Abstract: A system and method for MR imaging includes the use of a form of autocalibrated parallel imaging. By combining a segmented, rotated acquisition trajectory with autocalibration parallel imaging (API), the system and method can achieve improved motion insensitivity while maintaining the benefits of accelerated acquisition due to parallel imaging. In various embodiments, calibration values from a set of reference data or from another set of imaging data can be used in determining reconstruction weights for a given k-space data set. Thus, separate calibration data need not necessarily be acquired for each set of imaging data.

Abstract: The present invention provides methods of detecting asymmetric dimethylarginine (ADMA) in a sample, particularly a sample that may contain symmetrical dimethylarginine (SDMA) and/or arginine. The methods generally involve modifying any SDMA and arginine in the sample such that SDMA and arginine are readily distinguishable from ADMA; and detecting ADMA. The invention further provides antibodies specific for ADMA; antibodies specific for modified SDMA; and antibodies specific for modified arginine. The invention further provides kits for practicing the subject methods.

Abstract: An RF coil assembly includes a plurality of RF source coils and an RF target coil separate from the plurality of RF source coils. A computer is programmed to acquire MR data of an imaging object from each of the plurality of RF source coils and to acquire MR data of the imaging object from the RF target coil. The computer is further programmed to calculate a set of weights based on a relationship between MR data acquired from each RF source coil and MR data acquired from the RF target coil and to reconstruct an image based on an application of the set of weights to at least a portion of the MR data acquired from each of the plurality of RF source coils.

Abstract: The present invention provides a system and method for parallel imaging that performs auto-calibrating reconstructions with a 2D (for 2D imaging) or 3D kernel (for 3D imaging) that exploits the computational efficiencies available when operating in certain data “domains” or “spaces”. The reconstruction process of multi-coil data is separated into a “training phase” and an “application phase” in which reconstruction weights are applied to acquired data to synthesize (replace) missing data. The choice of data space, i.e., k-space, hybrid space, or image space, in which each step occurs is independently optimized to reduce total reconstruction time for a given imaging application. As such, the invention retains the image quality benefits of using a 2D k-space kernel without the computational burden of applying a 2D k-space convolution kernel.

Abstract: The present invention uses a Semidefinite Programming (SDP) relaxation based method for the position estimation problem in sensor networks wherein the original problem is converted into a convex optimization problem. Estimation errors can be calculated, such that the quality of the solution to the initial problem is known. The sensor network may be divided into clusters such that the position estimation problem and the computation work can be distributed. The distributed scheme is highly scalable. A network with thousands of sensors may be solved within several minutes.

Abstract: A method for providing panoramic videos and images to a user using a server-client architecture while minimizing the wait time necessary before still images are available for viewing or videos begin playing. A series of location-referenced panoramic images are separated into one-dimensional tracks. Intuitive user controls are provided which allow the user to start and stop video playback, step through the panoramas in a track one at a time, and change the viewing orientation within the panorama. A video will start playing as soon as the video files for the preferred projected cube faces have been downloaded. This delay is reduced by storing the videos as keyframe distance files for opposing directions for each cube face and further reduced by encoding videos with different starting points so that they are staggered by a portion of the keyframe distance.

Abstract: A system and process for attaching tags to panoramic video. Tags provide information when viewing panoramic images, serve as references to specific actions and serve as reference for outside systems into a panoramic image database. Objects in a video can be tagged. It defines tags through 4-D time-space curves, which specify the 3-D location of a tagged object over time. It provides a user-friendly mechanism for defining said curves in panoramic video, which rely on curve fitting techniques to minimize the number of images to be labeled. It provides a mechanism for annotating tags with further information. When displaying tagged panoramic video, tags are graphically superimposed on the panoramic video feed using projective projection techniques. From this visualization, a user can then select a given tag and invoke an associated action. Additionally a mechanism whereby tags and associated user-provided information are used as index into panoramic image databases is provided.

Abstract: A system and process of morphing location-referenced panoramic images into views at nearby locations. When using panoramic images in an interactive tour, a user might desire to see the environment from viewpoints for which no panoramic images are available. This invention makes this possible. It enables a user to experience views from arbitrary locations in the environment, so as long as one or more panoramic images are available at nearby locations. In particular, this invention makes it possible to combine two non-overlapping geo-referenced panoramic video streams into a new video stream which seamlessly transitions between these streams. When used in a client-server architecture, this invention also makes it possible for the server to transmit a sparse sequence of panoramic images, and provide the user with a dense panoramic video stream, by synthesizing the missing panoramic images. Said system and process is also applicable to incomplete panoramic images, photographs, and video.

Abstract: A method for forming an adaptive phased array transmission beam pattern at a base station without any knowledge of array geometry or mobile feedback is described. The approach is immune to the problems which plague methods which attempt to identify received angles of arrival from the mobile and map this information to an optimum transmit beam pattern. In addition, this approach does not suffer the capacity penalty and mobile handset complexity increase associated with mobile feedback. Estimates of the receive vector propagation channels are used to estimate transmit vector channel covariance matrices which form objectives and constraints in quadratic optimization problems leading to optimum beam former solutions for the single user case, and multiple user case. The new invention in capable of substantial frequency re-use capacity improvement in a multiple user cellular network.

