Abstract: The invention relates to a method for measuring the scattered light (L2) of particles (P, PK) in a measuring medium (F), wherein a measuring container (1) is supplied with the measuring medium (F) and incident light (L1) is shone through the measuring medium (F) at least in some regions over a certain path length (1) and in a certain direction and the light (L2) scattered from the incident light (L1) is measured within a certain angle range (?). It is provided according to the invention that the incident light (L1) is guided parallel to a longitudinal axis (S) of the measuring container (1). By these measures, known methods can be improved and it is readily possible to use the invention even for very small measuring volumes of the measuring medium (F) with the associated small dimensions of the measuring container (1).

Abstract: A device and a process are proposed for separating constituents of a sample fluid, wherein the sample fluid is supplied by capillary force to a receiving region (7) for metering, stopping or delaying the sample fluid and the sample fluid is pre-treated with a soluble chemical (13) in the receiving region (7) before the sample fluid is supplied to a separating device (5) for separating off constituents of the sample fluid.

Abstract: The invention relates to a microfluidic structure (1), comprising at least one cavity (10) having at least one inlet opening (11) and at least one outlet opening (12), wherein the cavity (10) can be filled with a liquid or a liquid can flow through the cavity and at least one element (13) is provided inside the cavity (10), which element stops the flow of the liquid at least temporarily and/or diverts the flow of the liquid at least in some regions within the cavity (10). According to the invention, the at least one element (13) is formed by a recess (13) introduced into a wall of the cavity (10), which recess (13) has at least one first region (14) at which the liquid stops at least temporarily and/or is diverted at least in some regions and at least one second region (15) at which the liquid preferably flows into the recess (13). Such a microfluidic structure makes it possible to fill the cavity (10) without air inclusions.

Abstract: The invention relates to a container (1) for a fluid for metering a reagent into a microfluidic system. The container comprises a chamber (4) and a first film (3) which seals off the chamber (4) so that the fluid is encapsulated in the chamber. Advantageously, the first film (3) is an aluminum sealing film. A second film (7) is sealingly arranged on the first film, for example by adhesive bonding of the film layers. The films differ in their tear strength such that when pressure is applied simultaneously to both films the first film tears while the second film deforms elastically and/or plastically. By tearing the first film a connection is produced between the container chamber and an inlet channel so that a fluid contained in the chamber flows into the microfluidic system.

Abstract: The invention relates to a microfluidic platform (1) having at least one means (12) for initiating a movement of a liquid (P), in particular a sample liquid, between at least two locations (100, 101) of the microfluidic platform (1). It is proposed according to the invention that the means (12) is embodied as an element of changeable volume and/or shape and is mounted on a cover-like component (11) that is movably connected to the microfluidic platform (1). By moving of the component (11) the element (12) can be brought into a position such that, by changing its volume and/or shape, it causes the liquid (P) situated at the location (100) to be moved at least partly from this location (100) to the other location (101). In this way a sample liquid (P) can be transferred from a sample application point (100) to a sample utilisation area (101) in a very simple and reliable manner.

Abstract: The invention relates to a method for mixing at least one sample solution (P) with at least one reagent (R) in at least one chamber (2) of a microfluidic cartridge (MC) and a device for carrying out the method. It is provided according to the invention that at least one reagent (R) is supplied to the sample solution (P) and brought into contact therewith by means of at least one movable component (11). In this way the loss of sample liquid (P) or analyte can be reduced. A device for carrying out the method is also proposed.

Abstract: The invention relates to a method for washing at least one cavity (20?) in a microfluidic component, the cavity (20?) containing a first liquid (F1) and at least one second liquid (F2) being supplied to the cavity (20?) for washing. According to the invention an air bubble (L) is supplied to the cavity (20?) before the washing liquid (F2) is introduced. The air bubble (L), which acts as a virtual barrier layer between the first liquid (F1) and the washing liquid (F2) that follows it enables the washing efficiency to be increased considerably. Overall, this method leads to a saving in washing liquid (F2) and washing time. Moreover, a microfluidic component is proposed for carrying out the method.

