Abstract: The present invention relates to an immunogenic composition comprising: a) a modified live H3 virus of swine influenza, and b) a modified live H1 virus of swine influenza. Furthermore, the present invention relates to methods for immunizing a subject comprising administering to such subject the immunogenic composition of the present invention. Moreover, the present invention relates to methods of treating or preventing clinical signs caused by swine influenza virus in a subject of need, the method comprising administering to the subject a therapeutically effective amount of an immunogenic composition according to the present invention.
Type:
Grant
Filed:
February 23, 2016
Date of Patent:
July 24, 2018
Assignee:
Boehringer Ingelheim Vetmedica GmbH
Inventors:
Marc Allan Eichmeyer, Wesley Scott Johnson, Eric Martin Vaughn, Michelle L. Walz
Abstract: A connecting system for providing a fluidic connection, preferably between containers, wherein the connecting system has at least two connecting arrangements configured to produce the fluidic connection, the connecting arrangements each having an opening region which is fluidically sealed in an initial state and is, in particular, film-shaped, brittle, fragile and/or unstable, and wherein the opening regions are each covered in sterile or sterilizable manner.
Type:
Application
Filed:
June 14, 2016
Publication date:
July 19, 2018
Applicant:
Boehringer Ingelheim Vetmedica GmbH
Inventors:
Marcus Rainer RAHMEL, Guido ENDERT, Jonas RUF, Horst WERGEN
Abstract: The present invention belongs to the field of animal health and provides means to study Porcine Reproductive and Respiratory Syndrome (PRRS), a viral disease affecting swine, and for the development of vaccines, therapeutics and diagnostics for the prophylaxis, treatment and diagnosis of PRRS. In a first consideration, the invention relates to a new PRRS virus variant, and, in a second consideration, to a nucleic acid sequence which comprises the genome of an infectious genotype I (EU) PRRS virus clone. Based on this, new PRRS vaccine candidates with improved properties are provided.
Type:
Grant
Filed:
December 19, 2014
Date of Patent:
July 3, 2018
Assignee:
BOEHRINGER INGELHEIM VETMEDICA GMBH
Inventors:
Andreas Gallei, Christoph Keller, Erik Schacht, Marieke Herrel
Abstract: Packages that include at least one medicament therein include at least one light member affixed thereto that is capable of emitting light upon activation. The light member is activated upon the opening of the package such that, upon opening, the light member fluoresces or otherwise emits light to provide information to an end user. In some embodiments, the light generated by the light member allows the end user to locate the package in dark conditions. In other embodiments, the light generated by the light member may be configured to emit only for a time period equal to a viability time period of the medicament within the package or to change color at a time period equal to the viability time period of the medicament within the package to alert an end user that the medicament is no longer useable.
Abstract: A container system having at least two containers, wherein the container system comprises a light member which is configured to provide information through the emission of light, wherein the container system is configured to provide or trigger the light member to provide the information through the emission of light when a step related to preparing a mixture of contents of the containers is performed. In particular, triggering occurs when the containers are separated from one another and/or when a fluidic connection is created between the containers.
Abstract: An inhaler with a respiration indicator, whereby the inhaler has a chamber wall forming a chamber and a dispensing device for fluidic connection of the chamber to a bodily opening, preferably a nostril, whereby the respiration indicator has a wall section of the chamber wall or is formed in this way, whereby the wall section is designed to indicate a respiratory activity by deformation and/or movement.
Type:
Application
Filed:
February 6, 2018
Publication date:
June 14, 2018
Applicant:
Boehringer Ingelheim Vetmedica GmbH
Inventors:
Marcus Knell, Guido Endert, Horst Wergen
Abstract: A device for detecting chemical or biochemical substances in fluids for use in an electrochemical camera. The device includes a first carrier having a sensor array with a plurality of electrochemical sensors. A second carrier includes a porous layer having at least one functional region, in which specifically binding capturing molecules are immobilized. The at least one functional region is arranged directly adjacent to at least one non-functionalized region. Assigned to the at least one functional region and the at least one non-functionalized region are several sensors of the sensor array, for use as the electrochemical camera.
Type:
Grant
Filed:
March 2, 2010
Date of Patent:
June 12, 2018
Assignee:
Boehringer Ingelheim Vetmedica GmbH
Inventors:
Alexander Frey, Walter Gumbrecht, Peter Paulicka, Meinrad Schienle, Manfred Stanzel
Abstract: An aqueous cyclodextrin-free solution of meloxicam suitable is provided for administration by needleless injection, containing a pharmacologically acceptable meloxicam salt of an organic or inorganic base and one or more suitable excipients.
Type:
Grant
Filed:
October 29, 2014
Date of Patent:
June 12, 2018
Assignee:
Boehringer Ingelheim Vetmedica GmbH
Inventors:
Martin A. Folger, Stefan Henke, Bernhard Hassel, Bernd Zierenberg
Abstract: The present invention relates i.a. to a CSFV (classical swine fever virus) comprising a substitution of proline to lysine at amino acid position 44 of the E2 protein and a substitution of threonine to aspartic acid at amino acid position 45 of the E2 protein. Further, the present invention provides an immunogenic composition comprising the CSFV of the present invention and the use of the immunogenic composition for reducing the incidence of or severity in an animal of one or more clinical signs associated with CSF. Moreover, the present invention provides a method of differentiating animals infected with CSFV from animals vaccinated with the immunogenic composition of the present invention.
