Abstract: The present invention relates to the use of perylene diimide derivatives as air-stable n-type organic semiconductors.

Abstract: To reduce dislocations produced in the formation of shallow trench isolation regions in a semiconductor substrate, the semiconductor substrate is annealed in N2 ambient pressure with an O2 partial pressure of less than about 10−4 at a temperature between about 950 C.° and about 1055 C.°. In addition, a method to reduce crystalline defects in semiconductor manufacturing in which a metal is deposited on an insulator to form metal silicide is provided. The method provides for etching the insulator to create an overhang by an amount equal to at least one half of the thickness of the metal, thereby creating a void between the surface of the semiconductor substrate and the insulator. The metal is deposited on the first insulator and on the surface of the semiconductor substrate and the semiconductor substrate is heated thereby forming metal silicide on the surface of the substrate.

Abstract: Nucleic acid-based methods for the detection of Cyclospora are disclosed, including PCR-based and hybridization-based techniques.

Abstract: Dimerization and oligomerization of proteins are general biological control mechanisms that contribute to the activation of cell membrane receptors, transcription factors, vesicle fusion proteins, and other classes of intra- and extracellular proteins. We have developed a general procedure for the regulated (inducible) dimerization or oligomerization of intracellular proteins. In principle, any two target proteins can be induced to associate by treating the cells or organisms that harbor them with cell permeable, synthetic ligands. To illustrate the practice of this invention, we have induced: (1) the intracellular aggregation of the cytoplasmic tail of the .zeta.

Abstract: The present invention provides methods for treating mammalian cancer tumors, preferably solid tumors, comprising administering to a mammal in need of such treatment an effective amount of a 1,2,4-benzotriazine oxide as defined in Formula I or pharmacologically acceptable salts of said compound; and administering to the mammal from about one half hour to about twenty-four hours after administering the 1,2,4-benzotriazine oxide an effective amount of a chemotherapy agent to which the minor is susceptible. The invention also provides kits for treatment of such tumors which comprise a chemotherapy agent and a cytotoxicity-enhancing amount of a 1,2,4-benzotriazine oxide as defined in Formula I.

Abstract: The invention provides nucleic acids encoding one or more hyper-invasive genes within the hil locus (hyper-invasion locus) or fragments thereof, methods for making attenuated microorganisms and identifying such hyper-invasive nucleic acids as well as mutant microorganisms wherein one or more hyper-invasive genes within the hil locus are modified to attenuate the invasive phenotype of the microorganism. The methods of the invention utilize conditions which repress invasiveness in an otherwise invasive microorganism. The method comprises mutating an invasive microorganism to form a plurality of mutant microorganisms. The thus formed mutants are exposed to conditions which repress invasiveness of the parental invasive microorganism. At least one mutant microorganism is then detected which exhibits an increase in invasiveness as compared to the parental invasive microorganism.

Abstract: An electrostatic ultrasonic transducer formed on a semiconductor substrate by micro-machining wherein the transducer includes a silicon nitride membrane supported above the surface of the substrate by insulating supports; and the substrate and membrane define the electrodes of the transducer.

Abstract: DNA constructs are prepared which operably link human interferon genes, selective, eukaryotic marker genes, and promoter and expression control sequences for the expression of human interferon in Chinese hamster ovary (CHO) cells or progeny thereof. The human recombinant interferon so produced contains glycans which are a subset of the population of glycans which are contained in the native counterpart, and may be used in therapeutic formulations. The CHO cells yield high levels of human interferon with no detectable amounts of host, IFN, either constitutive or inductive.

Abstract: A Monolithic Microwave Integrated Circuit (MMIC) for capturing transients in the GHz range is disclosed. The device includes a transmission line formed in a GaAs substrate. The transmission line includes a number of threshold devices forming shunts on the transmission line. The threshold devices are positioned at predetermined locations with respect to one another. A reference signal and an unknown signal are counter-propagated along the transmission line. When the two signals collide, they produce a collision voltage which exceeds the threshold voltage of the threshold devices. The voltage information is distributed along the predetermined length of several threshold devices. Thus, amplitude, phase, and timing information regarding the two signals may be obtained. This information may be utilized for triggering, clock interpolation, data demodulation, and other applications.

