Patents Assigned to Boehringer Ingelheim International GmbH
  • Dispensing device, storage device and method for dispensing a formulation
    Patent number: 10124129
    Abstract: The invention relates to a dispensing device, a storage device and a method for dispensing a medical formulation. Multiple doses of the formulation are stored in a carrier having multiple storage members, each storage member containing a single dose. Each storage member comprises one duct or nozzle for dispensing the respective dose. The dispensing direction of the ducts or nozzles is directed in a lengthwise or indexing direction of the carrier. The storage device of the carrier is a peelable blister strip, wherein the ducts or nozzles can be opened one after the other by peeling the blister strip.
    Type: Grant
    Filed: December 24, 2008
    Date of Patent: November 13, 2018
    Assignee: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Stephen T. Dunne, Achim Moser
  • Pharmaceutical dosage form for immediate release of an indolinone derivative
    Patent number: 10105323
    Abstract: The present invention relates to a pharmaceutical dosage form delivering an immediate release profile containing the active substance 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone-monoethanesulphonate.
    Type: Grant
    Filed: May 9, 2017
    Date of Patent: October 23, 2018
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Roman Messerschmid, Peter Lach, Torsten Sokoliess, Peter Stopfer, Dirk Trommeshauser
  • General process for the preparation of 6-substituted or 5,6-disubstituted derivatives of 2-amino-isonicotinic acid
    Patent number: 10106506
    Abstract: This invention relates to a novel synthetic method for the preparation of 6-substituted or 5,6-disubstituted derivatives of 2-amino-isonicotinic acid.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: October 23, 2018
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Weitong Dong, Da Deng, Yan Fu, Xiangle Jin, Lidong Xing, Jun Yan
  • Closure system for an applicator attachment on a container for pharmaceutical preparations, and use, container with closure system, syringe for medical purposes, and method of assembly
    Patent number: 10099012
    Abstract: Disclosed are a closure system for an applicator attachment on a container for pharmaceutical preparations and to a use of the closure system, a syringe for medical purposes, including a container for pharmaceutical preparations and a closure system, and a method of assembling a syringe. The aforementioned operate such that splash prevention and a venting function are integrated in the closure system.
    Type: Grant
    Filed: March 19, 2013
    Date of Patent: October 16, 2018
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Friedrich Haefele, Markus Hemminger, Tobias Sachsse, Klaus Boje
  • Nebulizer
    Patent number: 10099022
    Abstract: A nebulizer and a container with a fluid for such a nebulizer are described, the container comprising an indicator device fixedly mounted on the bottom of the container, the indicator device stopping further use of the container in a locked state when a predetermined number of uses has been reached or exceeded, and when the nebulizer is partially opened, it is blocked against further use, and after replacement of the container including the indicator device, the nebulizer can be used again.
    Type: Grant
    Filed: May 4, 2015
    Date of Patent: October 16, 2018
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Joachim Eicher, Josef Gatz, Frank Herrmann, Hubert Hoelz, Andree Jung, Martin Meisenheimer, Markus Mueller, Alfred Von Schuckmann, Herbert Wachtel, Robert Gerhard Winkler, Gilbert Wuttke, Jochen Ziegler
  • Treatment of genotyped diabetic patients with DPP-IV inhibitors such as linagliptin
    Patent number: 10092571
    Abstract: The present invention relates to methods for preventing or treating of metabolic disorders and related conditions, such as in certain patient groups.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: October 9, 2018
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Klaus Dugi, Eva Ulrike Graefe-Mody, Michael Mark, Hans-Juergen Woerle, Heike Zimdahl-Gelling
  • Nebulizer
    Patent number: 10080853
    Abstract: A nebulizer is proposed as depicted in exemplary FIG. 7 which comprises a replaceable container, a counting device and a lock for locking the nebulizer against further use. The container is provided with an electronic storage which is electrically connected to the counting device. The nebulizer comprises an electric drive for actuating the lock. This allows secure operation and/or simple handling of the nebulizer.
    Type: Grant
    Filed: May 21, 2012
    Date of Patent: September 25, 2018
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Holger Holakovsky, Marc Rohrschneider, Florian Witte, Kevin Peter Deane, Douglas Ivan Jennings, Charles Henderson
  • Uses of DPP IV inhibitors
    Patent number: 10080754
    Abstract: The specification describes the use of selected DPP IV inhibitors for the treatment of physiological functional disorders and for reducing the risk of the occurrence of such functional disorders in at-risk patient groups. In addition, the use of the above-mentioned DPP IV inhibitors in conjunction with other active substances is described, by means of which improved treatment outcomes can be achieved. These applications may be used to prepare corresponding medicaments.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: September 25, 2018
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Klaus Dugi, Frank Himmelsbach, Michael Mark
  • Morpholine and 1,4-oxazepane amides as somatostatin receptor subtype 4 (SSTR4) agonists
    Patent number: 10071974
    Abstract: The invention relates to morpholine and 1,4-oxazepane amide derivatives of general formula (I), which are agonists of somatostatin receptor subtype 4 (SSTR4), useful for preventing or treating medical disorders related to SSTR4. In addition, the invention relates to processes for preparing pharmaceutical compositions as well as processes for manufacture of the compounds according to the invention.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: September 11, 2018
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Rocco Mazzaferro, Marco Ferrara, Riccardo Giovannini, Iain Lingard, Klaus Rudolf
  • VIBRATING BLISTER
    Publication number: 20180243519
    Abstract: Disclosed is an inhaler and a method for using the inhaler for the inhalation of a formulation from a carrier. The carrier contains the formulation in a receptacle and is set oscillating by an air current. An improved or defined delivery and nebulisation of the preferably powdered formulation is made possible by the fact that the carrier is set oscillating in defined manner, the formulation is dispensed through a cover element having three to five holes and/or the air current flows onto a fin associated with the carrier and flows past at least substantially only one flat side of the carrier.
