Abstract: Compositions of either the Rm86Texas protein from a Texas outbreak strain of the southern cattle fever tick, Rhipicephalus microplus, or a nucleic acid construct incorporating a nucleic acid sequence encoding this Rm86Texas protein, are effective for eliciting a protective immune response in non-bovine animals. The Rm86Texas protein is immunogenic and can be administered as a protein vaccine, or in the alternative, the nucleic acid construct can be utilized as a DNA vaccine. Induction of the immune response significantly reduces or eliminates the infestation of treated, non-bovine animals with ticks. Moreover, as ticks are vectors of a variety of pathogens, the reduction in the incidence of tick infestation afforded by the vaccines may concurrently reduce the incidence of diseases caused by these pathogens in susceptible animals.
Type:
Grant
Filed:
September 18, 2017
Date of Patent:
July 30, 2019
Assignees:
The United States of America, as Represented by the Secretary of Agriculture, Board of Supervisors of Louisiana State University and Agriculture and Mechanical Colloge
Inventors:
Andrew Y. Li, Felicito Guerrero, Lane D. Foil, Adalberto A. Perez De Leon