Abstract: The present invention provides a system and method for parallel imaging that performs auto-calibrating reconstructions with a 2D (for 2D imaging) or 3D kernel (for 3D imaging) that exploits the computational efficiencies available when operating in certain data “domains” or “spaces”. The reconstruction process of multi-coil data is separated into a “training phase” and an “application phase” in which reconstruction weights are applied to acquired data to synthesize (replace) missing data. The choice of data space, i.e., k-space, hybrid space, or image space, in which each step occurs is independently optimized to reduce total reconstruction time for a given imaging application. As such, the invention retains the image quality benefits of using a 2D k-space kernel without the computational burden of applying a 2D k-space convolution kernel.

Abstract: This invention provides a method for treating or preventing arrhythmias in a human subject comprising the administration of an effective amount of a calcium/calmodulin-dependent protein kinase inhibitor. Also provided are pharmaceutical compositions comprising a calcium/calmodulin-dependent protein kinase inhibitor and a pharmaceutically acceptable carrier and methods for identifying agents useful for the treatment of arrhythmias.

Abstract: A system which seperates content into different streams, generally organized on a content subject matter basis. Inside each stream individual content items are ordered based on personal ordering criteria. The content item is analyzed and compared with the criteria to determine a predicted level of interest. A feedback process is preferred to develop the criteria. When a user is reviewing a content item, reviewing an entire item provides positive indications to various factors. To stop reviewing an item, the user can provide a termination indication, such as a JUMP key. Use of JUMP key provides negative indications for the various factors, with the timing scaling the negative indication, with a quicker indication having a higher negative value. These positive and negative indications are entered into a database to help update the personal ordering criteria. Existing entry values are modified and new entries are added with the indicated value.

Abstract: A method and system for producing graphics. A hierarchical structure of a database is determined. A visual table, comprising a plurality of panes, is constructed by providing a specification that is in a language based on the hierarchical structure of the database. In some cases, this language can include fields that are in the database schema. The database is queried to retrieve a set of tuples in accordance with the specification. A subset of the set of tuples is associated with a pane in the plurality of panes.

Abstract: Methods are provided for use in treating humans suffering from irritable bowel syndrome. In the subject methods, an effective amount of a nerve-acting agent, e.g., lidocaine, topiramate, mexiletine and gabapentin, etc., is administered to a human suffering from irritable bowel syndrome. Also provided are pharmaceutical compositions and kits for use in practicing the subject methods.

Abstract: ?v?3 Integrin receptor targeting liposomes comprise a cationic amphiphile such as a cationic lipid, a neutral lipid, and a targeting lipid. The targeting lipid includes a non-peptidic ?v?3 integrin antagonist.

Abstract: Materials and methods are disclosed for regulation of biological events such as target gene transcription and growth, proliferation or differentiation of engineered cells.

Abstract: This application discloses methods for diagnosing and treating SUI. The treatment methods are directed to inhibiting elastolysis in affected tissues and correcting imbalances in the expression of elastase enzymes and their inhibitors.

Abstract: A system and method are disclosed using continuous table motion while acquiring data to reconstruct MR images across a large FOV without significant slab-boundary artifacts that reduces acquisition time. At each table position, full z-encoding data are acquired for a subset of the transverse k-space data. The table is moved through a number of positions over the desired FOV and MR data are acquired over the plurality of table positions. Since full z-data are acquired for each slab, the data can be Fourier transformed in z, interpolated, sorted, and aligned to match anatomic z locations. The fully sampled and aligned data is then Fourier transformed in remaining dimension(s) to reconstruct the final image that is free of slab-boundary artifacts.

Abstract: A VLSI layout editor and method for using same that increases display and re-display speed and accuracy uses properties inherent to VLSI layouts that allows them to be displayed efficiently and accurately independent of the canonical expression of the VLSI design. The VLSI layout editor and methods for using same use precomputed images that each represent a portion of the VLSI layout, a hierarchy cache that includes multiple LOD versions of selected sub-designs in the pre-computed images, and selected direct determination of the viewable representation from the canonical expression for at least one LOD. Apparatus and methods according to the present invention can render a particular type of data whose canonical form is smaller than its corresponding displayed image thereof when the displayed image has geometric properties that allow heuristics and rasterization for dynamic and accurate expansion using selected combined techniques.

Abstract: TSG101 is a tumor susceptibility gene whose homozygous functional knock out in fibroblasts leads to transformation and the ability of these cells to form metastatic tumors in nude mice. The cellular transformation that results from inactivation of TSG101 is reversible by restoration of TSG101 function. Decreased expression of TSG101 is associated with the occurrence of certain human cancers, including breast carcinomas. The TSG101 nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of cancer, identification of cell type based on expression, and the like.