Patents Assigned to Board to Trustees of the Leland Stanford Junior University
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Publication number: 20240175088Abstract: Processes and materials to detect cancer from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences derived from a neoplasm. Detection of somatic variants occurring in phase can indicate the presence of cancer in a diagnostic scan and a clinical intervention can be performed.Type: ApplicationFiled: February 7, 2024Publication date: May 30, 2024Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: David M. Kurtz, Maximilian Diehn, Arash Ash Alizadeh
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Publication number: 20240173355Abstract: The present disclosure provides methods and compositions for treating RAG2 deficiencies in subjects, comprising genetically modifying cells from the subjects ex vivo by integrating a functional, codon-optimized RAG 2 cDNA at the endogenous RAG2 locus.Type: ApplicationFiled: April 5, 2022Publication date: May 30, 2024Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Mara Pavel-Dinu, Matthew H. Porteus
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Publication number: 20240175752Abstract: Systems and methods for compact and low-cost vibrational spectroscopy platforms are described. Many embodiments implement deep learning processes to identify the relevant optical spectral features for the identification of an element from a set of elements. Several embodiments provide that resolution reduction and feature selection render efficient data analysis processes. By reducing the spectral data from the full wide-band high-resolution spectrum to a subset of spectral bands, a number of embodiments provide compact and low-cost hardware incorporation in spectroscopic platforms for element identification functions.Type: ApplicationFiled: March 30, 2022Publication date: May 30, 2024Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Jennifer A. Dionne, Ahmed Shuaibi, Amr A. E. Saleh
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Publication number: 20240173370Abstract: Provided herein are hydrogels that include a plurality of bacteriophages located within and covalently bonded to the hydrogel interior. The hydrogel is engineered to facilitate a controlled sustained release of the connected bacteriophages, e.g., to or within the body of a patient suffering from a bacterial infection. Also provided are methods for forming the provided hydrogels, and for using the hydrogels to treat a patient suffering from a bacterial infection.Type: ApplicationFiled: March 25, 2022Publication date: May 30, 2024Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Ovijit CHAUDHURI, Paul L. BOLLYKY, Robert MANASHEROB, Yung-Hao LIN, Derek AMANATULLAH
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Patent number: 11994472Abstract: Improved stimulated Raman spectroscopy is provided by replacing the Stokes (or anti-Stokes) optical source with a localized electromagnetic emitter that is excited with a non-electromagnetic excitation. Such a localized emitter can be an efficient Stokes (or anti-Stokes) source for stimulated Raman spectroscopy, and can also provide deep sub-wavelength spatial resolution. In a preferred embodiment, an electron beam from an electron microscope is used to excite the localized emitter. This provides combined Raman imaging and electron microscopy that has the two imaging modalities inherently registered with each other.Type: GrantFiled: July 24, 2020Date of Patent: May 28, 2024Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Jennifer A. Dionne, Amr Ahmed Essawi Saleh, Daniel K. Angell
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Patent number: 11996285Abstract: Silicon carbide on insulator is provided by bonding bulk silicon carbide to a substrate with an oxide-oxide fusion bond, followed by thinning the bulk silicon carbide as needed. A doping-selective etch for silicon carbide is used to improve thickness uniformity of the silicon carbide layer(s).Type: GrantFiled: September 3, 2021Date of Patent: May 28, 2024Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Daniil M. Lukin, Jelena Vuckovic
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Patent number: 11992630Abstract: Devices and methods are provided to facilitate self-catheterization of a urethra. In an exemplary embodiment, the device includes an elongate anchor member comprising a proximal end and a rounded distal end to facilitate insertion into a user's vagina, a bridge extending laterally from an intermediate location of the anchor member, a guide on the bridge spaced apart from the anchor member such that the guide is aligned with the user's urethra, the guide including a passage therethrough sized to receive a urinary catheter therethrough, and a handle on the proximal end of the anchor member to facilitate manipulation by the user and consistent, accurate alignment of the guide.Type: GrantFiled: August 24, 2020Date of Patent: May 28, 2024Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Craig Comiter, Gabe Ho, Maria Iglesias, Isaac Justice, Amanda Urke
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Patent number: 11992298Abstract: Systems and methods for predicting and treating relapses for neurological conditions in accordance with embodiments of the invention are illustrated. One embodiment includes a method for predicting and treating a clinical neurological condition relapse. The method includes steps for selecting a threshold heart rate variability value for a patient suffering from a clinical neurological condition, monitoring, using a cardiac monitor, the heart rate variability of the patient over time, providing an indicator that a relapse is imminent when the heart rate variability of the patient falls below the threshold heart rate variability value, and treating the patient using a transcranial magnetic stimulation device by applying an accelerated theta burst stimulation protocol where the transcranial magnetic stimulation target is the left prefrontal dorsolateral cortex.Type: GrantFiled: October 26, 2023Date of Patent: May 28, 2024Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Nolan Williams, Keith Sudheimer
