Abstract: Endothelial cells derived from subcutaneous adipose tissue are genetically modified to express the endothelial cell-specific angiogenic factor VEGF. The modified cells are sodded onto a vascular prosthesis for transplantation into an autologous or allogeneic recipient. The method accelerates endothelialization on the luminal surface of the vessel, and promotes collateral circulation in distal ischemic organs.
Type:
Grant
Filed:
May 15, 1996
Date of Patent:
July 28, 1998
Assignee:
The Board of Trustees of the Leland Stanford Junior Univ.
Abstract: Methods and compositions are described for modulating trafficking of leukocytes to endothelial cells involving the binding of homing receptors and addressins. Particularly, compositions are provided which can inhibit the interaction between the homing receptor and addressin or provide for directing specific molecules associated with diagnosis or treatment, where the molecules bind to the addressins.
Type:
Grant
Filed:
December 19, 1991
Date of Patent:
July 23, 1996
Assignee:
The Board of Trustees for the Leland Stanford Junior Univ.
Inventors:
Eugene C. Butcher, Philip R. Streeter, Ellen L. Berg
Abstract: DNA and protein compositions are provided for calcium-signal modulating cyclophilin ligand which are shown to act in the calcium-dependent pathway for activation of a number of genes. The DNA composition and proteins may be used in investigating the processes associated with calcium-dependent activation of genes, as well as screening of drugs for interaction with the subject proteins for modulating cell processes, e.g. T-cell activation.
Type:
Grant
Filed:
June 17, 1994
Date of Patent:
June 4, 1996
Assignee:
The Board of Trustees of the Leland Stanford Junior Univ.
Abstract: An alkylative cycloaddition method is provided that is particularly useful for the synthesis of many of the Vitamin D analogues with differing side chains. Thus, a preferred synthesis is of Vitamin D analogues having a side chain R.sub.1 where a first precursor having the structure ##STR1## with X being a halide or a pseudo halide, and a second precursor are provided, the second precursor being a 1,7 enyne. These precursors are reacted in the presence of a palladium catalyst to form compounds having the structure ##STR2## where R.sub.2 is hydrogen, hydroxyl, lower alkoxy, fluorine, or a protecting group, and R.sub.3 is hydrogen, hydroxyl, lower alkoxy, fluorine, or a protecting group.
Type:
Grant
Filed:
December 23, 1993
Date of Patent:
August 29, 1995
Assignee:
Board of Trustees of the Leland Stanford Junior Univ.
Abstract: Homogeneous catalyst systems are provided for cyclopolymerization of diolefins, particularly 1,5-hexadiene, which control the stereochemistry, microstructure, and physical properties of the polymers synthesized. The systems comprise homogeneous Ziegler-Natta catalysts based on group 4 metallocenes and methylalumoxane. The cyclopolymers synthesized exhibit different degrees of stereoregularity, which is a function of the polymerization conditions. In addition, the polyolefins can be chiral and optically active. The polymers produced are of high molecular weight and highly flexible.
Type:
Grant
Filed:
December 19, 1989
Date of Patent:
April 14, 1992
Assignee:
Board of Trustees of the Leland Stanford Junior Univ.
Abstract: Methods and apparatus are shown for cladding grown single crystal optical fibers. Neodymium YAG fibers are clad with a high index glass, either melted around the fiber in a trough or extruded over the fiber surface. Lithium niobate fibers are clad through an impregnation process. The lithium niobate fiber is first coated with magnesium oxide and then heated to a temperature and for a time sufficient for the magnesium oxide dopant material to diffuse into the fiber. The dopant lowers the intrinsic refractive indices of the fiber material around its circumference, creating a cladding region around the fiber core. Single crystal fibers clad by these methods and combined with suitable pumping means or with deposited electrodes provide low-loss single mode optical components useful for amplification, electro-optical effects and acousto-optical effects.
Type:
Grant
Filed:
February 28, 1990
Date of Patent:
December 31, 1991
Assignee:
The Board of Trustees of the Leland Stanford Junior Univ.
Inventors:
Robert L. Byer, Amado Cordova, Michael Digonnet, Martin Fejer, Celestino Gaeta, Herbert J. Shaw, Shoichi Sudo