Abstract: Methods and apparatuses to non-destructively and periodically sample a small quantity of intracellular proteins and mRNA from the same single cell or cells for an extended period of time. Specifically, describe herein are non-perturbative methods for time-resolved, longitudinal extraction and quantitative measurement of intracellular proteins and nucleic acids from a variety of cell types using systems including nanostraws.
Type:
Application
Filed:
September 13, 2017
Publication date:
November 28, 2019
Applicant:
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNVERSITY
Inventors:
Nicholas A. MELOSH, Yuhong CAO, Karl Martin HJORT, Amanda JONSSON
Abstract: Embodiments of the invention are related to leukemia inhibitory factor (LIF) for use in repressing human papillomavirus (HPV) transcription. Processes and related kits are described for treating a HPV-associated papillomatous proliferation, for treating a HPV-associated genital, anal, vulvar, penile, oral, or laryngeal wart, for treating HPV-associated cervical dysplasia or cervical cancer, and for repressing HPV transcription, by administering LIF to a patient in need thereof. A related embodiment is treatment of HPV-16 by use of LIF.
Type:
Application
Filed:
June 23, 2011
Publication date:
January 26, 2012
Applicant:
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNVERSITY
Inventors:
Joseph M. Bay, Bruce K. Patterson, Nelson Teng
Abstract: A novel zinc finger transcription factore (RFLAT-1) and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including diagnostic and therapeutic agent screening applications, as well as in treatment therapies. Also provided are methods of treating disease conditions associated with RANTES function, e.g. inflammation, and the like.
Type:
Grant
Filed:
January 27, 2000
Date of Patent:
April 23, 2002
Assignee:
Board of Trustees of the Leland Stanford Junior
Unversity
Inventors:
An M. Song, Ya-Fen Chen, Alan M. Krensky
Abstract: MRI Apparatus for obtaining a spin-echo signal applies a self-refocusing RF pulse with variable delay in the spin-echo signals following application of the RF pulse. The RF pulse is designed using the Shinnar-LeRoux algorithm B.sub.1 (t)=SLR.sup.-1 {A.sub.n (z), B.sub.n (z) } with A.sub.n '(z) substituted for A.sub.n (z).A.sub.n '(z) is slightly non-minimum phase and equals P(z) A.sub.n (z) where P(z) is a unit amplitude phase function chosen to compensate the phase of B.sub.n (z). The RF pulse can be designed for a specific delay, a specific power constraint, and small tip angle.
Type:
Grant
Filed:
July 27, 1992
Date of Patent:
January 18, 1994
Assignee:
Board of Trustees of the Leland Stanford Junior Unversity
Abstract: Production of alkali metal tetracarbonylferrates by reaction of alkali metal with an iron carbonyl, preferably iron pentacarbonyl, in a suitable solvent and in the presence of an electron carrier, the alkali metal being present in the liquid phase. Also, solvated forms of alkali metal tetracarbonylferrates as new compositions of matter. The alkali metal tetracarbonylferrates are useful in the production of aldehydes, ketones, acids, esters and amides.
Type:
Grant
Filed:
June 11, 1973
Date of Patent:
October 12, 1976
Assignee:
The Board of Trustees of Leland Stanford Junior Unversity