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Patent number: 11993645Abstract: R-spondin (RSPO) surrogate compositions and methods for their use are provided. RSPO surrogates of the invention comprise (i) a specific binding domain for Ring Finger Protein 43 (RNF43) or Zinc and Ring Finger Protein 3 (ZNRF3) and (ii) a cell targeting domain More specifically, wherein the specific binding domain for RNF43 or ZNRF3 is an antibody fragment, and wherein the cell targeting domain is a cytokine.Type: GrantFiled: January 11, 2018Date of Patent: May 28, 2024Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Vincent Christopher Luca, Kenan Christopher Garcia
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Patent number: 11993639Abstract: Variant IL-13 polypeptides are provided, which are engineered to have one or more of the following properties: (a) altered affinity for IL-13R?2, relative to the native human IL-13 protein; (b) altered affinity for IL-13R?1 relative to the native human IL-13 protein; (c) a disruption in the binding site for IL-4R? relative to the native human IL-13 protein.Type: GrantFiled: July 29, 2021Date of Patent: May 28, 2024Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Kenan Christopher Garcia, Ignacio Moraga Gonzalez
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Patent number: 11986267Abstract: Systems, methods and devices are implemented for microscope imaging solutions. One embodiment of the present disclosure is directed toward an epifluorescence microscope. The microscope includes an image capture circuit including an array of optical sensor. An optical arrangement is configured to direct excitation light of less than about 1 mW to a target object in a field of view of that is at least 0.5 mm2 and to direct epi-fluorescence emission caused by the excitation light to the array of optical sensors. The optical arrangement and array of optical sensors are each sufficiently close to the target object to provide at least 2.5 ?m resolution for an image of the field of view.Type: GrantFiled: August 26, 2022Date of Patent: May 21, 2024Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Kunal Ghosh, Laurie D. Burns, Abbas El Gamal, Mark J. Schnitzer, Eric Cocker, Tatt Wei Ho
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Patent number: 11988716Abstract: A battery health monitoring system that utilizes adaptive cathode and adaptive anode observers to estimate the ion concentrations at the respective cathode and anode of a battery. Subsequently, the estimated ion concentrations can be used in a battery model to estimate the state of heath and state of charge of the battery. Additionally, the model and ion concentrations can be updated real time as aging components of the battery are evaluated in the output data from the battery.Type: GrantFiled: March 16, 2020Date of Patent: May 21, 2024Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Anirudh Allam, Simona Onori
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Patent number: 11989641Abstract: A brain machine interface (BMI) to control a device is provided. The BMI has a neural decoder, which is a neural to kinematic mapping function with neural signals as input to the neural decoder and kinematics to control the device as output of the neural decoder. The neural decoder is based on a continuous-time multiplicative recurrent neural network, which has been trained as a neural to kinematic mapping function. An advantage of the invention is the robustness of the decoder to perturbations in the neural data; its performance degrades less—or not at all in some circumstances—in comparison to the current state decoders. These perturbations make the current use of BMI in a clinical setting extremely challenging. This invention helps to ameliorate this problem. The robustness of the neural decoder does not come at the cost of some performance, in fact an improvement in performance is observed.Type: GrantFiled: October 3, 2022Date of Patent: May 21, 2024Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: David Sussillo, Jonathan C. Kao, Sergey Stavisky, Krishna V. Shenoy
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Patent number: 11980613Abstract: This disclosure provides methods of using BAF complex modulating compounds as inhibitors of BAF-mediated transcription in target cells. The BAF complex modulating compounds include 12-membered macrolactam compounds that can target a BAF-specific subunit (e.g., ARID1A) to prevent nucleosomal positioning, relieving transcriptional repression of HIV-1. The subject methods can provide for reversal of latency of HIV-1 in cells in vitro or in vivo. Use of the macrolactam BAF complex modulating compounds represent a method of HIV latency reversal with a unique mechanism of action, which can be optionally combined with other Latency Reversal Agents to improve reservoir targeting. The subject methods can be utilized in conjunction with any convenient methods of treating HIV or HIV latency, including methods related to immune system activation, antiretroviral therapies and/or anti-HIV agents.Type: GrantFiled: July 11, 2019Date of Patent: May 14, 2024Assignees: The Board of Trustees of the Leland Stanford Junior University, Purdue Research Foundation, Erasmus University Medical Center RotterdamInventors: Emily C. Dykhuizen, Gerald R. Crabtree, Tokameh Mahmoudi
