Abstract: The invention relates to pyridinyl nicotinic acetylcholine receptor ligands, compositions comprising an effective amount of a pyridinyl nicotinic acetylcholine receptor ligand and methods to treat or prevent a condition, such as depression and nicotine dependence, comprising administering to an animal in need thereof an effective amount of a pyridinyl nicotinic acetylcholine receptor ligand.

Abstract: Methods for isolating and identifying genetic elements that are capable of inhibiting gene function are disclosed, as well as genetic elements isolated or identified according to the method of the invention and host cells modified by genetic modification using genetic suppressor elements according to the invention.

Abstract: A multiple-product reentrant line scheduling method includes the steps of storing a time measurement variable for each one of a plurality of incomplete products disposed in a buffer at a workstation, the time measurement variable representing the entry of the incomplete product into the reentrant line, storing a time measurement variable for the buffer representing the time remaining for incomplete products of the same product type disposed in the buffer to be completed, calculating the difference between the stored time measurement variable for each incomplete product and the stored time measurement variable for the buffer to generate a slack variable for each incomplete product, normalizing the slack variable for each incomplete product by comparing the slack variable of each incomplete product with the slack variables for all incomplete products of same product type that have passed through the workstation to generate a selection variable for each incomplete product, comparing the selection variables to se