Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl or phenyl,R.sub.2 is hydrogen, chlorine or methoxy,R.sub.3 is hydrogen or methoxy,R.sub.2 and R.sub.3, together with each other, are methylenedioxy or ethylenedioxy,R.sub.4 and R.sub.5 are each hydrogen or lower alkyl,R.sub.6 is hydrogen or lower alkoxy.R.sub.7 is lower alkoxy,R.sub.6 and R.sub.7, together with each other, are methylenedioxy or ethylenedioxy, andn is 2 or 3,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful for slowing the heart rate.

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is methyl, ethyl or propyl,R.sub.2 is hydrogen, methyl or ethyl,R.sub.3 is hydrogen or methyl, andR.sub.4 is hydrogen, alkyl of 1 to 4 carbon atoms or alkanoyl of 2 to 5 carbon atoms,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful as analgesics.

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, acetyl, alkyl of 1 to 3 carbon atoms or phenyl, and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as CNS-depressants, sedatives and tranquilizers.

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, halogen or methyl, andR.sub.2 is hydrogen, halogen, methyl or methoxy, and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as neuroleptics.

Abstract: Compounds of the formula ##STR1## wherein A is --CH.dbd.CH--, --CH.dbd.N-- or --S--,R.sub.1 is hydrogen, lower alkyl, lower alkoxy, amino, acetylamino, cyano, tetrazol-5-yl, --COR.sub.3 or a fused benzene ring,Where R.sub.3 is lower alkoxy, amino, hydroxyamino, tetrazol-5-yl-amino or, when R.sub.2 is other than hydrogen, also hydroxyl, andR.sub.2 is cyano, tetrazol-5-yl, --COR.sub.4 or, when R.sub.1 is cyano, tetrazol-5-yl or --COR.sub.3, also hydrogen, lower alkyl, lower alkoxy, amino, acetylamino or a fused benzene ring,Where R.sub.4 is lower alkoxy, amino, hydroxyl, hydroxyamino or tetrazol-5-yl-amino;Non-toxic, pharmacologically acceptable acid addition salts thereof; and, when R.sub.3 and/or R.sub.4 are hydroxyl, non-toxic, pharmacologically acceptable salts thereof formed with an inorganic or organic base. The compounds as well as their salts are useful primarily as antiallergics.

Abstract: An improved manually actuated liquid-atomizing pump assembly for non-pressurized pharmaceutical atomizers comprising a pump actuator unit and a pump unit, which causes a spray of substantially the same particle size spectrum to be discharged from the atomizer nozzle with each actuation of the pump; the improvement resides in a resilient mechanical resistance interposed between the manual pump actuator and the pump, where the resilient resistance requires a very definite amount of force to be overcome.

Abstract: Pharmaceutical dosage unit compositions containing as an active ingredient a 1-aryloxy-2-hydroxy-3-alkynylamino-propane selected from the group consisting of racemic or optically active compounds of the formula ##STR1## wherein R.sub.1 is a member selected from the group consisting of hydrogen; halogen; nitro; alkyl having from 1 to 5 carbon atoms; alkoxy having from 1 to 4 carbon atoms; alkenyl having from 2 to 5 carbon atoms; alkynyl having from 2 to 5 carbon atoms; alkylamino having from 1 to 5 carbon atoms; dialkylamino having from 1 to 5 carbon atoms in each alkyl; alkoxyalkyl having from 2 to 6 carbon atoms; alkylaminoalkyl having from 2 to 6 carbon atoms; dialkylaminoalkyl having from 3 to 12 carbon atoms; --(CH.sub.2).sub.x -NH.sub.2 or --(CH.sub.2).sub.x -OH, where x is an integer from 0 to 3; alkynyloxy having from 3 to 6 carbon atoms; alkenyloxy having from 3 to 6 carbon atoms; --CO-R.sub.9, where R.sub.

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2, which may be identical to or different from each other, are each hydrogen, chlorine, bromine or alkyl of 1 to 3 carbon atoms,R.sub.3 is hydrogen, furfuryl, hydroxyethyl, .beta.-hydroxy-phenethyl, monochlorophenyl-ethyl, dichlorophenyl-ethyl, N-ethyl-piperidyl or --A--NR.sub.6 R.sub.7,whereA is alkylene of 1 to 5 carbon atoms, andR.sub.6 and R.sub.7 are alkyl of 1 to 2 carbon atoms or, together with each other and the nitrogen atom to which they are attached, form a heterocycle selected from the group consisting of pyrrolidino, morpholino, piperazino or N'-dimethylphenyl-piperazino,R.sub.4 is hydrogen or, together with R.sub.3 and the nitrogen to which they are attached, forms a heterocycle selected from the group consisting of piperidino, morpholino, dimethyl-morpholino or N'-methyl-piperazino,R.sub.5 is hydrogen, alkyl of 1 to 3 carbon atoms, hydroxy-ethyl, diethylamino-ethyl or furfuryl,Provided, however, that R.sub.1 and R.sub.