Abstract: The invention relates to a device and a method for cleaning sample material, in particular nucleic acids. The cleaning process takes place by means of centrifugal microfluidics and the invention provides a simple compact construction and a simple procedure. If necessary, the sample material is easily mixed with a solvent buffer and proteases in the device. The cleaned sample material is in particular transferred directly to a container. Separate containers for the removal of excess liquid are not required.

Abstract: Method for completely filling a cavity, in particular a blister of a blister packaging, with a liquid, and semifinished product for use in such a method. The invention relates to a method for filling at least one cavity (11), particularly a blister of a blister packaging, with a liquid (F) and comprises at least the following steps: partly filling (S1) a cavity (10) of a semifinished product (1) containing at least two cavities (10, 11) with the liquid (F), covering (S2) the semifinished product (1) at least in some areas, so as to prevent the escape of liquid (F) from the semifinished product (1), displacing (S4) at least some of the liquid (F) from the already partially filled cavity (10), such that at least one other cavity (11) is completely filled by a portion of the displaced liquid and another portion of the displaced liquid at least partially fills at least one overflow (12).

Abstract: The invention relates to a device and a method for filtering a liquid sample, wherein first capillary-driven filtration occurs and, after initial filling, pressure-operated filtration is performed by applying a vacuum or a positive pressure.

Abstract: A device, particularly a microfluidic system, is proposed, in which two cavities are arranged spatially close to one another and are sealed off from one another by a common cover. A fluidic connection can be produced between the cavities by movement of a pin-shaped body towards the cover. In this way it is possible to release a reagent in controlled manner without having to put it under pressure.

Abstract: A device and a method for separating a supernatant of a liquid sample are proposed, in which an outlet is closed off by a water-soluble membrane that dissolves after a certain length of time so that the supernatant of the sample is automatically drained away after centrifugation. The water-soluble membrane may in principle may also be used for other purposes for temporarily retaining a liquid in a holding chamber.

Abstract: A device and a method are proposed for actuating a carpule, in which a piston is displaced in the carpule by means of a ram that is telescopically extensible by rotation, and in this way a liquid medicament formulation is expelled. For carrying out different processes, different operating movements are provided, particularly the operation of an operating element in different directions and/or the operation of different operating elements. This promotes simple, intuitive and safe operation.

Abstract: A method for filling a cavity, of a packaging, particularly a blister packaging, with a liquid and a packaging suitable for this purpose are proposed. The cavity is completely filled with the liquid by an acceleration force or by continuous throughflow.

Abstract: A packaging is proposed, particularly a blister packaging, having at least one cavity for holding a liquid. The packaging comprises a capillary stop for the liquid which surrounds the cavity.

Abstract: A device is proposed having a separating device for filtering a liquid sample and having a conveying device. A positive pressure or negative pressure can be generated by means of the conveying device, for accelerating or assisting the filtration.

Abstract: A packaging, particularly a blister packaging, is proposed, having at least one cavity for holding a liquid and having an integrated opening device. The packaging can be used as a reservoir for a liquid for connecting to a fluidic assembly. The packaging is opened by partial deformation of the packaging.

Abstract: A device for the intake or manipulation of a fluid, in particular, a liquid, and a method for the production of a device of this type in which a flat, non-preformed covering film is laminated onto a carrier, a three-dimensionally shaped or convex chamber wall being formed solely by means of the laminating process. The chamber wall which forms a boundary of a chamber for the fluid is partially deformable. The device is simple to produce and can be used universally.

Abstract: A microfluidic device meters liquids into a network of channels or chambers partly formed by a film partly attached to and above a substrate, the network permitting flow of fluid above the substrate. To form a channel or chamber, the edge zone between unattached and attached portions of the film forms a wedge of material by viscous flow of film material as the film is laminated to the substrate, this wedge forming a transition between the chamber wall and the substrate, raising the wall above the plane of the substrate. Film is laminated with a mask having an opening, the mask pressed onto the film under pressure and/or with heat. The film is brought to a temperature to produce a viscous flow of film and/or substrate medium into the region of the opening, forming a wedge of material as the film bulges up at the opening to form a chamber.

Abstract: In a method of producing trench-like depressions (24) in the surface of a wafer (27), particularly a silicon wafer, by plasma etching, in which the depressions (24) are produced by alternate passivation and etching, each depression (24) in its final geometry is provided with a protective layer (30) of the polytetrafluoroethylene type.