Abstract: Sensitive detection techniques and compositions for such techniques are provided by employing fluorescent proteins having bilin prosthetic groups as labels. The bilin containing proteins can be conjugated to ligands or receptors for use in systems involving ligand-receptor binding for the analysis, detection or separation of ligands and receptors. Particularly, one or more of the bilin containing proteins may be used as labels in conjunction with each other or other fluorescers for defining subsets of naturally occurring aggregations e.g. cells.

Abstract: Nucleic acids and peptides are provided which can be used for detecting the status of functional T-lymphocytes as to stimulation and the time of stimulation. The nucleic acids and peptides may be provided by cloning and expression using recombinant techniques. These diagnoses may be used to determine whether T-cells are functional and the degree to which a T-cell population has been stimulated.

Abstract: An electronic drum has two or more batons, each baton having a transmitter which transmits a distinct radio frequency signal at a position in space. The electronic drum determines the current X, Y, and Z coordinates of each baton transmitter. To determine the position of each baton transmitter, the drum includes a tablet which has a flat support member at a predefined position, with at least two pairs of electrodes coupled to the flat support member. A first pair of the electrodes is shaped so that the amount of capacitive coupling between each baton transmitter and one of the first pair of electrodes corresponds to the position of the baton transmitter with respect to the X axis. A second pair of electrodes is shaped so that the amount of capacitive coupling between each baton transmitter and one of the second pair of electrodes corresponds to the position of the baton transmitter with respect to the Y axis.

Abstract: A method and system for localizing a diagnostic or therapeutic agent to an internal target site. The system includes (1) an epitopic compound, (2) a binding protein which is effective to bind specifically with the compound and capable of localizing selectively at the target tissue, when administered parenterally, and (3) a clearing agent which can bind to and cross-link the binding protein, to form a protein aggregate which is readily cleared from the subject's bloodstream. In practicing the method of the invention, the binding protein is administered to the subject parenterally, and allowed to localize at the target site, typically within 1-4 days. This is followed by a chase with the clearing agent to remove circulating, but not target-localized binding protein. When the epitopic compound is administered, binding of the compound to the localized binding protein, and rapid clearance of unbound compound by the kidneys, results in selective localization of the compound at the target site.

Abstract: Fluorescent conjugates are employed providing combinations of a fluorescent sensitizer and a fluorescent phycobiliprotein. The conjugates find use in applications where large Stokes shifts, high absorption coefficients and high fluorescence quantum yields are desired. Particularly, combinations of phycobiliproteins are employed where the wavelength of excitation may be 50 nm or more different from the emission wavelength.

Abstract: A fiber optic sensor comprises a length of optical fiber, forming a loop, and a fiber optic directional coupler for optically closing the loop. The loop and coupler form a resonant cavity for light circulating therethrough. A PZT cylinder, about which the fiber loop is wrapped, is utilized to control the total round trip phase delay of the circulating light, and thus, control the intensity of the optical output signal. The phase delay is adjusted to a point where the optical output signal is at maximum sensitivity to changes in phase. When the fiber loop is exposed to, e.g., acoustic waves, the loop length changes correspondingly, thereby causing the phase delay, and thus, the optical output signal to vary. By detecting variations in output signal intensity, the frequency and intensity of the acoustic waves may be determined. The sensor also includes a feedback system for stabilizing the fiber loop against low frequency thermal drift.

Abstract: A fiber optic rotation sensor utilizes multimode optical fiber to improve power coupling and reduce coherent back scattering. A multimode light source such as a light emitting diode can be used. The system is economical and environmentally stable.

Abstract: Fiber optic device for controlling the state of polarization of light. In one embodiment, a strand of fiber optic material is bent into a generally planar coil of relatively tight radius to stress the material and form a birefringent medium having principal axes which are rotated to control the polarization of light passing through the strand. In a second embodiment, one portion of a fiber optic strand is twisted about its axis to change the polarization, and a second portion of the strand is formed into a coil which is free to change in radius without additional twisting as the first portion is twisted.

Abstract: An electrical circuit device made in integrated monolithic form has low level operating characteristics of a MOS device and high level operating characteristics of a Triac. The structure includes two double diffused MOS transistors which have merged drain regions. At higher voltage and current levels a lateral Triac structure is triggered by the MOS devices. Alternatively, separate terminal contacts can be made to the P and N regions comprising the MOS transistor source and channel regions with the Triac triggered conventionally by an externally applied control voltage.