Patents Assigned to Boehringer Mannheim Italia, S.p.A.
  • 2-(acylthio)methyl dihydropyridines, and pharmaceutical compositions containing them
    Patent number: 4935433
    Abstract: Compounds of formula I wherein R.sub.1 is an alkoxy carbonyl, aminocarbonyl, acetyl, benzyl, cyano or nitro group; R.sub.2 is as optionally substituted phenyl, aryl, hetaryl residue; R.sub.3 is an alkoxy-carbonyl group, X is an oxygen or sulphur atom, R.sub.4 is hydrogen, an optionally substituted alkyl, cycloalkyl, alkenyl group, Y is a single bond oxygen, sulphur or substituted nitrogen atom.Compounds of formula I are prepared by acylation from a 2-mercaptomethyl-1,4-dihydropyridine and are useful in therapy.
    Type: Grant
    Filed: July 28, 1987
    Date of Patent: June 19, 1990
    Assignee: Boehringer Mannheim Italia, S.p.A.
    Inventors: Marco Frigerio, Carlo Riva, Andrea Zaliani, Carmelo A. Gandolfi, Odoardo Tofanetti, Sergio Tognella