Abstract: Expression of the E4 orf 1 gene of Ad-36 alone has been discovered to be responsible for the increased insulin sensitivity observed in Ad-36 infected animals, including increased adipogenesis. Ad-36 E4 orf 1 protein can be used to increase insulin sensitivity and ameliorate diabetes. Additionally, drugs that mimic the action of Ad-36 E4 orf 1 protein could be found. Ad-36 E4 orf 1 could also be used to increase fat cells in lipodystrophy. We have also discovered that Ad-36 infection in human skeletal muscle cells increased differentiation and insulin independent glucose uptake. It is expected that infection with Ad-36 E4 orf 1 gene will also cause these effects.
Type:
Grant
Filed:
November 30, 2006
Date of Patent:
August 30, 2011
Assignees:
Wayne State Univeristy, Board of Sup. of LSU and Agr. & Mechanical College
Inventors:
Nikhil V. Dhurandhar, Thomas C. Holland, Zhong Q. Wang