Abstract: Compounds of the formula ##STR1## wherein X is chlorine or bromine;R.sub.1 is hydrogen, chlorine or bromine;R.sub.2 is isopropyl; tert.butyl; tert.pentyl; mono-, di- or tri-hydroxy-substituted branched alkyl of 3 to 5 carbon atoms; cyclohexyl; or hydroxycyclohexyl; andR.sub.3 is alkyl of 1 to 4 carbon atoms or, when R.sub.2 is other than cyclohexyl, also hydrogen;And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as secretolytics, antitussives, anti-ulcerogenics and stimulants for the production of the surfactant or anti-atelectasis factor of the alveoli.

Abstract: A batch process for forming a granulate of predetermined granule size distribution from a powdered solid substance or, a mixture of powdered solid substances, which comprises the steps of (a) blowing hot air upwardly through a batch of said mixture of powdered substances to form a fluidized bed having a lower portion and an upper portion, (b) spraying into the upper portion of said fluidized bed a hot bonding liquid at a rate sufficient to cause the particles of the powdered substances to coalesce and initiate a buildup of granules, (c) simultaneously breaking down the built-up granules in the lower portion of the fluidized bed by impact with rigid blades moving at high speed to establish an equilibrium between build-up and break-down of granules, the granule build-up rate slightly exceeding the break-down rate, and (d) recovering the granulate when the desired granule size distribution has been achieved.

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2, which may be identical to or different from each other, are each hydrogen, chlorine, bromine or alkyl of 1 to 3 carbon atoms,A is alkylene of 1 to 5 carbon atoms, andR.sub.6 and R.sub.7, together with each other and the nitrogen atom to which they are attached, form a heterocycle selected from the group consisting of morpholino, piperazino or N'-dimethylphenyl-piperazino, andR.sub.5 is hydrogen, alkyl of 1 to 3 carbon atoms, hydroxyethyl, diethylamino-ethyl or furfuryl,Provided, however, that R.sub.1 and R.sub.2 are other than both hydrogen or both alkyl at the same time, and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful as hypotensives, platelet aggregation inhibitors and antiarrhythmics.

Abstract: Pharmaceutical compositions containing as an active ingredient compounds of the formula ##STR1## wherein R is hydrogen or methyl, or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as morphine-antagonists and analgesics.

Abstract: Compounds of the formula ##STR1## wherein R is straight or branched alkyl of 1 to 4 carbon atoms, and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as sedatives and tranquilizers.

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or halogen,R.sub.2 is hydroxyl, alkoxy of 1 to 6 carbon atoms, aralkoxy of 7 to 10 carbon atoms, amino, (alkyl of 1 to 3 carbon atoms)-amino, piperidino or morpholino, andn is 0, 1 or 2,Diastereoisomers thereof and, when R.sub.2 is hydroxyl, non-toxic, pharmacologically acceptable salts thereof formed with an inorganic or organic base; the compounds, their diastereoisomers and the salts are useful as antithrombotics, anti-hypercholesteremics and anti-hyperglyceridemics.

Abstract: A compound of the formula ##STR1## wherein R.sub.1 is chlorine, bromine, fluorine or methyl;R.sub.2 and R.sub.3, which may be identical to or different from each other, are each hydrogen, chlorine or methyl;R.sub.4 is hydrogen, methyl or ethyl; andR.sub.5 and R.sub.6, which may be identical to or different from each other, are each methyl, ethyl or alkoxy-alkyl of 2 to 4 carbon atoms or, together with each other and the nitrogen atom to which they are attached, form a 5-, 6- or 7-membered heterocycle which may contain an additional heteroatom, such as pyrrolidino, piperidino, morpholino, piperazino or hexamethyleneimino;And non-toxic, pharmaceutically acceptable acid addition salts thereof; the compounds as well as the salts are useful as antithrombotics.

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, chlorine, hydroxyl, trifluoromethyl, methyl or methoxy, andR.sub.2 is hydrogen, alkyl of 1 to 2 carbon atoms or benzyl;And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful as hypertensives.

Abstract: The invention relates to novel erythromycin derivatives, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as the salts are useful as antibacterials.

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is alkyl of 6 to 19 carbon atoms, andR.sub.2 is methyl or ethyl,And their non-toxic, pharmacologically acceptable acid addition salts; the compounds as well as the salts are useful as pharmaceuticals for the treatment of cardiac and circulatory insufficiencies.

Abstract: A topical pharmaceutical antiviral composition consisting essentially of an inert pharmaceutical carrier or diluent, a complex-former for bivalent cations, and a 5'-triphosphate of a nucleoside or deoxyribonucleoside.

Abstract: Pharmaceutical compositions containing as an active ingredient a compound of the formula ##STR1## wherein R.sub.1 is alkyl of 1 to 5 carbon atoms,R.sub.2 is hydrogen or lower alkyl,R.sub.3 is hydrogen or hydroxyl, andZ is alkylene of 2 to 6 carbon atoms,Or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as sympathomimetics.