Abstract: Compounds of the class of pyrido[2,3-b][1,4]benzoxazepin (and thiazepin)-6(5H)-ones and -thiones, having the following general structural formula ##STR1## wherein either X or Z is sulfur and the other substituent is oxygen or both X and Z are sulfur, which are inhibitors of HIV-1 reverse transcriptase and useful in the treatment of HIV-1 infection. An exemplary compound is 2-chloro-5-(methylthioethyl)pyrido[2,3-b][1,4]benzoxazepin-6(5H)one.
Type:
Grant
Filed:
August 17, 1994
Date of Patent:
August 20, 1996
Assignee:
Boehringer Ingelheim Pharamceuticals, Inc.
Inventors:
Karl D. Hargrave, Gunther Schmidt, deceased