Patents Assigned to Boehringer Ingelheim Pharmaceuticals, Inc.
  • Anti-cytokine heterocyclic compounds
    Publication number: 20060079519
    Abstract: Disclosed compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
    Type: Application
    Filed: March 7, 2005
    Publication date: April 13, 2006
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Derek Cogan, Ming-Hong Hao, Victor Kamhi, Matthew Netherton, Alan Swinamer, Craig Miller
  • Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
    Publication number: 20060079544
    Abstract: The present invention relates to a method for the prevention or the treatment of alveolar pneumonia comprising administration of a therapeutically effective amount of an anticholinergic 1, medicaments for the prevention or treatment of alveolar pneumonia comprising one or more, preferably one anticholinergic 1, and methods for the preparation of these medicaments.
    Type: Application
    Filed: July 28, 2005
    Publication date: April 13, 2006
    Applicants: Boehringer Ingelheim International GmbH, Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Klaus Viel, Steven Kesten
  • Intermediate arylamine compounds
    Patent number: 7026476
    Abstract: Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are and pharmaceutical compositions containing, intermediate compounds and processes of making such compounds.
    Type: Grant
    Filed: April 28, 2003
    Date of Patent: April 11, 2006
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Pier F. Cirillo, Steffen Breitfelder, Usha R. Patel, John R. Proudfoot, Alan D. Swinamer
  • IKKalpha and IKKbeta specific inhibitors
    Publication number: 20060073120
    Abstract: A method for modulating NF-?B dependent gene transcription in a cell comprised of modulating IKK? and IKK? protein and protein activity in the cell. The present invention also provides siRNA compositions and methods thereof for modulating NF-?B dependent gene transcription.
    Type: Application
    Filed: September 30, 2005
    Publication date: April 6, 2006
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Jun Li, Xiang Li, Katrina Catron
  • Preparation of aryl intermediates
    Patent number: 7022883
    Abstract: Disclosed are methods of making aryl intermediate compounds of the formula (A) which are useful in the production of heteroaryl ureas, Y and P are defined herein below.
    Type: Grant
    Filed: November 17, 2003
    Date of Patent: April 4, 2006
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Jinhua J. Song, Zhulin Tan, Nathan K. Yee
  • Class of surfactant-like materials
    Publication number: 20060068007
    Abstract: This invention generally refers to a novel class of surfactant-like material that promotes the solubility of poorly soluble compounds.
    Type: Application
    Filed: September 16, 2005
    Publication date: March 30, 2006
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Jinjiang Li, Shirlynn Chen, George Gereg, Mariotte Corson
  • Compounds useful as anti-inflammatory agents
    Patent number: 7019006
    Abstract: Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such compounds.
    Type: Grant
    Filed: July 21, 2003
    Date of Patent: March 28, 2006
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Pier F. Cirillo, Steffen Breitfelder, Usha R. Patel, John R. Proudfoot, Alan D. Swinamer, Hidenori Takahashi, Thomas A. Gilmore, Rajiv Sharma
  • Cytokine inhibitors
    Publication number: 20060046986
    Abstract: Disclosed are compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
    Type: Application
    Filed: August 23, 2005
    Publication date: March 2, 2006
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Donghong Gao, Neil Moss, Ji Wang, Jiang-Ping Wu, Lifen Wu, Zhaoming Xiong
  • Method of treating diseases and conditions associated with an altered level of amyloid beta peptides and new enolcarboxamide compounds
    Publication number: 20060040928
    Abstract: A method of treating or preventing of a disease or condition associated with an increased level of isoforms of amyloid ? peptides (A?) and/or with a changed ratio of levels of A? isoforms and/or with the formation of plaques containing amyloid ? peptide (A?) isoforms in a mammal comprising administering to said mammal an therapeutically effective amount of a compound selected from the formulas Ia, Ib wherein V, W, Y, R2, R3, R5, R6, L1 and i are defined as in claim 1.
    Type: Application
    Filed: May 19, 2005
    Publication date: February 23, 2006
    Applicants: Boehringer Ingelheim Vetmedica GmbH, Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Klaus Bornemann, Guenter Trummlitz, Edward Lazer, Clara Miao, Bernd Beck, Frank Sams-Dodd, Dagmar Kugler, Klaus Klinder, Cornelia Dorner-Ciossek, Marcus Kostka
  • Glucocorticoid mimetics, methods of making them, pharmaceutical formulations, and uses thereof
    Publication number: 20060030561
    Abstract: A compound of Formula (I) wherein R1, R2, R3, R4, R5, and R6 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
    Type: Application
    Filed: October 5, 2005
    Publication date: February 9, 2006
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Rajashekhar Betageri, David Thomson, Yan Zhang, Renee Zindell
  • Anti aromatase compounds pharmaceutical compositions and uses thereof
    Publication number: 20060030608
    Abstract: Compounds of Formula (I) wherein R1, R2, R3, R4, R5, and R6 are as defined herein for Formula (IA) and Formula (IB), or a tautomer, prodrug, solvate, or salt thereof, pharmaceutical compositions containing such compounds, and methods of modulating estrogen receptor activity in a cell or patient or treating an estrogen receptor-mediated disorder, particularly breast and other cancers, in a patient in need thereof by administering an effective amount of compound of the invention thereto.
