Abstract: 2'-Deoxyisoguanosine, isosteric analogues and isoguanosine derivatives of formulae I-V, processes for their production via compounds of the general formulae a or b and reaction with aroyl isocyanates or from compounds of the general formulae VI-IX by photochemical irradiation. A further production process is the conversion of deoxyguanosines or guanosines by means of persilylation, reaction with ammonia and deamination in the 2 position. The compounds are suitable as pharmaceutical agents with antiviral efficacy.
Type:
Grant
Filed:
May 29, 1998
Date of Patent:
November 14, 2000
Assignee:
Boehringer Mannheim
Inventors:
Frank Seela, Zigmunt Kasimierczuk, Klaus Muhlegger, Herbert Von Der Eltz
Abstract: The present invention is concerned with the use of certain 3-aminopyrazolo-heterocyclic compounds for the colorimetric determination of hydrogen peroxide, hydrogen peroxide-forming systems, peroxidase, peroxidate-active substances and electron-rich aromatic compounds. The present invention is also concerned with corresponding processes of determination and with agents appropriate therefor. Furthermore, the present invention is concerned with new 3-aminopyrazolo-heterocyclic compounds.
Type:
Grant
Filed:
May 25, 1993
Date of Patent:
October 10, 1995
Assignee:
Boehringer Mannheim
Inventors:
Gerd Zimmermann, Joachim Siedel, Gunter Frey
Abstract: Pipette with elastic bellows wherein the travel of the bellows is limited by preset stops. The bellows is prestressed between the stops over a range of movement within which the bellows possesses adequate springback force to return to a rest position predetermined by one of the stops.
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