Abstract: An apparatus and method for measuring three-dimensional radiation dose distributions with high spatial and temporal resolution using a large-volume scintillator. The scintillator converts the radiation dose distribution into a visible light distribution. The visible light is transported to one or more photo-detectors, which measure the light intensity. The light signals are processed to correct for optical artifacts, and the three-dimensional light distribution is reconstructed. The reconstructed light distribution is post-processed to convert light amplitudes to measured radiation doses. The high temporal resolution of the detector makes it possible to observe the evolution of a dynamic dose distribution as it changes over time. Integral dose distributions can be measured by summing the dose over time.

Abstract: Certain embodiments are directed to methods of treating a pathophysiological state or symptoms thereof resulting from aldose reductase-mediated signaling in a cytotoxic pathway using an aldose reductase specific inhibitor.

Abstract: In general, various embodiments of the present invention comprise an external fixation device, an internal fixation device, and a lower extremity stabilizer. The external fixation device is connected to the lower extremity stabilizer and the external fixation device is adjustably connected to the internal fixation device. The internal fixation device is capable of being attached to at least one bone in a patient's foot, ankle, and/or lower extremity.

Abstract: Provided are monoclonal antibodies that detect CD 19 CAR-modified immune cells and CAR-modified immune cells irrespective of the tumor associated antigen they target. Methods of using these functional monoclonal antibodies include, but are not limited to, detection, quantification, activation, and selective propagation of CAR-modified immune cells.

Abstract: In certain aspects the methods comprise administering an inhibitor of hydrogen sulfide biosynthesis, a cystathionine-?-synthase (CBS) inhibitor, or a hydrogen sulfide neutralizing agent to a patient having a cancer associated with elevated production of hydrogen sulfide.

Abstract: The invention provides compositions for inhibiting a redox-sensitive GTPase protein, including a Rho or Rab family GTPase, comprising an effective amount of a redox-sensitive purine compound and an effective amount of a redox agent. The invention further provides methods of inhibiting a redox-sensitive GTPase protein, including a Rho or Rab family GTPase, by administering compositions of the invention. Methods of screening for compounds that inhibit a redox-sensitive GTPase protein, including compounds that target and inhibit Rho or Rab family GTPases, are further provided.

Abstract: A method includes receiving toolface information corresponding to a location of the bottom hole assembly (BHA) with respect to a target drilling path and drift information. The surface steerable system calculates a first toolface vector from a first location of the BHA to the target drilling path to create a convergence path to the target drilling path and calculates an adjustment of the first toolface vector to a second toolface vector to account for system drift defined by the drift information such that the BHA will converge with the target drilling path by drilling in accordance with the second toolface vector. The surface steerable system modifies at least one drilling parameter to alter a drilling direction of the BHA based on the calculated second toolface vector and transmits the at least one drilling parameter to the drilling rig to target the BHA in accordance with the second toolface vector.

Abstract: Disclosed herein are mixed metal-organic frameworks, Zn3(BDC)3[Cu(SalPycy)] and Zn3(CDC)3[Cu(SalPycy)], wherein BDC is 1,4-benzenedicarboxylate, CDC is 1,4-cyclohexanedicarboxylate, and SalPyCy is a ligand of the formula: These are useful for applications such as selective gas storage, selective molecular separations, and selective detection of molecules, including enantioselective applications thereof.

Abstract: An apparatus for measuring complex electrical admittance and/or complex electrical impedance in animal or human patients includes a first electrode and at least a second electrode which are adapted to be disposed in the patient. The apparatus includes a housing adapted to be disposed in the patient. The housing has disposed in it a stimulator in electrical communication with at least the first electrode to stimulate the first electrode with either current or voltage, a sensor in electrical communication with at least the second electrode to sense a response from the second electrode based on the stimulation of the first electrode, and a signal processor in electrical communication with the sensor to determine the complex electrical admittance or impedance of the patient.

Abstract: Compositions and methods of synthesis of anionic surfactants by alkoxylation of a Guerbet alcohol (GA) having 12 to 36 carbon atoms using butylene oxide, and optionally propylene oxide and/or ethylene oxide followed by the incorporation of a terminal anionic group are described herein. The GA of the present invention is made by a facile and inexpensive method that involves high temperature base catalyzed dimerization of alcohols with 6 to 18 carbon atoms. The large hydrophobe ether surfactants of the present invention find uses in enhanced oil recovery (EOR) applications where it is used for solubilization and mobilization of oil and for environmental cleanup. Further, the hydrophobe alkoxylated GA without anionic terminal group can be used as an ultra-high molecular weight non-ionic surfactant.

