Abstract: The blood-brain barrier penetrant procaspase-3-activating drug, PAC-1, has been identified as an effective approach to inducing immune stimulatory destruction of cancer cells. PAC-1 induces cleavage of MLH1 in cancer cells, and studies show that inactivation of MLH1 leads to increased mutational burden and neoantigen presentation by major histocompatibility complex (MHC) products. Herein is described a mechanistic-based strategy to bring the power of immunotherapy in an effective fashion for treatment of cancer.
Type:
Application
Filed:
June 1, 2020
Publication date:
July 21, 2022
Applicant:
The Board of Trustees of the University of Illinois
Inventors:
Paul J. HERGENROTHER, Timothy M. FAN, Matthew BOUDREAU, William MONTGOMERY, Hyang-Yeon LEE, Marlies HAGER, Diana RANOA, Myung-ryul LEE
Abstract: Disclosed are devices, systems, and methods for restoring vision to a subject. In one embodiment, the vision restoration device comprises a projector configured to project one or more digital images onto a central retina of the subject and one or more lenses coupled to the projector and configured to focus the one or more digital images. The vision restoration device can also comprise an extraocular component configured to be implanted within the subject and comprising one or more processors programmed to execute instructions stored in a memory to wirelessly receive the one or more digital images from an extracorporeal device. The intraocular projection component can be connected or coupled to the extraocular component by a trans-scleral communication wire configured to cross the sclera of the eye. The trans-scleral communication wire is configured to transmit digital data between the extraocular component and the intraocular projection component.
Type:
Grant
Filed:
March 5, 2020
Date of Patent:
July 5, 2022
Assignee:
Board of Trustees of the University of Illinois
Inventors:
Charles Yu, Mark Rosenblatt, Songbin Gong, Sarah Yoonji Shim
Abstract: A method of forming a textured surface layer along a substrate that includes disposing a plurality of polymer spheres on a surface of the metal substrate, and electroplating the metal substrate at a current density to deposit a metal layer along a body of each of the plurality of polymer spheres disposed on the surface of the metal substrate. The metal layer does not extend above a top surface of the plurality of polymer spheres. The method further includes removing the plurality of polymer spheres from the metal layer to form the textured surface defined by a size and shape of the plurality of polymer spheres.
Type:
Grant
Filed:
November 26, 2019
Date of Patent:
July 5, 2022
Assignees:
TOYOTA MOTOR ENGINEERING & MANUFACTURING NORTH AMERICA, INC., THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
Inventors:
Shailesh N. Joshi, Paul Braun, Julia Kohanek, Gaurav Singhal
Abstract: Synthetic histatins composed of combinations of functional domains of natural histatins separated by exogenous linkers are described as are methods of using endogenous and synthetic histatins for the treatment of ocular diseases or conditions.
Type:
Grant
Filed:
September 3, 2020
Date of Patent:
June 28, 2022
Assignee:
The Board of Trustees of the University of Illinois
Abstract: Thermal management systems include a heat generating device that is to be kept within a desired temperature range. A thermoregulating layer coats, or is otherwise positioned in adjacent proximity to the heat generating device. The thermoregulating layer includes a Ni—Mn based Heusler alloy that exhibits an unprecedented differential in thermal conductivity across a relevant temperature range, based on a martensitic transition from an asymmetric lattice structure to a symmetric lattice structure with increasing temperature.
Type:
Grant
Filed:
January 31, 2019
Date of Patent:
June 28, 2022
Assignees:
Toyota Motor Engineering & Manufacturing North America, Inc., The Board of Trustees of the University of Illinois
Inventors:
Gaohua Zhu, Qiye Zheng, Debasish Banerjee, David G. Cahill
Abstract: The present invention is a multivalent immunogenic composition for immunizing an animal against filariasis. In some embodiments, the antigens of the multivalent immunogenic composition are protein-based, DNA-based, or a combination thereof. This invention also provides a method and kit for detecting a filarial nematode and determining vaccine efficacy.
