented pole, a local vertical profile of parameters that relate to wind conditions and air quality can be obtained. These parameters can include one or more of wind speed and direction, air turbulence, air temperature and humidity, concentrations of pollutant gases within the air, and concentrations of pollutant particles within the air. In some embodiments, the system can further measure other parameters that are relevant to the migration of the air and, therefore, the pollutants it contains.
    Type: Grant
    Filed: February 11, 2020
    Date of Patent: April 20, 2021
    Assignee: Board of Regents, The University of Texas System
    Inventors: Kiran Bhaganagar, Prasanna R V Kolar, Sudheer Reddy Bhimireddy, Jordan Nielson
  • Patent number: 10981896
    Abstract: The present disclosure relates to indolinone compounds, compositions, and methods for the inhibition of maternal embryonic leucine zipper kinase (MELK). The present disclosure further relates to indolinone compounds, compositions, and methods for the treatment or prevention of a cancer (for example, triple negative breast cancer).
    Type: Grant
    Filed: March 2, 2018
    Date of Patent: April 20, 2021
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Kevin N. Dalby, Ramakrishna Edupuganti, Juliana Taliaferro, Ju Hyeon Lee
  • Patent number: 10985700
    Abstract: Disclosed are various embodiments of a terahertz wave modulator. The wave modulator can include one or more layers of piezoelectric/ferroelectric single crystal or polycrystalline material. The crystalline material can be configured to resonate when a low-energy external excitation is applied. An incident terahertz waveform can be dynamically controlled when the incident terahertz waveform interacts with the at least one layer of piezoelectric crystalline material while the at least one layer of piezoelectric crystalline material is resonating. The dynamic control of the incident terahertz waveform can be with respect to at least one of a phase shift and an amplitude modulation of the waveform.
    Type: Grant
    Filed: March 17, 2020
    Date of Patent: April 20, 2021
    Assignee: Board of Regents, The University of Texas System
    Inventors: Moumita Dutta, Ruyan Guo, Amar Bhalla, Soutik Betal
  • Publication number: 20210108181
    Abstract: Certain embodiments are directed to an improved RVF vaccine for human use, and method for producing the same.
    Type: Application
    Filed: October 9, 2020
    Publication date: April 15, 2021
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventor: Tetsuro IKEGAMI
  • Publication number: 20210107914
    Abstract: Methods and compositions for agonizing a type-2 orexin receptor (OX2R) in a cell determined to be in need thereof, including the general method of (a) administering to a subject a cyclic guanidinyl OX2R agonist and (b) detecting a resultant enhanced wakefulness or increased resistance to diet-induced accumulation of body fat, or abbreviated recovery from general anesthesia or jet lag.
    Type: Application
    Filed: September 27, 2020
    Publication date: April 15, 2021
    Applicant: Board of Regents, The University of Texas System
    Inventors: Jef De Brabander, Daniel Rosenbaum, Qiren Liang, Wentian Wang
  • Patent number: 10975059
    Abstract: The invention relates generally to novel small molecule BRD4 modulators for HIV, the preparation thereof as well as the use thereof.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: April 13, 2021
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Haitao Hu, Jia Zhou, Zhiqing Liu
  • Patent number: 10975142
    Abstract: Aspects of the present invention relate to methods and reagents for increasing chemosensitivity to platinum-based chemotherapy. In one aspect, a method of increasing chemosensitivity to platinum-based chemotherapy is provided, comprising administering to a patient in need thereof an effective amount of an endotrophin-neutralizing agent. The agent can be a monoclonal antibody, or fragment thereof, capable of binding to the C5 domain of the alpha3 chain of collagen VI. In some embodiments, the method can further include administering an effective amount of thiazolidinedione to said patient.
    Type: Grant
    Filed: January 9, 2019
    Date of Patent: April 13, 2021
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Philipp Erich Scherer, Jiyoung Park, Zhiqiang An
  • Patent number: 10974499
    Abstract: A three-dimensional electronic, biological, chemical, thermal management, and/or electromechanical apparatus can be configured by depositing one or more layers of a three-dimensional structure on a substrate. Such a three-dimensional structure can include one or more internal cavities using an additive manufacturing system enhanced with a range of secondary embedding processes. The three-dimensional structure can be further configured with structural integrated metal objects spanning the internal cavities (possibly filled with air or even evacuated) of the three-dimensional structure for enhanced electromagnetic properties.
    Type: Grant
    Filed: October 7, 2019
    Date of Patent: April 13, 2021
    Assignee: Board of Regents, The University of Texas System
    Inventors: Eric MacDonald, Ryan Wicker, David Espalin
  • Patent number: 10979471
    Abstract: The present disclosure describes various embodiments of surveillance systems and methods. In one such embodiment, an exemplary surveillance system includes at least one video camera configured to capture video data of a surveilled area; and a computing device that stores a surveillance program. An exemplary surveillance program includes computer-executable instructions configured to: analyze the video data captured by the at least one video camera; identify objects that enter the surveilled area and log a time at which the objects entered the surveilled area; determine an object type for each object; track the identified objects to determine a period of time the objects have been present within the surveilled area; and generate and transmit an alert for each identified object that has been present within the surveilled area for a period of time that exceeds a predetermined time threshold.