    Type: Application
    Filed: May 1, 2018
    Publication date: August 30, 2018
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Andree JUNG, Stephen Terence DUNNE
  • Compound targeting IL-23A and TNF-alpha and uses thereof
    Patent number: 10059763
    Abstract: The disclosure relates to compounds specific for IL23A and TNF-alpha, compositions comprising the compounds, and methods of use thereof. Nucleic acids, cells, and methods of production related to the compounds and compositions are also disclosed.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: August 28, 2018
    Assignees: BOEHRINGER INGELHEIM INTERNATIONAL GMBH, MACROGENICS, INC.
    Inventors: Rachel Rebecca Barrett, Leslie S. Johnson, Sanjaya Singh, Kathleen Last-Barney, Daw-Tsun Shih, Patricia Giblin, Scott Brodeur, Nelamangala Nagaraja
  • Azabenzimidazole derivatives
    Patent number: 10053471
    Abstract: The present invention relates to compounds of general formula (I), wherein R1, R2, R3, A1, A2, m and n are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the AMP-activated protein kinase (AMPK) and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: August 21, 2018
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Frank Himmelsbach, Elke Langkopf
  • Nebulizer
    Publication number: 20180221603
    Abstract: A nebulizer is proposed which comprises a blocking device for blocking opening of the nebulizer in a tensioned state. The nebulizer comprises preferably an indicator device for indicating a tensioned state of the nebulizer. The nebulizer comprises further a depressable actuator member at a housing part which is detachable from the nebulizer.
    Type: Application
    Filed: April 2, 2018
    Publication date: August 9, 2018
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Jens Besseler, Frank Herrmann, Holger Holakovsky, Herbert Argauer, Josef Gatz, Andreas Gorshoefer
  • Process for the manufacture of 4-aminobenzoamidine dihydrochloride
    Patent number: 10040750
    Abstract: The present invention relates to a process for the preparation of 4-aminobenzoamidine (4-AMBA) salts of general formula (I) preferably the salts thereof with hydrochloric or hydrobromic acid, particularly preferred the dichloride salt.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: August 7, 2018
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Weitong Dong, Christian Wolfgang Hemp, Xiangle Jin, Jun Lu, Ulrich Scholz, Shengmin Su, Wei Xu, Jinsong Yang
  • Treatment for diabetes in patients inappropriate for metformin therapy
    Patent number: 10034877
    Abstract: The present invention relates to the finding that certain DPP-4 inhibitors are particularly suitable for treating and/or preventing metabolic diseases, particularly diabetes, in patients for whom metformin therapy is inappropriate due to intolerability or contraindication against metformin.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: July 31, 2018
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Klaus Dugi, Eva Ulrike Graefe-Mody, Ruth Harper, Hans-Juergen Woerle
  • Cyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxyamide
    Patent number: 10023575
    Abstract: The invention relates to Spirocyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxyamide of general formula (I) which are inhibitors of phosphodiesterase 2, useful in treating central nervous system diseases and other diseases. In addition, the invention relates to processes for preparing pharmaceutical compositions as well as processes for manufacture the compounds according to the invention.
    Type: Grant
    Filed: October 12, 2016
    Date of Patent: July 17, 2018
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Christoph Hoenke, Barbara Bertani, Marco Ferrara, Giacomo Fossati, Sara Frattini, Riccardo Giovannini, Scott Hobson
  • DPP-IV inhibitor combined with a further antidiabetic agent, tablets comprising such formulations, their use and process for their preparation
    Patent number: 10022379
    Abstract: The present invention relates to pharmaceutical compositions comprising fixed dose combinations of a DPP-4 inhibitor drug and a partner drug, processes for the preparation thereof, and their use to treat certain diseases.
    Type: Grant
    Filed: January 11, 2017
    Date of Patent: July 17, 2018
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Thomas Friedl, Michael Braun, Kenji Egusa, Hikaru Fujita, Megumi Maruyama, Takaaki Nishioka
  • 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
    Patent number: 10023574
    Abstract: The present invention relates to substituted xanthines of general formula wherein R1 to R3 are as defined herein, the tautomers, the stereoisomers, the mixtures, the prodrugs thereof and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: July 17, 2018
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Frank Himmelsbach, Elke Langkopf, Matthias Eckhardt, Roland Maier
  • Nebulizer
    Patent number: 10016568
    Abstract: A nebulizer is proposed which includes an insertable container and a securing mechanism for holding the container in the nebulizer such that the container can move back and forth but can not be separated. The securing mechanism is formed by a metal unitary part. The securing mechanism forms a transportation lock for holding the container unmovable in the housing in a delivery state of the nebulizer. The securing mechanism forms a ring with flexible holding fingers.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: July 10, 2018
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Alexander Bach, Jens Besseler, Holger Holakovsky, Manuel Daelman, Gilbert Wuttke, Udo Frenkel
  • Atomizer
    Patent number: 10004859
    Abstract: The invention relates to an apparatus for nebulizing preferably powdered medicinal formulations, the nebulization being assisted by propellant. According to the invention, the propellant is supplied in pulsed form to the powder cavity (1) containing the formulation, which is attached to the nozzle (3) from which the aerosol is emitted. The apparatus according to the invention provides an increase in the fraction of pulmonary particles in the aerosol leaving the nozzle (3).
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: June 26, 2018
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Robert Gerhard Winkler, Herbert Wachtel, Stephen Terence Dunne, Andree Jung