Patents Assigned to Board of Supervisors of Louisiana State University acting on behalf of the University of Louisiana at Monroe
  • Inhibitors of metastasis, methods of generating such inhibitors and their therapeutic applications
    Patent number: 9765115
    Abstract: The chain of events that explains calcitonin receptor (CTR)-stimulated invasion and metastasis of prostate cancer cells was identified. The CTR-stimulated events depend on the interaction of CTR with the PDZ3 domain of ZO-1. Small peptides and small molecules were identified that inhibit this interaction. The small inhibitory peptides were synthesized and can be used to attenuate or inhibit metastasis in solid cancer tumors.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: September 19, 2017
    Assignee: Board of Supervisors of Louisiana State University acting on behalf of the University of Louisiana at Monroe
    Inventor: Girish V. Shah