Abstract: The present invention concerns methods and compositions involving inhibitors of Pre-B Cell Colony Enhancing Factor (PBEF) for inflammatory conditions and diseases, including acute lung injury (ALI), ventilator-induced lung injury (VILI), and acute respiratory distress syndrome (ARDS). The present invention also concerns biomarkers for inflammation as well as methods for screening for PBEF inhibitors.
Type:
Grant
Filed:
July 23, 2010
Date of Patent:
August 9, 2016
Assignee:
The Board of Trustess of the University of Illinois
Abstract: A novel biosensor comprises at least one fluorophore and at least two quenchers, and is capable of selectively and specifically detecting the presence of an ion in the presence of other ions.
Type:
Grant
Filed:
May 10, 2002
Date of Patent:
May 10, 2005
Assignee:
The Board of Trustess of the University of Illinois
Abstract: A composite material, contains a polymer, a polymerizer, a corresponding catalyst for the polymerizer, and a plurality of capsules. The polymerizer is in the capsules. The composite material is self-healing.
Type:
Grant
Filed:
October 25, 2002
Date of Patent:
February 22, 2005
Assignee:
The Board of Trustess of the University of Illinois
Inventors:
Scott R. White, Nancy R. Sottos, Philippe H. Geubelle, Jeffrey S. Moore, Suresh R. Sriram, Michael R. Kessler, Eric N. Brown
Abstract: A method for producing the silicon nanoparticle of the invention is a gradual advancing electrochemical etch of bulk silicon. Separation of nanoparticles from the surface of the silicon may also be conducted. Once separated, various methods may be employed to form nanoparticles into colloids, crystals, films and other desirable forms. The particles may also be coated or doped.
Type:
Grant
Filed:
October 22, 1999
Date of Patent:
July 1, 2003
Assignee:
The Board of Trustess of the University of Illinois
Inventors:
Munir H. Nayfeh, Joel Therrien, Zain H. Yamani
Abstract: This invention is directed to methods for preventing the emergence of multidrug resistance in tumor cells during cancer chemotherapy. In particular, it relates to the use of protein kinase inhibitors to prevent the induction of expression of the multidrug resistance gene (MDR1) encoding P-glycoprotein by chemotherapeutic drugs. MDR1 expression, which results in tumor cell resistance to subsequent treatment with certain chemotherapeutic drugs, is shown herein to be induced in response to treatment with various cytotoxic agents, including such agents that are and are not substrates for P-glycoprotein-mediated efflux from cancer cells. Inhibitors of protein kinases, in particular, protein kinase C, are shown herein to suppress this cellular response. In addition, such protein kinase inhibitors are also shown herein to inhibit expression of a gene encoding a multidrug resistance-associated protein (the MRP gene).
Type:
Grant
Filed:
January 10, 1995
Date of Patent:
October 26, 1999
Assignee:
Board of trustess of the University of Illinois
Inventors:
Preet Chaudhary, Alexander A. Shtil, Igor B. Roninson