Abstract: An autophagy-inducing compound comprises an autophagy-inducing peptide comprising beclin-1 residues 269-283 and a heterologous moiety that promotes therapeutic stability or delivery of the compound. The compound may be used to induce autophagy and in assays with beclin-1 binding partners.
Type:
Grant
Filed:
November 8, 2013
Date of Patent:
May 13, 2014
Assignee:
Board of Regents, The University of Texas System
Inventors:
Beth C. Levine, Sanae Shoji-Kawata, Olivier Lichtarge, Angela D. Wilkins
Abstract: The present invention relates to the selective modulation of pre-mRNA splicing, in particular, for that involving alternative splicing in disease-related proteins such as those involved in Duschenne's Muscular Dystropy and Spinal Muscular Atrophy.
Type:
Application
Filed:
March 23, 2012
Publication date:
May 8, 2014
Applicant:
The Board of Regents of the University of Texas System
Abstract: The present invention relates to the medical use of nitrites, such as inorganic nitrites, or any pharmaceutically acceptable salts, solvates, compositions, or prodrugs thereof, in the treatment of conditions that benefit from increased cerebral vascular flow. The pharmaceutical compositions used in these methods, which can be formulated for oral administration, can provide immediate release or extended release of the nitrite ion (NO2?).
Type:
Application
Filed:
March 30, 2012
Publication date:
May 8, 2014
Applicants:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, Thera Vasc Inc.
Inventors:
Anthony Giordano, Frank Greenway, Jeffrey Keller, Christpher Kevil
Abstract: A fiber-facet AFM probe enabling high-resolution, high sensitivity measurement of a sample surface is presented. AFM probes in accordance with the present invention include an optically resonant cavity that is defined by two mirrors, at least one of which is a photonic-crystal mirror. One of the mirrors is movable and is mechanically coupled with an AFM tip such that a force imparted on the tip by an interaction with the sample surface induces a change in the cavity length of the optically resonant cavity and, therefore, its reflectivity.
Type:
Application
Filed:
March 15, 2013
Publication date:
May 8, 2014
Applicant:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Olav Solgaard, Antonio A. Gellineau, Xuan Wu, Jo Wonuk, Karthik Vijayraghavan
Abstract: A high-bandwidth AFM probe having a diffraction grating characterized by a diffraction characteristic that monotonically changes along the length of the diffraction grating is disclosed. AFM probes in accordance with the present invention are capable of high-sensitivity performance over a broad range of operating conditions, such as operating wavelength and measurement media. A method for estimating at least one physical property of a surface based on high-frequency signal components in the output signal from a high-bandwidth AFM probe is also disclosed. The method enables determination of tip-surface interaction forces based on the relationship between a first motion of the base of the AFM probe and a second motion of the tip of the AFM probe.
Type:
Application
Filed:
March 14, 2013
Publication date:
May 8, 2014
Applicant:
The Board of Trustees of the Leland Stanford Junior University
Inventor:
The Board of Trustees of the Leland Stanford Junior University
Abstract: Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a peripheral neuropathy, a neurological disease, traumatic brain injury, stroke, hypertension, malaria, an autoimmune disease, autism, autism spectrum disorders, and inflammation, also are disclosed.
Type:
Application
Filed:
January 31, 2012
Publication date:
May 8, 2014
Applicant:
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
Inventors:
Alan Kozikowski, Jay H. Kalin, Kyle V. Butier, Joel Bergman, Wayne W. Hancock
Abstract: A battery pack having a plurality of battery pack modules, wherein each battery pack module includes a battery cell and a power converter. The power converters of the plurality of battery pack modules are connected in series to form a string of N battery pack modules such that the voltage across the N battery pack modules defines the output voltage of the battery pack. A controller regulates the output voltage of each battery cell or module power converter and the output voltage of the battery pack by independently controlling each battery cell module in accordance with variables such as state-of-charge (SOC), state-of-health (SOH) and temperature, capacity, and temperature of each individual battery cell module. The power converter may be used to measure impedance of the battery pack by adding a sinusoidal perturbation signal to a reference voltage of the cell battery pack module.
Type:
Application
Filed:
October 30, 2013
Publication date:
May 8, 2014
Applicant:
Board of Trustees of The University of Alabama
Abstract: A multi-lead multi-electrode system and method of manufacturing the multi-lead multi-electrode system includes a multi-electrode lead that may be used to deploy multiple separable electrodes to different spaced apart contact sites, such as nerve or muscle tissues, for example, that are spatially distributed over a large area.
Type:
Application
Filed:
November 6, 2013
Publication date:
May 8, 2014
Applicant:
THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES
Inventors:
Anil K. Thota, Ranu Jung, Sathyakumar S. Kuntaegowdanahalli
Abstract: Methods and apparatuses, including computer program products, are provided for determining the null-space for a channel between a transmitter and an unintended receiver. In one aspect there is provided a method. The method may include transmitting, by a secondary transmitter, a plurality of learning signals, determining, for each of the plurality of learning signals, a value representative of an interference caused by the transmitting to an unintended receiver, determining, based on the determined values, a null-space for a channel between the secondary transmitter and the unintended receiver and transmitting, by the secondary transmitter, a signal in accordance with the determined null-space.
