Patents Assigned to Bone Care International, Inc
  • Publication number: 20060003950
    Abstract: The invention provides therapeutic methods for inhibiting, ameliorating or alleviating the hyperproliferative cellular activity of diseases of the prostate, e.g., prostatic cancer and prostatic hyperplasia, which includes administering to a patient in need thereof an active vitamin D analogue and another anticancer agent. Cell differentiation is promoted, induced or enhanced without causing to the patient dose-limiting hypercalcemia and hypercalciuria.
    Type: Application
    Filed: June 30, 2004
    Publication date: January 5, 2006
    Applicant: Bone Care International, Inc.
    Inventors: Stephen Strugnell, Don Wigington
  • Publication number: 20060003021
    Abstract: The invention provides therapeutic methods for inhibiting, ameliorating or alleviating the hyperproliferative cellular activity of diseases of the breast, e.g., breast cancer, which includes administering to a patient in need thereof an active vitamin D analogue and another anticancer agent. Cell differentiation is promoted, induced or enhanced without causing to the patient dose-limiting hypercalcemia and hypercalciuria.
    Type: Application
    Filed: June 30, 2004
    Publication date: January 5, 2006
    Applicant: Bone Care International, Inc.
    Inventors: Stephen Strugnell, Don Wigington
  • Publication number: 20050239756
    Abstract: The present invention provides a method of increasing or maintaining blood concentrations of 1,25-dihydroxyvitamin D in a patient by administering an amount of 1?-hydroxyvitamin D2. The invention also provides a method of concurrently lowering or maintaining plasma intact parathyroid hormone levels, increasing or maintaining serum calcium levels, maintaining serum phosphorous levels, or increasing or maintaining serum 1,25-dihydroxyvitamin D levels in a human patient by administering to the patient an amount of 1?-hydroxyvitamin D2. The invention also provides a method of reducing the risk of over suppression of plasma intact parathyroid hormone levels in a patient undergoing treatment for elevated levels of plasma intact parathyroid hormone, by administering 1?-hydroxyvitamin D2 in an amount sufficient to decrease elevated intact parathyroid hormone levels while avoiding an abnormally low bone turnover rate.
    Type: Application
    Filed: April 25, 2005
    Publication date: October 27, 2005
    Applicant: Bone Care International, Inc.
    Inventors: Charles Bishop, Eric Messner, Keith Crawford
  • Patent number: 6929797
    Abstract: The present invention is directed to a conjugate which includes at least one vitamin D moiety thereof and at least one targeting molecule moiety to pharmaceutical compositions of the conjugate, and to methods for using the conjugate for target-specific delivery of vitamin D or analogs thereof to tissues in need thereof. When a particularly preferred form is administered to a patient, the targeting molecule component of the conjugate of this invention seeks out and binds to a tissue of interest, such as bone or tumor tissue, where the vitamin D has a therapeutic effect.
    Type: Grant
    Filed: February 13, 1998
    Date of Patent: August 16, 2005
    Assignee: Bone Care International, Inc.
    Inventors: Richard B. Mazess, Charles W. Bishop
  • Publication number: 20050148558
    Abstract: The invention provides a stabilized 1?-hydroxyvitamin D (“SHVD”) which is particularly well suited for pharmaceutical formulations.
    Type: Application
    Filed: February 24, 2005
    Publication date: July 7, 2005
    Applicant: Bone Care International, Inc.
    Inventors: Joyce Knutson, Richard Mazess, Charles Bishop
  • Patent number: 6903083
    Abstract: The invention provides a stabilized 1?-hydroxyvitamin D (“SHVD”) which is particularly well suited for pharmaceutical formulations.
    Type: Grant
    Filed: August 20, 2002
    Date of Patent: June 7, 2005
    Assignee: Bone Care International, Inc.
    Inventors: Joyce C. Knutson, Richard B. Mazess, Charles W. Bishop
  • Publication number: 20040058895
    Abstract: This invention relates to multi-use dispensing vessels containing pharmaceutical formulations of active vitamin D compounds.
    Type: Application
    Filed: June 27, 2003
    Publication date: March 25, 2004
    Applicant: Bone Care International, Inc.
    Inventors: Richard B. Mazess, Jeffrey W. Driscoll, Creighton Reed Goldensoph, Leon W. LeVan
  • Publication number: 20040053894
    Abstract: The invention relates to pharmaceutical formulations of lipophilic therapeutic agents in which such agents are solubilized in largely aqueous vehicles, and processes for preparing and using the same.
    Type: Application
    Filed: September 18, 2002
    Publication date: March 18, 2004
    Applicant: Bone Care International, Inc.
    Inventors: Richard B. Mazess, Jeffrey W. Driscoll, Creighton Reed Goldensoph, Leon W. LeVan
  • Publication number: 20040053895
    Abstract: This invention relates to multi-use dispensing vessels containing pharmaceutical formulations of active vitamin D compounds, and also to plastic blow fill containers containing active vitamin D formulations.
    Type: Application
    Filed: September 18, 2002
    Publication date: March 18, 2004
    Applicant: Bone Care International, Inc.
    Inventors: Richard B. Mazess, Jeffrey W. Driscoll, Creighton Reed Goldensoph, Leon W. LeVan
  • Publication number: 20040043971
    Abstract: This invention relates to a method for treating or preventing hyperthyroidism secondary to chronic kidney disease by administering a sufficient amount of an active vitamin D analog utilizing a variety of effective treatment protocols.
    Type: Application
    Filed: March 10, 2003
    Publication date: March 4, 2004
    Applicant: Bone Care International, Inc.
