Patents Assigned to Boehringer Mannheim Pharmaceuticals Corp.
  • Patent number: 6358990
    Abstract: A method of treating amyloid diseases by administering a compound of Formula I: wherein: R7-R13 are independently —H or —OH; and A is H, —OH, or a moiety of Formula II:  wherein: R1 is hydrogen, lower alkanoyl of up to 6 carbon atoms or aroyl selected from benzoyl and naphthoyl; R2 is hydrogen, lower alkyl of up to 6 carbon atoms or arylalkyl selected from benzyl, phenylethyl and phenylpropyl; R3 is hydrogen or lower alkyl of up to 6 carbon atoms; R4 is hydrogen or lower alkyl of up to 6 carbon atoms, or when X is oxygen, R4 together with R5 can represent —CH2—O—; X is a valency bond, —CH2, oxygen or sulfur; Ar is selected from phenyl, naphthyl, indanyl and tetrahydronaphthyl; R5 and R6 are individually selected from hydrogen, fluorine, chlorine, bromine, hydroxyl, lower alkyl of up to 6 carbon atoms, a —CONH2— group, lower alkoxy of up to 6 carbon atoms, benzyloxy, lower alkylthio of up to 6 carbon atoms,
    Type: Grant
    Filed: April 13, 2000
    Date of Patent: March 19, 2002
    Assignees: Boehringer Mannheim Pharmaceuticals Corp., SmithKline Beckman Corp. Limited Partnership No. 1
    Inventors: David Robert Howlett, Davina Elizabeth Mitchell