Type:
Application
Filed:
April 26, 2013
Publication date:
May 8, 2014
Applicant:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Andrea Goldsmith, Yair Noam, Alexandros Manolakos, Konstantinos Dimou
Abstract: The present invention includes compound compositions and methods of making compounds that include an oligo-benzamide compound having at least two optionally substituted benzamides.
Type:
Application
Filed:
October 28, 2013
Publication date:
May 8, 2014
Applicant:
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Abstract: Embodiments of compounds for selectively detecting an analyte are disclosed, along with methods and kits for detecting analytes with the compounds. The compounds are bridged viologen conjugates including at least one fluorophore according to the general structure At least one of R1/R2, R2/R3, R3/R4, R5/R6, R6/R7, and/or R7/R8 together form a substituted or unsubstituted cycloalkyl or aryl.
Type:
Application
Filed:
June 29, 2012
Publication date:
May 8, 2014
Applicant:
The Oregon State Board of Higher Education on Behalf of Portland State University
Inventors:
Robert Michael Strongin, Martha Sibrian-Vazquez, Jorge Omar Escobedo-Cordova, Mark Allen Lowry
Abstract: The present invention provides methods for synthetic antibodies, methods for making synthetic antibodies, methods for identifying ligands, and related methods and reagents.
Type:
Application
Filed:
November 5, 2013
Publication date:
May 8, 2014
Applicant:
Arizona Board of Regents, a body corporate of the State of Arizona, acting for and on behaif of Ariz
Inventors:
Stephen A Johnston, Neal Woodbury, Christopher W. Diehnelt, Paul Belcher, Nidhi Gupta, Zhang-Gong Zhoa, Matthew Greving, Jack Emery
Abstract: A method for treating and/or diagnosing pain and the source or type of pain, shock, and/or inflammatory conditions in a subject. A method of using a therapeutically effective amount of a DNA or RNA aptamer that shows high affinity for OLAMs to at least partially treat pain, shock, and/or inflammatory conditions in a subject. The DNA or RNA aptamer that shows high affinity for OLAMs may be coupled to a plasma protein binding compound or a pharmacologically active agent. A method of treating and or diagnosing pain, shock, and/or inflammatory conditions in a subject may include inactivating or preventing at least one linoleic acid metabolite to treat certain conditions (e.g., pain, shock, and/or inflammation) using a DNA or RNA aptamer that shows high affinity for OLAMs.
Type:
Application
Filed:
September 17, 2013
Publication date:
May 8, 2014
Applicant:
Board of Regents of the University of Texas System
Inventors:
Kenneth Michael Hargreaves, John Gordon Bruno
Abstract: Methods and composition for denoising digital camera images are provided herein. The method is based on directly measuring the local statistical structure of natural images in a large training set that has been corrupted with noise mimicking digital camera noise. The measured statistics are conditional means of the ground truth pixel value given a local context of input pixels. Each conditional mean is the Bayes optimal (minimum mean squared error) estimate given the specific local context. The conditional means are measured and applied recursively (e.g., the second conditional mean is measured after denoising with the first conditional mean). Each local context vector consists of only three variables, and hence the conditional means can be measured directly without prior assumptions about the underlying probability distributions, and they can be stored in fixed lookup tables.
Type:
Application
Filed:
August 12, 2013
Publication date:
May 8, 2014
Applicant:
Board of Regents, the University of Texas System
Abstract: A modular multi-channel inline connector system that connects an implanted electrode within a body of an organism, such as the human body, with a device located external to or implanted within the body. The modular multi-channel inline system comprises of a first lead operatively connected to the implanted electrode and to a first connector portion. A second lead is operatively connected to a second connector portion and operatively connected to the device. One of the first and second connector portions comprises a male connector and the other of the first and second connector portions comprises a female connector. The first and second connector portions are arranged to connect with each other and to be operatively located embedded within the body.
Type:
Application
Filed:
November 6, 2013
Publication date:
May 8, 2014
Applicant:
THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES
Inventors:
Sathyakumar S. Kuntaegowdanahalli, James J. Abbas, Ranu Jung, Kenneth Horch
Abstract: An investment instrument based on a range of index values is disclosed that allows investors to take risk positions relative to the size, or length, of the range. The investment instrument has a monetary value that increases as the index value increases within a low range interval of the range, decreases as the index value increases within a high range interval of the range, and is fixed or capped if the index value falls within a middle range interval of the range. Typically, one settlement amount will be zero and the other will be an amount greater than the investment instrument price.
Type:
Grant
Filed:
March 16, 2012
Date of Patent:
May 6, 2014
Assignee:
Chicago Board Options Exchange, Incorporated
Inventors:
Marty O'Connell, John Hiatt, Jr., William Speth
Abstract: Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for delivering a light-activated molecule comprising a nucleic acid sequence that codes for light-activated molecule. The light-activated molecule includes a modification to a location near the all-trans retinal Schiff base, e.g., to extends the duration time of the open state. Other aspects and embodiments are directed to systems, methods, kits, compositions of matter and molecules for ion channels or pumps or for controlling currents in a cell (e.g., in in vivo and in vitro environments).
Type:
Grant
Filed:
November 13, 2009
Date of Patent:
May 6, 2014
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Karl Deisseroth, Ofer Yizhar, Lisa Gunaydin, Peter Hegemann, Andre Berndt