Abstract: The following discloses mammalian cells lines that stably express functional nematode acetylcholine receptor subunits. The resulting expression of functional ion channels has been made possible by the stable co-expression of the chaperone protein, RIC3. These cell lines are extremely useful for the high throughput screening (HTS) of compounds, to identify new candidate parasiticidal, including nematocidal, active ingredients.
Type:
Grant
Filed:
September 9, 2015
Date of Patent:
July 9, 2019
Assignees:
BOEHRINGER INGELHEIM ANIMAL HEALTH INC., SANOFI
Inventors:
Lance Hammerland, Brenda Bondesen, Jean-Marie Chambard, Thierry Vermat, Werner Dittrich, Michel Partiseti, Qing Zhou-Liu, Cathy Cojean, Rachid Boukaiba, Eric Tagat
Abstract: The invention includes a vaccine and sera for treatment of Mystery Swine Disease (MSD), a method for producing the vaccine, methods for diagnosis of MSD, a viral agent that will mimic “mystery swine disease” and antibodies to the viral agent useful in diagnosis and treatment of MSD. The serum contains mammalian antibodies which are effective in treating MSD.
Type:
Application
Filed:
October 28, 2002
Publication date:
September 11, 2003
Applicant:
Boehringer Ingelheim Animal Health, Inc.
Inventors:
James E. Collins, David A. Benfield, Danny W. Chladek, Louis L. Harris, David E. Gorcyca
Abstract: The invention includes a vaccine and sera for treatment of Mystery Swine Disease (MSD), a method for producing the vaccine, methods for diagnosis of MSD, a viral agent that will mimic “mystery swine disease” and antibodies to the viral agent useful in diagnosis and treatment of MSD. The serum contains mammalian antibodies which are effective in treating MSD.
Type:
Application
Filed:
December 18, 2000
Publication date:
September 13, 2001
Applicant:
Boehringer Ingelheim Animal Health, Inc.
Inventors:
James E. Collins, David A. Benfield, Danny W. Chladek
Abstract: The invention includes a vaccine and sera for treatment of Mystery Swine Disease (MSD), a method for producing the vaccine, methods for diagnosis of MSD, a viral agent that will mimic "mystery swine disease" and antibodies to the viral agent useful in diagnosis and treatment of MSD. The serum contains mammalian antibodies which are effective in treating MSD.
Type:
Grant
Filed:
September 30, 1994
Date of Patent:
December 8, 1998
Assignees:
Boehringer Ingelheim Animal Health, Inc., South Dakota State University, Regents of University of Minnesota
Inventors:
James E. Collins, David A. Benfield, Danny W. Chladek, Louis L. Harris, David E. Gorcyca
Abstract: The invention includes a vaccine and sera for treatment of Mystery Swine Disease (MSD), a method for producing the vaccine, methods for diagnosis of MSD, a viral agent that will mimic "mystery swine disease" and antibodies to the viral agent useful in diagnosis and treatment of MSD. The serum contains mammalian antibodies which are effective in treating MSD.
Type:
Grant
Filed:
July 9, 1996
Date of Patent:
November 24, 1998
Assignee:
Boehringer Ingelheim Animal Health, Inc.
Inventors:
Danny W. Chladek, Louis L. Harris, David E. Gorcyca
Abstract: An improved bio-reactor with spiral or coil-shaped filling bodies is disclosed, the improvement comprising use of a gas diffusion tube through which air, oxygen or other gases can be bubbled through the fermentation medium.
Type:
Grant
Filed:
February 24, 1995
Date of Patent:
September 30, 1997
Assignee:
Boehringer Ingelheim Animal Health, Inc.
Abstract: A viral agent that will mimic "mystery swine" disease has been isolated and described, together with a method of growing the viral agent in vitro, and a method of attenuating the virus for vaccine preparation.
Type:
Grant
Filed:
March 7, 1994
Date of Patent:
December 19, 1995
Assignee:
Boehringer Ingelheim Animal Health, Inc.
Inventors:
Danny W. Chladek, David E. Gorcyca, Louis L. Harris
Abstract: Novel aqueous oxytetracycline compositions comprising oxytetracycline, polyethylene glycol with a mean molecular weight of 400, and magnesium oxide. These compositions have good clarity and low viscosity.
Type:
Grant
Filed:
December 12, 1989
Date of Patent:
December 24, 1991
Assignee:
Boehringer Ingelheim Animal Health, Inc.
Inventors:
Jacob A. Zupan, Deborah L. Steinbrenner