Abstract: The present invention relates to mouse and human J12 polynucleotides, polypeptide and anti J12 antibody molecules. The J12 is a cytokine that is preferentially expressed in Th2 cells. The polypeptides and/or antibodies described herein can be used in methods for detection and treatment of certain autoimmune and inflammatory diseases including asthma.
Type:
Application
Filed:
October 6, 2009
Publication date:
February 11, 2010
Applicant:
Boehringer Ingelheim Phamaceuticals, Inc.
Inventors:
Jianfei Yang, Frank James King, Jun Li, Zhen Hao Qi, Ming Xue
Abstract: Disclosed are compounds of formula (I): wherein R1 and R2 are defined herein, which are useful as inhibitors of the kinase activity of the I?B kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
Type:
Grant
Filed:
December 6, 2003
Date of Patent:
December 13, 2005
Assignee:
Boehringer Ingelheim Phamaceuticals, Inc.
Inventors:
Charles L. Cywin, Can Mao, Jonathan Emeigh, Roman Wolfgang Fleck, Ming-Hong Hao, Eugene Hickey, Weimin Liu, Daniel Richard Marshall, Tina Morwick, Peter Nemoto, Ronald John Sorcek, Sanxing Sun, Jiang-Ping Wu, Erick Young, Darren DiSalvo, John Ginn, Pier Cirillo
Abstract: This invention relates to methods and compositions for targeting proteins to secretory lysosomes. The invention further provides methods of use in drug screening assays, and methods of purifying secretory lysosomes.
Type:
Application
Filed:
August 8, 2003
Publication date:
April 29, 2004
Applicant:
Boehringer Ingelheim Phamaceuticals, Inc.