    Type: Application
    Filed: May 25, 2005
    Publication date: February 9, 2006
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Richard Nelson, Pingrong Liu, John Proudfoot, Doris Riether, Christian Hanke Harcken, David Thomson
  • Methods for improving cell line activity in immunoisolation devices
    Publication number: 20060029584
    Abstract: Methods for maintaining and improving the secretory activity of cells housed in immunoisolation devices.
    Type: Application
    Filed: September 27, 2005
    Publication date: February 9, 2006
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Richard Schneiderman, Revati Tatake, Randall Barton
  • Synthesis of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides
    Publication number: 20060025447
    Abstract: Disclosed is a multi-step process for preparing a compound of Formula I: wherein R1 to R3 are as defined herein. The compounds of formula I inhibit the binding of human intercellular adhesion molecules to the Leukointegrins. As a result, these compounds are useful in the treatment of inflammatory and immune cell-mediated diseases.
    Type: Application
    Filed: July 25, 2005
    Publication date: February 2, 2006
    Applicants: Boehringer Ingelheim Pharmaceuticals, Inc., Boehringer Ingelheim International GmbH
    Inventors: Xiao-Jun Wang, Thomas Wirth, Thomas Nicola, Li Zhang, Rogelio Frutos, Yibo Xu, Dhileopkumar Krishnamurihy, Laurence Nummy, Richard Varsolona, Chris Senanayake, Jutta Kroeber
  • Pyrimidine derivatives useful as inhibitors of PKC-theta
    Publication number: 20060025433
    Abstract: Disclosed are novel compounds of formula (I): wherein X, Y, R1, R2 and R3 are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC-theta, including immunological disorders and type II diabetes. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Application
    Filed: July 6, 2005
    Publication date: February 2, 2006
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Antonio Barbosa, Steven Brunette, Eugene Hickey, Jin Kim, Michael Lawlor, Rene Lemieux, Bryan McKibben, Matt Tschantz, Hui Yu
  • Pharmaceutical compositions for the treatment of female sexual disorders
    Publication number: 20060025420
    Abstract: The invention relates to a method for the treatment of female sexual disorders comprising administration of a therapeutically effective amount of a compound of general formula 1 wherein the groups R, L and X may have the meanings specified in the description and claims.
    Type: Application
    Filed: July 22, 2005
    Publication date: February 2, 2006
    Applicants: Boehringer Ingelheimn International GmbH, Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Ulrich Brauns, Arne Froemder, Robert Pyke
  • Apparatus for automated synthesis
    Patent number: 6991766
    Abstract: Disclosed is an apparatus for automated synthesis containing a shaker deck with a plurality of reaction blocks containing a plurality of reaction wells, an arm containing an array of extending units capable of actuating physical steps along a plurality of axes of each reaction block, each reaction block being situated on a turntable, each turntable being further capable of rotating the reaction block along a central axis. Also disclosed are methods of preparing a peptide, oligonucleotide an small molecules using the apparatus.
    Type: Grant
    Filed: July 18, 2003
    Date of Patent: January 31, 2006
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Gregory Paul Roth, Roy Lewis Barr, Junefredo Fajardo Apon, Steven Russell Bush, Thomas James Baiga
  • Method to identify and analyze genes having modified expression in stimulated T cells
    Publication number: 20060019303
    Abstract: A method of identifying genes involved in the stimulation of primary T cells comprising the steps of: a) contacting experimental cells with a stimulating agent; b) preparing RNA from said experimental cells at one or more stimulation phases; c) measuring the level of gene expression in the cells; d) comparing the levels of gene expression of said experimental cells to the level of gene expression in control cells that have not been exposed to an stimulation agent; e) identifying genes that are up regulated or down regulated in said experimental cells relative to said control cells.
    Type: Application
    Filed: July 22, 2005
    Publication date: January 26, 2006
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Brian Castle, Jianfei Yang, Xiang Li, Jun Li
  • Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
    Publication number: 20060014787
    Abstract: A compound of Formula (IA) or Formula (IB) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
    Type: Application
    Filed: September 9, 2005
    Publication date: January 19, 2006
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Thomas Kirrane, Daniel Kuzmich, John Proudfoot, Hossein Razavi, David Thomson
  • Compounds useful as reversible inhibitors of cysteine proteases
    Patent number: 6982272
    Abstract: Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (I), (II), (Ia) and (Ib) further defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds.
    Type: Grant
    Filed: April 24, 2003
    Date of Patent: January 3, 2006
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Michel Jose Emmanuel, Eugene R. Hickey, Weimin Liu, Denice Mary Spero, Sanxing Sun, David S. Thomson, Yancey David Ward, Erick Richard Roush Young
  • Method and system for assisted culling and reformatting of encoded microtubes
    Patent number: 6981640
    Abstract: A method and system for aiding the selecting/culling or reformatting of encoded containers stored in a multi-rack array with respect to certain desired characteristics of compositions held within the containers employing a corresponding graphical interface that indicates the physical position of the containers within the array, and selection operations to be performed with respect to one or more containers in the array.
    Type: Grant
    Filed: August 27, 2003
    Date of Patent: January 3, 2006
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Michael Stanley Routburg, Kenneth Hendrata