Patents Assigned to Board of Trustees of Leland S. Stanford, Jr. University
  • Patched genes and uses related thereto
    Patent number: 6946257
    Abstract: Methods are provided for identifying agents that decrease hedgehog signal transduction for ameliorating an effect of loss of function of a patched gene in a mammalian cell.
    Type: Grant
    Filed: August 21, 1997
    Date of Patent: September 20, 2005
    Assignees: Regents of the University of California, Board of Trustees of the Leland S. Stanford, Jr. University
    Inventors: Matthew P. Scott, Lisa V. Goodrich, Ronald L. Johnson, Ervin Epstein, Jr.
  • Regulated transcription of targeted genes and other biological events
    Patent number: 6063625
    Abstract: Dimerization and oligomerization of proteins are general biological control mechanisms that contribute to the activation of cell membrane receptors, transcription factors, vesicle fusion proteins, and other classes of intra- and extracellular proteins. We have developed a general procedure for the regulated (inducible) dimerization or oligomerization of intracellular proteins. In principle, any two target proteins can be induced to associate by treating the cells or organisms that harbor them with cell permeable, synthetic ligands. To illustrate the practice of this invention, we have induced: (1) the intracellular aggregation of the cytoplasmic tail of the .zeta.
    Type: Grant
    Filed: September 16, 1998
    Date of Patent: May 16, 2000
    Assignees: Board of Trustees of Leland S, Stanford, Jr. University, President and Fellows of Harvard College
    Inventors: Gerald R. Crabtree, Stuart L. Schreiber, David M. Spencer, Thomas J. Wandless, Steffan N. Ho, Peter Belshaw
  • Regulated transcription of targeted genes and other biological events
    Patent number: 5869337
    Abstract: Dimerization and oligomerization of proteins are general biological control mechanisms that contribute to the activation of cell membrane receptors, transcription factors, vesicle fusion proteins, and other classes of intra- and extracellular proteins. We have developed a general procedure for the regulated (inducible) dimerization or oligomerization of intracellular proteins. In principle, any two target proteins can be induced to associate by treating the cells or organisms that harbor them with cell permeable, synthetic ligands. To illustrate the practice of this invention, we have induced: (1) the intracellular aggregation of the cytoplasmic tail of the .zeta.
    Type: Grant
    Filed: February 14, 1995
    Date of Patent: February 9, 1999
    Assignees: President and Fellows of Harvard College, Board of Trustees of Leland S. Stanford Jr. University
    Inventors: Gerald R. Crabtree, Stuart L. Schreiber, David M. Spencer, Thomas J. Wandless, Peter Belshaw
  • Regulated transcription of targeted genes and other biological events
    Patent number: 5830462
    Abstract: Dimerization and oligomerization of proteins are general biological control mechanisms that contribute to the activation of cell membrane receptors, transcription factors, vesicle fusion proteins, and other classes of intra- and extracellular proteins. We have developed a general procedure for the regulated (inducible) dimerization or oligomerization of intracellular proteins. In principle, any two target proteins can be induced to associate by treating the cells or organisms that harbor them with cell permeable, synthetic ligands. To illustrate the practice of this invention, we have induced: (1) the intracellular aggregation of the cytoplasmic tail of the .zeta.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 3, 1998
    Assignees: President & Fellows of Harvard College, Board of Trustees of Leland S. Stanford, Jr. University
    Inventors: Gerald R. Crabtree, Stuart L. Schreiber, David M. Spencer, Thomas J. Wandless, Peter Belshaw