Abstract: Provided herein are protein complexes comprising a sensor domain and a therapeutic domain linked by a linker, and methods of use thereof. In aspects of the present disclosure, activity of the therapeutic domain comprises a dependence on sensor domain binding to target markers.
Type:
Grant
Filed:
October 18, 2021
Date of Patent:
May 9, 2023
Assignee:
Bonum Therapeutics, Inc.
Inventors:
John Thomas Mulligan, Shannon Lee Okada, Justin Richard Killebrew, Diane Louise Hollenbaugh