    Type: Grant
    Filed: September 20, 2019
    Date of Patent: April 13, 2021
    Assignee: Board of Regents, The University of Texas System
    Inventors: Berat Alper Erol, Abhijit Majumdar, Patrick Benavidez, Divya Bhaskaran, Mohammad Jamshidi, Benjamin Factor, Arman Rezakhani
  • Patent number: 10974443
    Abstract: A method, system, and apparatus for fabricating a three-dimensional circuit is provided. In an embodiment, a method for fabricating a three-dimensional circuit by an additive manufacturing process includes determining a shape, location, and spatial orientation of a number of components, a number of dielectrics, and a number of metal interconnects for the three dimensional circuit. The method also includes obtaining fused filament fabrication (FFF) specific actions for a number of dielectric materials and the metal interconnects. The method also includes separating tool paths of the dielectric material and the metal interconnects into individual tool paths for each of the dielectric materials and the metal interconnects. The method also includes removing specific actions for one of the individual toolpaths from an FFF specific action. The method also includes rewriting the one of the individual toolpaths into micro-dispensing actions to control a tool for micro-dispensing ink.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: April 13, 2021
    Assignee: Board of Regents, The University of Texas System
    Inventors: Raymond C. Rumpf, Cesar Luis Valle, Gilbert Carranza, Ubaldo Robles
  • Patent number: 10974004
    Abstract: Techniques for automated titration of CPAP device for a subject include receiving multiple ultrasound images representing a cross section of an airway in a neck of the subject at corresponding different times. Multiple different positive pressure values imposed by a device on the airway of the subject are also received at each of the corresponding times. For each of the ultrasound images, a mask of pixels associated with an air-tissue interface is automatically formed, and a value of a statistic of pixels within the mask is automatically determined. A titration pressure for a continuous positive airway pressure (CPAP) device is automatically determined based on the positive pressures and the value of the statistic for each of the ultrasound images. Output data that indicates the titration pressure for the CPAP device is presented on a display device, such as by operating the CPAP device itself at the titration pressure.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: April 13, 2021
    Assignees: University Of Maryland, Baltimore, Board of Regents, The University of Texas System
    Inventors: Jeffrey S. Wolf, Amal Isaiah
  • Patent number: 10973764
    Abstract: Methods for the treatment of stroke, such as stroke of undetermined origin, by administration of xenon (Xe)-loaded liposome compositions are provided. In some aspects, Xe is encapsulated in echogenic liposomes and release of Xe can be enhanced by application of ultrasound stimulation. Compositions for use in treating stroke, such as liposomes loaded with Xe or Xe in combination with H2 or H2S, are also provided.
    Type: Grant
    Filed: June 26, 2019
    Date of Patent: April 13, 2021
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Shao-Ling Huang, Melvin E. Klegerman, Yong-Jian Geng, Hyunggun Kim, David D. Mcpherson
  • Publication number: 20210102961
    Abstract: Methods and kits are provided for amplifying and detecting misfolded proteins from samples, for example, from patients having Alzheimer's Disease, Parkinson's Disease, and the like. For example, a method for determining a presence of soluble, misfolded protein in a sample may include contacting the sample with a monomeric, folded protein to form an incubation mixture; conducting an incubation cycle two or more times effective to form an amplified portion of misfolded protein; incubating the incubation mixture effective to cause misfolding and/or aggregation of at least a portion of the monomeric, folded protein; physically disrupting the incubation mixture effective to break up at least a portion of any protein aggregate present; and determining the presence of the soluble, misfolded protein in the sample by detecting at least a portion of the soluble, misfolded protein. The monomeric, folded protein and the soluble, misfolded protein may exclude prion protein (PrP) and isoforms thereof.
    Type: Application
    Filed: December 15, 2020
    Publication date: April 8, 2021
    Applicants: Board of Regents of the University of Texas System, Amprion, Inc.
    Inventors: Claudio Soto-Jara, Russell M. Lebovitz, Benedikt K. Vollrath, Mohammad Shahnawaz
  • Patent number: 10967065
    Abstract: In some aspects, pegylated aminoglycoside compounds are provided. In some embodiments, m-PEG-tobramycin compounds may be used to treat a biofilm infection or reduce or treat established biofilms.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: April 6, 2021
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Hugh Smyth, Ju Du
  • Patent number: 10966950
    Abstract: The present specification provides combinations of active agents for the improved treatment of Her2+ cancers and associated methods of treatments. The combinations comprise and RXR agonist and a Her2-targeted therapeutic agent and may optionally further comprise thyroid hormone.
    Type: Grant
    Filed: June 10, 2020
    Date of Patent: April 6, 2021
    Assignees: Io Therapeutics, Inc., Board of Regents, The University of Texas System
    Inventors: Martin E. Sanders, Powel H. Brown
  • Patent number: 10968105
    Abstract: Methods of pyrolytically producing carbons comprising graphene sheets at temperatures below 800° C. are disclosed. The graphene sheets, which are not substantially stacked, are formed by templating on hexagonal metal oxides, for example. Extensive stacking of the graphene sheets, which would lead to formation of graphite, is avoided at the low temperatures employed. Also provided are methods of producing heavily nitrogen doped graphene comprising carbons. Methods of using graphene and heavily nitrogen doped graphene are also disclosed.
    Type: Grant
    Filed: March 28, 2017
    Date of Patent: April 6, 2021
    Assignee: Board of Regents, The University of Texas System
    Inventors: Adam Heller, Joo-Woon Lee, David Eisenberg, Keith A. Friedman, Sheryl Coffman