Abstract: Provided is a separatome-based peptide, polypeptide, and protein expression and purification platform based on the juxtaposition of the binding properties of host cell genomic peptides, polypeptides, and proteins with the characteristics and location of the corresponding genes on the host cell chromosome of E. coli. The separatome-based protein expression and purification platform quantitatively describes and identifies priority deletions, modifications, or inhibitions of certain gene products to increase chromatographic separation efficiency, defined as an increase in column capacity, column selectivity, or both, with emphasis on the former. Moreover, the separatome-based protein expression and purification platform provides a computerized knowledge tool that, given separatome data and a target recombinant peptide, polypeptide, or protein, intuitively suggests strategies facilitating efficient product purification.

Abstract: Disclosed are a latch circuit and method for preventing double node upsets (DNUs). A first, second, and third storage circuit, each comprising four inputs and an output, are electrically interconnected with a first and second three-input c-element circuit, each comprising three inputs and an output, and a two-input c-element circuit comprising two inputs and an output. The output of the first storage circuit is connected to a first input of the first three-input c-element circuit, a first input of the third storage circuit and a third input of the second storage circuit. The output of the second storage circuit is connected to a second input of the first three-input c-element circuit, a first input of the two-input c-element circuit, and a second input of the second three-input c-element circuit.

Abstract: Provided in some aspects are methods and compositions for preserving platelets or other cells. In some embodiments, a platelet storage media or cell storage media may comprise a low molecular weight polyethylene glycol (e.g. PEG-400) to allow for extended storage and/or refrigeration of the platelets or cells.

Abstract: An apparatus for determining cardiac performance in the patient includes a plurality of electrodes adapted to be placed in the patient and in communication with a heart chamber of the patient for measuring conductance and blood volume in the heart chamber of the patient; and a processor for determining instantaneous volume of the ventricle based on measurement of complex admittance at a plurality of frequencies to identify mechanical strength of the chamber, the processor in communication with the electrodes. A method for determining cardiac performance in a patient.

Abstract: Actuators (artificial muscles) comprising twist-spun nanofiber yarn or twist-inserted polymer fibers generate torsional actuation when powered electrically, photonically, chemically, thermally, by absorption, or by other means. These artificial muscles utilize coiled yarns/polymer fibers and can be either neat or comprising a guest. In some embodiments, the torsional fiber actuator includes a first polymer fiber (exhibiting a first polymer fiber diameter) and a torsional return spring in communication with the first polymer fiber. The first polymer fiber is configured to include a first plurality of twists in a first direction to produce a twisted polymer fiber. The first polymer fiber is further configured to include a plurality of coils in the twisted polymer fiber in a second direction each coil having a mean coil diameter.

Abstract: The invention provides compounds formula (I) and salts thereof: wherein the bond represented by ---- is a single bond or a double bond, and R1 has any of the values defined in the specification. The compounds are useful for treating conditions including Alzheimer's disease, Parkinson's disease, diabetes, cancer, and psychotic disorders such as schizophrenia.

Abstract: Engineered peptides that bind with high affinity (low equilibrium dissociation constant (Kd)) to the cell surface receptors of fibronectin (?5?1) or vitronectin (?v?3 and ?v?5 integrins) are disclosed as useful as imaging tissue. These peptides are based on a molecular scaffold into which a subsequence containing the RGD integrin-binding motif has been inserted. The subsequence (RGD mimic) comprises about 9-13 amino acids, and the RGD contained within the subsequence can be flanked by a variety of amino acids, the sequence of which was determined by sequential rounds of selection (in vitro evolution). The molecular scaffold is preferably based on a knottin, e.g., EETI (Trypsin inhibitor 2 (Trypsin inhibitor II) (EETI-II) [Ecballium elaterium (Jumping cucumber)], AgRP (Agouti-related protein), and Agatoxin IVB, which peptides have a rigidly defined three-dimensional conformation. It is demonstrated that EETI tolerates mutations in other loops and that the present peptides may be used as imaging agents.

Abstract: Systems and techniques are disclosed for flexible, secure energy management that enable control of individual devices in a customer site's energy infrastructure, which can allow optimization (e.g., by minimizing energy cost or usage) across the infrastructure. A system management component may centralize optimization and control capabilities across the energy infrastructure by determining an energy model and directing consumption, storage, and energy draw activities for the totality of the energy infrastructure devices. Systems may include modular, secure terminal devices that can be attached to or paired with the devices in an energy infrastructure in order to provide input data such as power load metrics, as well as to control the operation of the devices. A dynamic, adaptive prediction of system parameters, such as future demand, cost, generation capacity, and other metrics, may be provided. Dynamic, adaptive prediction may be performed without detailed historical usage data.