Abstract: Aqueous cyclodextrin-free solution of meloxicam for administration by oral or parenteral route, containing a pharmacologically acceptable meloxicam salt of an organic or inorganic base and one or more suitable excipients, the content of dissolved meloxicam salt being more than 10 mg/mL. The formulation according to the invention has a shelf-life of up to 24 months or more.
Type:
Grant
Filed:
November 30, 2005
Date of Patent:
June 12, 2018
Assignee:
Boehringer Ingelheim Vetmedica GmbH
Inventors:
Stefan Henke, Bernd Kruss, Bernhard Hassel, Hans-Jurgen Kroff, Martin A. Folger, Klaus Daneck, Axel Prox
Abstract: A method for obtaining a saliva sample from an animal, particularly a pig, by means of a receiving device and a collecting device with an integrated filter, and a method of using a collecting device with an integrated filter for obtaining a saliva sample from an animal, particularly a pig. In addition, a collecting device comprising a bag, a removable container and a filter, and a kit having such a collecting device, and a receiving device for taking saliva from an animal, particularly a pig.
Abstract: Aqueous cyclodextrin-free solution of meloxicam for administration by oral or parenteral route, containing a pharmacologically acceptable meloxicam salt of an organic or inorganic base and one or more suitable excipients, the content of dissolved meloxicam salt being more than 10 mg/mL. The solution is for treating a mammal suffering from one or more of pain, inflammation, fever, acute mastitis, diarrhea, lameness, locomotor deficiency, or respiratory illness.
Type:
Grant
Filed:
October 19, 2016
Date of Patent:
May 1, 2018
Assignee:
Boehringer Ingelheim Vetmedica GmbH
Inventors:
Stefan Henke, Bernd Kruss, Bernhard Hassel, Hans-Juergen Kroff, Martin A. Folger, Klaus Daneck, Axel Prox
Abstract: A method is described for the treatment of systemic diseases in cats. A composition is administered to a cat, where the composition includes a therapeutically effective amount of angiotensin II receptor 1 (AT-1) antagonist (sartan).
Type:
Grant
Filed:
January 20, 2017
Date of Patent:
April 24, 2018
Assignee:
Boehringer Ingelheim Vetmedica GmbH
Inventors:
Marcus Stark, Ulrike D. Sent, Ingo Lang
Abstract: A solid tablet formed through direct compression of powder, the powder comprising meloxicam as an active ingredient and one or more excipients which are homogenously dispersed within the tablet that can be broken into two, three or four units with each unit containing equal amounts of the meloxicam.
Type:
Grant
Filed:
March 13, 2013
Date of Patent:
April 17, 2018
Assignee:
Boehringer Ingelheim Vetmedica GmbH
Inventors:
Martin A. Folger, Stefan Lehner, Horst Schmitt
Abstract: The present invention describes an efficient commercial scale production method for the preparation of PRRS virus.
Type:
Grant
Filed:
February 14, 2012
Date of Patent:
April 17, 2018
Assignee:
Boehringer Ingelheim Vetmedica GmbH
Inventors:
Elizabeth Jane Berry, Fuad Tawfiq Haddadin, Ali Khazraeinazmpour, Jeremy Kroll, Sonia Regina Cantisano Malburg, Edgar Arnulfo Sandoval Basurto, Stephen Scheerer
Abstract: A method for testing a biological sample wherein the sample is divided into a plurality of sample portions, is fed to a sensor arrangement in a first conveying direction and is carried away in a second conveying direction which is opposite to the first conveying direction, and/or a sensor cover is lowered onto a sensor apparatus multiple times. Furthermore, a cartridge for testing a biological sample wherein different fluidic circuits can be formed by actuating valves in the cartridge, and the sample or another fluid can be conveyed in the fluidic circuits by means of a pump apparatus.
Abstract: An analysis system and a method for testing a biological sample are proposed, wherein certain pieces of at least two different pieces of control information are selected and/or used to carry out the test using a cartridge and/or certain pieces of at least two different pieces of evaluation information are selected and/or used to evaluate the measurement results determined by the test.
Abstract: A cartridge, an analysis system and a method for analysing an in particular biological sample is proposed, wherein a first group having one or more valves and a second group having one or more valves can be or are actuated from different sides of the cartridge.
Abstract: An analysis system and a method for testing a biological sample wherein a plurality of assays selected from at least two assays from a group consisting of a protein assay for detecting a target protein, a nucleic-acid assay for detecting a target nucleic-acid sequence and/or an aptamer assay for detecting another target analyte, The testing is carried out sequentially in a common sensor array by means of a sensor apparatus.
Abstract: A cartridge, an analysis system, a method and a computer program product for testing a sample, such as, environmental, food or biological sample, wherein the cartridge has two memory means that are different and/or can be read out by different methods and which correspond to the cartridge or to the batch thereof.
Type:
Application
Filed:
October 5, 2017
Publication date:
April 12, 2018
Applicant:
Boehringer Ingelheim Vetmedica GmbH
Inventors:
Heinz Schoeder, Axel Niemeyer, Kai Wuerz