Patents Assigned to Board of Trustees of Southern lllinois University
  • Tuning CRISPR/CAS9 Activity with Chemically Modified Nucleotide Substitutions
    Publication number: 20190185844
    Abstract: The present disclosure provides CRISPR/Cas9 ribonucleoprotein compositions comprising chemically modified CRISPR RNA (crRNA) guide and trans-acting CRISPR RNA (tracrRNA) components. Methods of using the disclosed CRISPR/Cas9 ribonucleoprotein compositions are also provided.
    Type: Application
    Filed: September 22, 2017
    Publication date: June 20, 2019
    Applicants: Board of Trustees of Southern lllinois University, The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Keith GAGNON, Masad DAMHA, Elise MALEK-ADAMIAN, Maryam HABIBIAN, Daniel O'REILLY, Zachery KARTJE