Abstract: Methods for preventing or treating inflammation are provided. Specifically, such inflammation can be effectively treated or prevented through the use of anti-ICAM-1 antibodies which have been modified to contain poly(ethylene) glycol adducts. The modification reduces the immunoreactivity of the antibodies, and thus increases the antibodies' serum half life. Methods for forming, purifying and using such modified antibodies are described.
Type:
Grant
Filed:
April 24, 1995
Date of Patent:
December 9, 1997
Assignee:
Boehringer Inglehiem Pharmaceuticals, Inc.
Inventors:
Ronald Bertrand Faanes, Paul Edward McGoff, Bret Allen Shirley, David Stuart Scher