Abstract: A method for the treatment of heart failure in a mammal comprises the administration to the mammal of a quinolone of the general formula I, ##STR1## wherein m is 0 or 1; n is 0, 1 or 2; and R is hydrogen, halo, methyl or trifluoromethyl. A preferred method of the invention comprises the treatment of chronic heart failure in a mammal by the oral administration of a quinolone of formula I. Preferred compounds of formula I are 7-fluoro-1-methyl-3-methylsulphinyl-4-quinolone and 1-methyl-3-methylsulphonylmethyl-4-quinolone.

Abstract: A connector for medical tubing comprises two interengaging parts (1, 12). As one part is rotated relative to the other, screw-threads cause a tapered projection (13) to mate with a flared bore (6) to provide a fluid-tight seal. Further relative rotation causes the outer bevelled edge of the outer wall (16) of one of the parts to move further forward to sealingly engage the sloping wall (10) of the other part. The projection (13) and outer wall (16) are connected by a flexible membrane 19 to permit this further forward movement. The connector is particularly suited for use in continuous ambulatory peritoneal dialysis.

Abstract: Compounds of formula I ##STR1## in which R.sub.1 is C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-7 cycloalkyl, cycloalkylalkyl or optionally substituted phenyl; R.sub.2 is H or C.sub.1-3 alkyl; R.sub.3 and/or R.sub.4 are H, formyl, C.sub.1-3 alkyl, C.sub.3-6 alkenyl, C.sub.3-6 alkynyl, C.sub.3-7 cycloalkyl or R.sub.3 and R.sub.4 together with the nitrogen atom form a heterocyclic ring system; R.sub.5 and/or R.sub.6 are H, halo, CF.sub.3, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, C.sub.1-3 alkylthio or R.sub.5 and R.sub.6 together with the carbon atoms to which they are attached form a second benzene ring show therapeutic activity in the treatment of depression. Pharmaceutical compositions and processes for preparing compounds of formula I are disclosed.

Abstract: Bisimide resins having improved fracture toughness and resistance to microcracking comprise a mixture of,(a) a bisimide of the general formula (I) ##STR1## in which B represents a divalent radical containing a carbon-carbon double bond and A is a divalent radical containing at least two carbon atoms and(b) a polyisocyanate of the general formula (II)D(NCO).sub.x (II)in which x has a value of between 2 and 4 and D stands for an x-valent radical .

Abstract: The N-methyl-D-glucamine salt of (+)-2-(2-fluoro-4-biphenylyl)propionic acid, which is a novel compound with analgesic, anti-inflammatory and antipyretic properties and which is useful for treating inflammatory conditions including rheumatic disorders and as an analgesic. Pharmaceutical compositions containing the novel salt are also described. Also described are methods for preparing the novel salt by direct salification in an aqueous or non-aqueous medium, for example isopropanol, aqueous tetrahydrofuran, bis(methoxyethyl) ether and 4-methyl-1,3-dioxolan-2-one. Isopropanol is especially preferred.

Abstract: A dispenser of dispensing tabets one at a time has a reservoir, a chamber below the reservoir in which the tablets are arranged in a single layer and a dispensing passageway which leads to a dispensing orifice. The passageway is of such a width that a single column of tablets can be accommodated. The passageway is defined by portions of a moving slider member and can be moved from a non-dispensing position to a dispensing position. In this latter position the lowermost tablet is dispensed whereas the remaining tablets in the column are retained in the passageway by a fixed protuberance. One side of the passageway is resilient to minimize tablet damage. The slider member is adapted to assist the passage of tablets from the reservoir to the chamber.

Abstract: Novel quinolones of the general formula ##STR1## wherein n is 0, 1 or 2; R.sub.1 is C.sub.1-4 alkyl; and R.sub.3 is hydrogen, C.sub.1-4 alkyl, methoxy, methylthio, halo or trifluoromethyl. These compounds have antihypertensive activity and may be used for treating hypertension in mammals.The quinolones are administered in novel therapeutic compositions comprising a quinolone of the above general formula together with a pharmaceutically acceptable carrier.Processes for making the novel quinolones are described.

Abstract: An earth proving device which includes a solid state relay employing a light emitting diode and photoconductor pair operating on low current/low voltage. Operation of the solid state relay is followed by operation of electromagnetically-operable switches which control electrical connections of a power supply to an electrically-operated apparatus to allow passage of a higher current therethrough. Thus, the earth proving device protects the apparatus by first providing indications of the state of the circuit and earth connections to the apparatus with a low current/low voltage sensing signal before the application of power level current and voltage thereto.

Abstract: Novel compounds are described which are substituted benzophenone hydrazones. They have pesticidal activity, especially against insects and acarids, and pesticidal compositions and methods are described. Methods of making the compounds, and novel intermediates, are also described.