Abstract: Fabricating a nanofiber ribbon or sheet with a process that includes providing a primary assembly by arranging carbon nanotube nanofibers in aligned arrays, the arrays having a degree of inter-fiber connectivity, drawing the carbon nanotube nanofibers from the primary assembly into a sheet or ribbon, and depositing the sheet or ribbon on a substrate.

Abstract: Photovoltaic devices and methods of making the same, are disclosed herein. The cell comprises a photovoltaic device that comprises a first electrically conductive layer comprising a photo-sensitized electrode; at least one photoelectrochemical layer comprising metal-oxide particles, an electrolyte solution comprising at least one asphaltene fraction, wherein the metal-oxide particles are optionally dispersed in a surfactant; and a second electrically conductive layer comprising a counter-electrode, wherein the second electrically conductive layer comprises one or more conductive elements comprising carbon, graphite, soot, carbon allotropes or any combinations thereof.

Abstract: Provided herein are systems, methods, and compositions for the thermal imaging of cells with nanoparticles.

Abstract: Disclosed are various embodiments for a power stage that can drive various types of loads. The power stage includes a first capacitor and a second capacitor that are coupled to the load. The power stage also includes switches that are operable in a first power stage state and a second power stage state. When the switches are in the first power stage state, the first capacitor discharges to the load, and the second capacitor charges. When the switches are in the second power stage state, the second capacitor discharges to the load, and the first capacitor charges.

Abstract: A sensor for detecting one or more materials includes a substrate, a passivation layer formed on the substrate, a self-resonant structure and a high surface area material disposed on the passivation layer. The self-resonant structure includes a planar spiral inductor and a plurality of planar interdigitated capacitor electrodes disposed within the passivation layer. The planar spiral inductor includes an electrically conductive trace formed on the substrate in a planar spiral pattern having at least two turns and an inter-winding space between parallel segments of the electrically conductive trace. The plurality of planar interdigitated capacitor electrodes are electrically connected to the electrically conductive trace of the planar spiral inductor and formed on the substrate within the inter-winding space of at least one outermost turn of the planar spiral inductor. The high surface area material includes a conformal polymer coating to increase a sensitivity to the one or more materials.

Abstract: A method and apparatus for detects one or more subsurface targets by receiving a reflectivity data from two or more subsurface reflectors using a ground penetrating radar. The two or more subsurface reflectors may include the one or more subsurface targets and a medium surrounding the one or more subsurface targets. An impedance data for the two or more subsurface reflectors is calculated by inverting the reflectivity data using a temporal transmission line model with a “layer-peeling” method. One or more constitutive parameters of the two or more subsurface reflectors are calculated based on the impedance data. The one or more subsurface targets are detected based on a change in the one or more constitutive parameters.

Abstract: A method, system and computer program product for efficiently identifying images, videos, audio files or documents relevant to a user. Using either manual annotations or learned functions, the method predicts the relative strength of an attribute in an image, video, audio file or document from a pool of images, videos, audio files or documents. At query time, the system presents an initial set of reference images, videos, audio files or documents, and the user selects among them to provide relative attribute feedback. Using the resulting constraints in the multi-dimensional attribute space, the relevance function for the pool of images, videos, audio files or documents is updated and the relevance of the pool of images, videos, audio files or documents is re-computed. This procedure iterates using the accumulated constraints until the top-ranked images, videos, audio files or documents are acceptably close to the user's envisioned image, video, audio file or document.

Abstract: A spintronic device and a method for making said spintronic device. The spintronic device includes an epitaxial crystalline ferromagnetic oxide formed directly on the semiconductor material thereby allowing spin-polarized current to be efficiently injected from the ferromagnetic oxide into the semiconductor material. A host crystal lattice includes multiple sets of stacked oxide layers of material A and B of a perovskite structure with a formula of ABO3. After an oxide layer of B is grown, magnetic ions are introduced to intermix with the B material, which may replace some of the ions of the B material. The process of growing additional stacked oxide layers of material A and B and introducing further magnetic ions after the deposition of the oxide layer of B continues until enough magnetic ions are sufficiently close to one another that they align in the same direction thereby forming a ferromagnetic oxide on the semiconductor material.

Abstract: Stable aqueous solutions comprising concentrations of baclofen in the range of greater than 2.0 mg/mL up to about 10 mg/mL are disclosed. These solutions can be used as pharmaceuticals for parenteral or oral administration. The invention also provides methods of preparing said stable aqueous baclofen solutions.

Abstract: A vertical-mode tunnel field-effect transistor (TFET) is provided with an oxide region that may be laterally positioned relative to a source region. The oxide region operates to reduce a tunneling effect in a tunnel region underlying a drain region, during an OFF-state of the TFET. The reduction in tunneling effect results in a reduction or elimination of a flow of OFF-state leakage current between the source region and the drain region. The TFET may have components made from group III-V compound materials.