Abstract: The present invention describes novel boron containing pyrazole compounds, or their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their medical uses. The compounds of the invention have activity as Janus kinase (JAK) inhibitors and are useful in the in the treatment or control of inflammation, auto-immune diseases, cancer, and other disorders and indications where modulation of JAK would be desirable. Also described are methods of treating inflammation, auto-immune diseases, cancer, and other conditions that are susceptible to the inhibition of a Janus kinase by administering a compound herein described.
Type:
Grant
Filed:
December 13, 2021
Date of Patent:
November 28, 2023
Assignees:
BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC., BORAH, INC.
Inventors:
Alan Long, Chun Yu Liu, Chunliang Liu, Yasheen Zhou, Shon R. Pulley, Keith Andrew Newton Graham
Abstract: The present invention describes novel compounds, or their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their medical uses. The compounds of the invention have activity as Janus kinase (JAK) inhibitors and are useful in the in the treatment or control of inflammation, auto-immune diseases, cancer, and other disorders and indications where modulation of JAK would be desirable. Also described herein are methods of treating inflammation, auto-immune diseases, cancer, and other conditions susceptible to inhibition of JAK by administering a compound herein described.
Type:
Grant
Filed:
December 23, 2020
Date of Patent:
April 19, 2022
Assignee:
Borah, Inc.
Inventors:
Yasheen Zhou, Chunliang Liu, Yong-Kang Zhang, Marissa Aubrey, Chun Yu Liu