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Publication number: 20240148858Abstract: There are provided herein, inter alia, complexes, compositions and methods for a vaccine for COVID-19. The cell-penetrating complexes provided herein may include a nucleic acid non-covalently bound to a cationic amphipathic polymer, the cationic amphipathic polymer including a pH-sensitive immolation domain. The cell-penetrating complexes provided herein are, inter alia, useful in vaccines, wherein the vaccine includes a ribonucleic acid including a sequence encoding a viral protein, a nucleic acid adjuvant and a cationic amphipathic polymer provided herein including embodiments thereof.Type: ApplicationFiled: July 26, 2021Publication date: May 9, 2024Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Ronald Levy, Ole Audun Werner Haabeth, Adrienne Sallets, Timothy R. Blake, Paul Wender, Robert M. Waymouth, Debra Czerwinski, Idit Sagiv-Barfi, Julian Johannes Lohmeyer
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Publication number: 20240153107Abstract: Systems and methods for performing three-dimensional multi-object tracking are disclosed herein. In one example, a method includes the steps of determining a residual based on augmented current frame detection bounding boxes, augmented previous frame detection bounding boxes, augmented current frame shape descriptors, and augmented previous frame shape descriptors and predicting an affinity matrix using the residual. The residual indicates a spatiotemporal and shape similarity between current detections in a current frame point cloud data and previous detections in a previous frame point cloud data. The affinity matrix indicates associations between the previous detections and the current detections, as well as the augmented anchors.Type: ApplicationFiled: May 10, 2023Publication date: May 9, 2024Applicants: Toyota Research Institute, Inc., The Board of Trustees of the Leland Stanford Junior University, Toyota Jidosha Kabushiki KaishaInventors: Jie Li, Rares A. Ambrus, Taraneh Sadjadpour, Christin Jeannette Bohg
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Publication number: 20240149267Abstract: Systems and methods in accordance with various embodiments of the invention are capable of rapid analysis and classification of cellular samples based on cytomorphological properties. In several embodiments, cells suspended in a fluid medium are passed through a microfluidic channel, where they are focused to a single stream line and imaged continuously. In a number of embodiments, the microfluidic channel establishes flow that enables individual cells to each be imaged at multiple angles in a short amount of time. A pattern recognition system can analyze the data captured from high-speed images of cells flowing through this system and classify target cells. In this way, the automated platform creates new possibilities for a wide range of research and clinical applications such as (but not limited to) point of care services.Type: ApplicationFiled: August 11, 2023Publication date: May 9, 2024Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Mahdokht Masaeli, Euan A. Ashley
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Publication number: 20240153101Abstract: A method for scene synthesis from human motion is described. The method includes computing three-dimensional (3D) human pose trajectories of human motion in a scene. The method also includes generating contact labels of unseen objects in the scene based on the computing of the 3D human pose trajectories. The method further includes estimating contact points between human body vertices of the 3D human pose trajectories and the contact labels of the unseen objects that are in contact with the human body vertices. The method also includes predicting object placements of the unseen objects in the scene based on the estimated contact points.Type: ApplicationFiled: October 25, 2023Publication date: May 9, 2024Applicants: TOYOTA RESEARCH INSTITUTE, INC., THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITYInventors: Sifan YE, Yixing WANG, Jiaman LI, Dennis PARK, C. Karen LIU, Huazhe XU, Jiajun WU
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Patent number: 11977312Abstract: Provided is an optical modulator including a substrate, and a plurality of meta units provided on the substrate and spaced apart from each other, wherein at least one of the plurality of meta units includes a metal layer provided on the substrate, a dielectric layer provided an upper surface and side surfaces of the metal layer, and an antenna provided on an upper surface of the dielectric layer, the antenna including phase change material, wherein a refractive index of the phase change material changes based on a voltage applied to the metal layer to modulate incident light.Type: GrantFiled: August 4, 2021Date of Patent: May 7, 2024Assignees: SAMSUNG ELECTRONICS CO., LTD., The Board of Trustees of the Leland Stanford Junior UniversityInventors: Junghyun Park, Mark L. Brongersma, Yifei Wang
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Patent number: 11974981Abstract: Methods and compositions are provided for treating endometriosis in an individual, and the pain associated with endometriosis. Aspects of the methods include administering to the individual an agent that promotes ALDH activity.Type: GrantFiled: February 25, 2022Date of Patent: May 7, 2024Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Eric Gross, Daria Mochly-Rosen, Stacy Lynn McAllister