Abstract: Disclosed are a platinum (II) complex of N-substituted amino dicarboxylate showing antitumor activity represented by the following formula (1) and a preparation method thereof: wherein n is 1 or 2; A—A is a diamine selected from the group consisting of trans-(±)-1,2-diaminocyclohexane, ethylenediamine and 2,2-dimethyl-1,3-propanediamine; and R1 is hydrogen and R2 is RCO or RSO2, wherein R is an alkyl selected from the group consisting of methyl, ethyl, n-propyl, n-butyl and t-butyl or an aryl selected from the group consisting of phenyl and substituted phenyl group, or R1R2 is phthaloyl.
Type:
Grant
Filed:
January 8, 2004
Date of Patent:
March 15, 2005
Assignee:
Board of Trustees, Ewha Womans University
Inventors:
Youn Soo Sohn, Yeong-Sang Kim, Rita Song
Abstract: Disclosed are a platinum (II) complex of N-substituted amino dicarboxylate showing antitumor activity represented by the following formula (1) and a preparation method thereof: 1
Type:
Application
Filed:
January 8, 2004
Publication date:
August 19, 2004
Applicant:
Board of Trustees, EWHA Womans University
Inventors:
Youn Soo Sohn, Yeong-Sang Kim, Rita Song