Patents Assigned to Board of Regentsm The University of Texas System
  • Oncolytic adenovirus armed with therapeutic genes
    Patent number: 9061055
    Abstract: The present invention involves compositions and methods for treating cancer using a mutant adenovirus comprising a polynucleotide encoding a therapeutic polypeptide that is targeted to cells with a mutant retinoblastoma pathway. The mutant adenovirus is able to kill the tumor cells without harming cells with a wild type retinoblastoma pathway.
    Type: Grant
    Filed: February 12, 2009
    Date of Patent: June 23, 2015
    Assignee: Board of Regentsm The University of Texas System
    Inventors: Juan Fueyo, Candelaria Gomez-Manzano, W.K. Alfred Yung, Charles A. Conrad, Frederick F. Lang, Jr.