    Inventors: Richard B. Mazess, Stephen A. Strugnell, Joyce C. Knutson
  • Publication number: 20040023934
    Abstract: The invention provides therapeutic methods for inhibiting, ameliorating or alleviating the hyperproliferative cellular activity of diseases of the prostate, e.g., prostatic cancer and prostatic hyperplasia, which includes administering to a patient in need thereof an active vitamin D analogue. Cell differentiation is promoted, induced or enhanced without causing to the patient dose-limiting hypercalcemia and hypercalciuria.
    Type: Application
    Filed: March 25, 2003
    Publication date: February 5, 2004
    Applicant: Bone Care International, Inc.
    Inventors: Charles W. Bishop, Joyce C. Knutson, Richard B. Mazess
  • Patent number: 6680309
    Abstract: Methods for the utilization of hypocalcemic vitamin D analogs to inhibit the hyperproliferation of malignant or neoplastic cells without incidence of hypercalcemia.
    Type: Grant
    Filed: January 7, 2003
    Date of Patent: January 20, 2004
    Assignee: Bone Care International, Inc.
    Inventors: Charles W. Bishop, Richard B. Mazess
  • Publication number: 20040009958
    Abstract: A method of inhibiting the hyperproliferation of malignant or neoplastic cells, comprising treating the cells with an antiproliferative amount of 1&agr;,24(S)-dihydroxyvitamin D2. The method also includes the co-administration of cyotoxic agents with the 1&agr;,24(S)-dihydroxyvitamin D2.
    Type: Application
    Filed: March 18, 2003
    Publication date: January 15, 2004
    Applicant: Bone Care International, Inc.
    Inventors: Charles W. Bishop, Joyce C. Knutson, Stephen Strugnell, Richard B. Mazess
  • Publication number: 20030207810
    Abstract: Methods utilizing active vitamin D analogs for the treatment of malignancy-associated hypercalcemia. Methods comprise the application of an effective amount of a hypocalcemic vitamin D compound to alleviate hypercalcemia, lower serum parathyroid hormone related protein (PTHrP) levels.
    Type: Application
    Filed: May 20, 2003
    Publication date: November 6, 2003
    Applicant: Bone Care International, Inc.
    Inventors: Charles W. Bishop, Richard B. Mazess
  • Publication number: 20030129194
    Abstract: The present invention is directed to a conjugate which includes at least one vitamin D moiety thereof and at least one targeting molecule moiety to pharmaceutical compositions of the conjugate, and to methods for using the conjugate for target-specific delivery of vitamin D or analogs thereof to tissues in need thereof. When a particularly preferred form is administered to a patient, the targeting molecule component of the conjugate of this invention seeks out and binds to a tissue of interest, such as bone or tumor tissue, where the vitamin D has a therapeutic effect.
    Type: Application
    Filed: September 20, 2002
    Publication date: July 10, 2003
    Applicant: Bone Care International, Inc.
    Inventors: Richard B. Mazess, Charles W. Bishop
  • Publication number: 20030130242
    Abstract: Methods for the utilization of hypocalcemic vitamin D analogs to inhibit the hyperproliferation of malignant or neoplastic cells without incidence of hypercalcemia.
    Type: Application
    Filed: January 7, 2003
    Publication date: July 10, 2003
    Applicant: Bone Care International, Inc.
    Inventors: Charles W. Bishop, Richard B. Mazess
  • Patent number: 6573256
    Abstract: Methods utilizing active vitamin D analogs for the inhibition of angiogenesis associated with malignant and neoplasmic cells. Methods comprise the application of an effective amount of a hypocalcemic vitamin D compound to inhibit the angiogenesis of malignant cells, inducing the apoptosis of malignant cells, and regressing the growth of tumorous cells.
    Type: Grant
    Filed: June 26, 2001
    Date of Patent: June 3, 2003
    Assignee: Bone Care International, Inc.
    Inventors: Charles W. Bishop, Richard B. Mazess
  • Patent number: 6566353
    Abstract: Methods utilizing active vitamin D analogs for the treatment of malignancy-associated hypercalcemia. Methods comprise the application of an effective amount of a hypocalcemic vitamin D compound to alleviate hypercalcemia, lower serum parathyroid hormone related protein (PTHrP) levels.
    Type: Grant
    Filed: June 26, 2001
    Date of Patent: May 20, 2003
    Assignee: Bone Care International, Inc.
    Inventors: Charles W. Bishop, Richard B. Mazess
  • Patent number: 6538037
    Abstract: A method of inhibiting the hyperproliferation of malignant or neoplastic cells, comprising treating the cells with an antiproliferative amount of 1&agr;,24(S)-dihydroxyvitamin D2. The method also includes the co-administration of cyotoxic angents with the 1&agr;,24(S)-dihydroxyvitamin D2.
    Type: Grant
    Filed: June 26, 2001
    Date of Patent: March 25, 2003
    Assignee: Bone Care International, Inc.
    Inventors: Charles W. Bishop, Joyce C. Knutson, Stephen Strugnell, Richard B. Mazess
  • Patent number: 6537982
    Abstract: The invention provides therapeutic methods for inhibiting, ameliorating or alleviating the hyperproliferative cellular activity of diseases of the prostate, e.g., prostatic cancer and prostatic hyperplasia, which includes administering to a patient in need thereof an active vitamin D analogue. Cell differentiation is promoted, induced or enhanced without causing to the patient dose-limiting hypercalcemia and hypercalciuria.
    Type: Grant
    Filed: February 23, 1998
    Date of Patent: March 25, 2003
    Assignee: Bone Care International, Inc.
    Inventors: Charles W. Bishop, Joyce C. Knutson, Richard B. Mazess