Type:
Grant
Filed:
February 13, 2020
Date of Patent:
June 28, 2022
Assignee:
The Board of Trustees of the University of Illinois
Abstract: The present disclosure provides a system for monitoring unstructured environments. A predetermined path can be determined according to an assignment of geolocations to one or more agronomically anomalous target areas, where the one or more agronomically anomalous target areas are determined according to an analysis of a plurality of first images that automatically identifies a target area that deviates from a determination of an average of the plurality of first images that represents an anomalous place within a predetermined area, where the plurality of first images of the predetermined area are captured by a camera during a flight over the predetermined area. A camera of an unmanned vehicle can capture at least one second image of the one or more agronomically anomalous target areas as the unmanned vehicle travels along the predetermined path.
Type:
Application
Filed:
November 9, 2021
Publication date:
June 23, 2022
Applicant:
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
Inventors:
Girish Chowdhary, Chinmay P. Soman, Beau David Barber
Abstract: This invention is benzothiophene-based estrogen receptor downregulators and their compositions and uses to treat estrogen-related medical disorders.
Type:
Application
Filed:
July 26, 2021
Publication date:
June 23, 2022
Applicant:
The Board of Trustees of the University of Illinois
Inventors:
Gregory R. Thatcher, Rui Xiong, Jiong Zhao, Debra A. Tonetti
Abstract: Genetically modified pigs having at least one cancer and/or at least one co-morbid condition are provided. Also provided are methods of using the pig and derived tumor cells to screen for therapeutic compounds, medical devices or procedures, and/or combinations thereof. Further provided are methods of producing personalized cancer models, including obtaining a tumor sample from a subject, identifying mutations in the tumor sample, and producing a genetically modified tumor or tumor cell line having the same mutations.
Type:
Application
Filed:
March 3, 2020
Publication date:
June 16, 2022
Applicant:
The Board of Trustees of the University of Illinois
Inventors:
Lawrence B. Schook, Ron C. Gaba, Regina M. Schwind, Kyle Schachtschneider
Abstract: This disclosure provides methods, reagents, and diagnostic and prognostic markers useful for non-invasive identification, diagnosis, and therapeutic intervention in individuals with epilepsy. More particularly, the disclosure uses specific metabolites measured by magnetic resonance spectroscopy in brain tissue to detect epileptic brain regions.
Type:
Grant
Filed:
June 20, 2018
Date of Patent:
June 7, 2022
Assignee:
The Board of Trustees of the University of Illinois
Abstract: An analog self-interference cancellation technique for In-Band Full-Duplex (IBFD) systems generates an inherent secondary self-interference (SI) signal of a circulator and uses that signal to cancel a primary SI signal leaked from a transmitter port within a communication device. The communication device manipulates the phase and angle of this secondary SI, using an adjustable Impedance Mismatch Terminal (IMT) circuit. The result is an efficient SI cancellation technique in the analog domain, which uses the circulator inherent SI signals.
Type:
Grant
Filed:
May 24, 2018
Date of Patent:
June 7, 2022
Assignee:
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
Abstract: The present disclosure provides methods for detection and quantification of trimethylamine (TMA) or trimethylamine oxide (TMAO) comprising passing a sample over a sensor comprising a substrate having a plurality of chemically responsive dyes selected from the following classes of chemically responsive dyes: metal-containing dyes, pH indicators, or solvatochromic/vapochromic dyes. The disclosure also provides devices and sensors for the detection and quantification of TMA, and methods of diagnosing a subject having trimethylaminuria (TMAU).
Type:
Grant
Filed:
May 17, 2017
Date of Patent:
May 31, 2022
Assignee:
The Board of Trustees of the University of Illinois
Inventors:
Kenneth S. Suslick, Zheng Li, Maria K. LaGasse
Abstract: The therapies described herein can be selectively lethal toward a variety of different cancer cell types and cancer conditions in a subject. The combination therapies described herein can be useful for the management, treatment, control, or adjunct treatment of diseases, where the selective lethality is beneficial in immunotherapy, particularly where the disease is accompanied by elevated levels of NQO1. In particular, embodiments where an immunotherapy, such as a heckpoint inhibitor, are combined with a NQO1 bioactivatable drug.
