Abstract: A process to prepare compounds of formula I ##STR1## in which n=0, 1 or 2 comprising the cyclization of compounds of formula II ##STR2## in which n=0, 1 or 2. The cyclization may be effected in the presence of an organic or inorganic base or thermally at a temperature in the range 40.degree.-160.degree. C.Compounds of formula II and certain analogues thereof are disclosed as cardiovascular agents.
Type:
Grant
Filed:
March 1, 1991
Date of Patent:
January 7, 1992
Assignee:
The Boots Co. PLC
Inventors:
Lachlan MaClean, David L. Roberts, Kenneth Barron, Kenneth J. Nichol, Albert E. Harrison
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