Abstract: The present invention provides a method, a kit and composition for determining MRSA and other Staphylococcus strain resistance to one or more antibiotic agents through detecting the presence of the respective antibiotic resistance gene. The methods include real-time PCR assays, and the kits and compositions include oligonucleotides used as primers and probes.

Abstract: Folded plate girders can be connected end to end to form a cambered girder, wherein a connector system including a peripheral connecting flange secures adjacent girders in series at the desired camber arc or angle.

Abstract: Provided are antimicrobial solutions comprising a glyceryl nitrate (e.g., glyeryl trinitrate) in combination with a chelator (e.g., citrate), a peroxide, a fatty acid, and/or an alcohol (e.g., ethanol). In various aspects these components may synergistically act to kill or reduce the growth of microbes, such as bacteria or fungi, present in a biofilm.

Abstract: Methods for identifying compounds that positively regulate connexin 43 hemichannels.

Abstract: A transmission system is used in a method of transmitting a camouflaged transmission of signals by generating an underlying transmission comprising a plasma transmission discharge constituting background noise having a first amplitude and generating an embedded transmission of signals within the underlying transmission.

Abstract: Provided herein are vaccine vectors including an antigenic polypeptide and an HMGB1 polypeptide present on the surface of the vaccine vector. Compositions comprising the vaccine vectors are also provided and include a pharmaceutically acceptable carrier, suitably a carrier for oral or nasal administration. Also provided are methods of enhancing immune responses, in particular antibody immune response and suitably an IgA response, by administering the vaccine vectors or compositions disclosed herein to a subject.

Abstract: A method of making silicone microspheres comprises nebulizing a silicone precursor solution comprising one or more oligomeric dimethylsiloxanes, a catalyst and a solvent into an aerosol comprising a plurality of droplets. Each droplet comprises the silicone precursor solution. The droplets are entrained in a gas which is flowed through a reaction zone comprising light energy and/or heat energy. Upon exposure of the droplets to the light energy and/or the heat energy, the solvent evaporates and the one or more oligomeric dimethylsiloxanes are polymerized. Thus, silicone microspheres are formed from the droplets of the aerosol.

Abstract: The invention relates to antibodies, antibody fragments and binding agents that specifically recognize oligomeric tau but do not bind to monomeric tau, fibrillar tau or non-disease associated forms of tau.

Abstract: Disclosed herein are compounds and compositions thereof which find use in increasing stability of proteins particularly proteins that tend to misfold and form aggregates. Also provided herein are methods for using these compounds and compositions for increasing stability of proteins and thereby decreasing aggregate formation by these proteins. Also disclosed herein are heterobifunctional compounds that include a TTR binding compound connected to a targeting moiety via a linker, for use in disrupting PPIs of a target protein.

Abstract: In an embodiment of the present invention, a GraphSLAM-like algorithm for signal strength SLAM is presented. This algorithm as an embodiment of the present invention shares many of the benefits of Gaussian processes yet is viable for a broader range of environments since it makes no signature uniqueness assumptions. It is also more tractable to larger map sizes, requiring O(N2) operations per iteration. In the present disclosure, an algorithm according to an embodiment of the present invention is compared to a laser-SLAM ground truth, showing that it produces excellent results in practice.

Abstract: A soybean cultivar designated UA 5715GT is disclosed. The invention relates to the seeds of soybean cultivar UA 5715GT, to the plants of soybean cultivar UA 5715GT, to the plant parts of soybean cultivar UA 5715GT, and to methods for producing progeny of soybean cultivar UA 5715GT. The invention also relates to methods for producing a soybean plant containing in its genetic material one or more transgenes and to the transgenic soybean plants and plant parts produced by those methods. The invention also relates to soybean cultivars or breeding cultivars, and plant parts derived from soybean cultivar UA 5715GT. The invention also relates to methods for producing other soybean cultivars, lines, or plant parts derived from soybean cultivar UA 5715GT, and to the soybean plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid soybean seeds, plants, and plant parts produced by crossing cultivar UA 5715GT with another soybean cultivar.

Abstract: Described here is a device comprising a microfluidic chip and an acoustic transducer external to the microfluidic chip, wherein the microfluidic chip comprises a channel in communication with a microwell having a volume less than one microliter, and wherein the acoustic transducer is coupled to the microfluidic chip via a coupling medium.