Type:
Application
Filed:
March 18, 2020
Publication date:
May 26, 2022
Applicants:
The Board of Regents of The University of Texas System, Indiana University Research and Technology Corporation, The Board of Trustees of the University of Illinois
Inventors:
Yang-Xin FU, Xiumei HUANG, David BOOTHMAN, Paul J. HERGENROTHER, Xiaoguang LI, Lingxiang JIANG
Abstract: Detection of nitroxyl (HNO), the transient one-electron reduced form of nitric oxide, is a significant challenge owing to its high reactivity with biological thiols (rate constants as high as 109M?1 s?1). Reported herein is a new thiol-based HNO-responsive trigger that can compete against reactive thiols for HNO. This process forms an N-hydroxysulfenamide intermediate which cyclizes to release a masked fluorophore leading to fluorescence enhancement. To ensure a rapid cyclization step, the disclosed design capitalizes on two established physical organic phenomena: the alpha-effect and the Thorpe-Ingold effect. Using this new trigger, NitroxylFluor was developed; a selective HNO-responsive fluorescent probe. Treatment of NitroxylFluor with an HNO donor results in a 16-fold turn-on. This probe also exhibits excellent selectivity over various reactive nitrogen, oxygen, and sulfur species and efficacy in the presence of thiols (e.g., glutathione in mM concentrations).
Type:
Grant
Filed:
November 6, 2019
Date of Patent:
May 24, 2022
Assignee:
The Board of Trustees of the University of Illinois
Abstract: The present disclosure provides compounds represented by Formula I: and pharmaceutically acceptable salts, solvates, e.g., hydrates, and prodrugs thereof, wherein X and n are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat diseases and conditions, e.g., cancer, wherein inhibition of HDAC provides a benefit.
Type:
Application
Filed:
February 1, 2022
Publication date:
May 19, 2022
Applicants:
The George Washington University, A Congressionally Chartered Not-for-Profit Corporation, The Board of Trustees of the University of Illinois
Inventors:
Alejandro VILLAGRA, Alan P. KOZIKOWSKI, Sida SHEN
Abstract: Aspects of the subject disclosure may include, for example, an apparatus comprising: a membrane having a first side and a second side, wherein the membrane has first and second pores disposed therein, a processing system; and a memory that stores executable instructions that, when executed by the processing system, facilitate performance of operations comprising: setting a first physical characteristic in a vicinity of the first pore to cause a first end of a molecule having the first end and a second end to be moved through the first pore; setting a second physical characteristic in a vicinity of the second pore to cause the second end of the molecule to be moved through the second pore; and adjusting the first physical characteristic to cause the molecule to be tightened, with a first given amount of force, between the first pore and the second pore. Additional embodiments are disclosed.
Type:
Grant
Filed:
September 6, 2017
Date of Patent:
May 17, 2022
Assignees:
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, TECHNISCHE UNIVERSITEIT DELFT
Abstract: Described herein are pyridinone-based compounds, derivatives thereof, and pharmaceutical formulations thereof. In some aspects, the pyridinone-based compounds, derivatives thereof, and/or pharmaceutical formulations thereof can be administered to a subject in need thereof. In some aspects, pyridinone-based compounds, derivatives thereof, and/or pharmaceutical formulations thereof can modulate an activity and/or a function of a BRD protein and/or BET protein.
Type:
Grant
Filed:
December 1, 2018
Date of Patent:
May 17, 2022
Assignee:
The Board of Trustees of the University of Illinois
Inventors:
Gregory R. Thatcher, Rui Xiong, Jiong Zhao, Yangfeng Li
Abstract: A segmentation method and segmentation apparatus are provided, where the segmentation method includes receiving image frames comprising a current frame and an adjacent frame to the current frame, determining a feature map to aggregate the image frames based on temporal information between the current frame and the adjacent frame, extracting a feature of a region of interest (ROI) corresponding to instances included in the current frame from the feature map, predicting a class of an object corresponding to the ROI based on the feature of the ROI, and segmenting the instances by correcting an amodal mask predicted corresponding to the class of the object based on the feature of the ROI.
Type:
Application
Filed:
November 3, 2021
Publication date:
May 12, 2022
Applicants:
The Board of Trustees of the University of Illinois (Urbana, IL), SAMSUNG ELECTRONICS CO., LTD.
Inventors:
Jihye KIM, Raymond Alexander Yeh, Alexander Gerhard Schwing, Yuan-Ting Hu