Patents Assigned to Boston Microfluidics
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Patent number: 11358138Abstract: A blood sample collection and/or storage device includes a two-piece housing that encompasses a port at which a fingertip blood sample is collected. After the sample is taken, the two-piece housing is moved to a closed position to protect the sample for storage and optionally process the sample.Type: GrantFiled: October 19, 2018Date of Patent: June 14, 2022Assignee: BOSTON MICROFLUIDICS INC.Inventor: Brandon T. Johnson
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Patent number: 10180421Abstract: Sample processing methods and systems to collect a biological sample. A device may be configured collect a predetermined volume of a sample in sample chamber, and seal the chamber upon activation. The device may be further configured to mix the mix the sample with a predetermined volume of a reagent and/or mix the sample and the reagent in a pre-determined ration.Type: GrantFiled: July 19, 2013Date of Patent: January 15, 2019Assignee: BOSTON MICROFLUIDICSInventors: Brandon T. Johnson, Kate E. Christian, Glenn H. Verner, Daniel Morgan
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Patent number: 9861978Abstract: A mechanically-actuated vacuum-controlled fluid collection system includes a mechanically-actuated vacuum controller (MAVC) to draw fluid into a chamber through the opening to the chamber. The system may include a releasable seal to seal the opening, and the MAVC may include a spring-loaded plunger to create a vacuum within the chamber when sealed. The system includes multiple fluid chambers, and may further include a single actuator or multiple corresponding actuators. The system may be configured to add a pre-loadable reagent to fluid drawn into the one or more chambers, and may be configured to add the reagent in proportion to a volume of the fluid. The system may be controllable to release collected fluid to another device, such as for assay and/or transport. The system may be configured to draw a liquid biological sample such as urine, and may include a fluid interface to draw fluid from a biological sample container.Type: GrantFiled: December 5, 2013Date of Patent: January 9, 2018Assignee: BOSTON MICROFLUIDICS, INC.Inventors: Brandon T. Johnson, Kate E. Christian, Glenn H. Verner
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Publication number: 20140341787Abstract: A mechanically-actuated vacuum-controlled fluid collection system includes a mechanically-actuated vacuum controller (MAVC) to draw fluid into a chamber through the opening to the chamber. The system may include a releasable seal to seal the opening, and the MAVC may include a spring-loaded plunger to create a vacuum within the chamber when sealed. The system includes multiple fluid chambers, and may further include a single actuator or multiple corresponding actuators. The system may be configured to add a pre-loadable reagent to fluid drawn into the one or more chambers, and may be configured to add the reagent in proportion to a volume of the fluid. The system may be controllable to release collected fluid to another device, such as for assay and/or transport. The system may be configured to draw a liquid biological sample such as urine, and may include a fluid interface to draw fluid from a biological sample container.Type: ApplicationFiled: December 5, 2013Publication date: November 20, 2014Applicant: Boston MicrofluidicsInventors: Brandon T. JOHNSON, Kate E. CHRISTIAN, Glenn H. VERNER
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Patent number: 8846310Abstract: Methods of preparing assays and of assaying, using substantially self-contained, portable, user-initiated fluidic assay systems. Example assays include diagnostic assays and chemical detection assays. Diagnostic assays may include, without limitation, enzyme-linked immuno-sorbent assays (ELISA), and may include one or more sexually transmitted disease (STD) diagnostic assays. An assay system may include one or more fluid chambers, one or more fluid paths amongst the fluid chambers and/or between the fluid chambers, a sample portion, and/or an assay portion. The assay system may include a fluid controller system to dispense fluid from the one or more fluid chambers, and a user-initiated actuator to control the fluid controller system. The fluid controller system may be configured to dispense fluids serially, and may be configured to mix a plurality of fluids. The user-initiated actuator system may include an external user-operated trigger mechanism.Type: GrantFiled: August 15, 2011Date of Patent: September 30, 2014Assignee: Boston MicrofluidicsInventors: Brandon T. Johnson, Thomas M. Zappia, David A. Vogler
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Publication number: 20130309136Abstract: Sample processing methods and systems to collect and dilute a biological sample. A device collects a predetermined volume of sample in one chamber, seals the chamber upon activation, and mixes the sample with a predetermined volume of reagent.Type: ApplicationFiled: April 1, 2013Publication date: November 21, 2013Applicant: Boston MicrofluidicsInventors: Brandon T. Johnson, Kate E. Christian, Glen H. Verner, Daniel Morgan
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Publication number: 20110300563Abstract: Methods of preparing assays and of assaying, using substantially self-contained, portable, user-initiated fluidic assay systems. Example assays include diagnostic assays and chemical detection assays. Diagnostic assays may include, without limitation, enzyme-linked immuno-sorbent assays (ELISA), and may include one or more sexually transmitted disease (STD) diagnostic assays. An assay system may include one or more fluid chambers, one or more fluid paths amongst the fluid chambers and/or between the fluid chambers, a sample portion, and/or an assay portion. The assay system may include a fluid controller system to dispense fluid from the one or more fluid chambers, and a user-initiated actuator to control the fluid controller system. The fluid controller system may be configured to dispense fluids serially, and may be configured to mix a plurality of fluids. The user-initiated actuator system may include an external user-operated trigger mechanism.Type: ApplicationFiled: August 15, 2011Publication date: December 8, 2011Applicant: BOSTON MICROFLUIDICSInventors: Brandon T. Johnson, Tom Zappia, David A. Vogler
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Patent number: 8021873Abstract: Methods and systems to perform point-of-care, user-initiated fluidic assays, using substantially self-contained, portable, user-initiated fluidic assay systems. Exemplary assays include diagnostic assays and chemical detection assays. Diagnostic assays may include, without limitation, enzyme-linked immuno-sorbent assays (ELISA), and may include one or more sexually transmitted disease (STD) diagnostic assays. An exemplary assay system includes a housing having one or more fluid chambers, a fluid controller system to dispense fluid from the one or more fluid chambers, and a user-initiated actuator to control the fluid controller system. The actuator may be configured to move fluid controllers from functionally closed positions to functionally open positions, to control fluid flow from the fluid chambers. The fluid controller system may be configured to dispense fluids serially, and may be configured to mix a plurality of fluids.Type: GrantFiled: July 16, 2008Date of Patent: September 20, 2011Assignee: Boston MicrofluidicsInventors: Brandon T. Johnson, Tom Zappia, David A. Vogler
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Publication number: 20110152720Abstract: Methods and systems to prepare a sample, including a relatively small amount of a biological sample, and to mix the sample with preparation fluid stored in a device. The device may include multiple fluid chambers and a stepped plunger to force a fluid in at least one of the chambers into a sample receiving chamber and then to a storage chamber. Methods and systems disclosed herein may be implemented to collect and controllable mix a sample for analysis and/or storage.Type: ApplicationFiled: October 20, 2010Publication date: June 23, 2011Applicant: BOSTON MICROFLUIDICSInventors: Thomas M. Zappia, Brandon T. Johnson, David A. Vogler, Kate E. Christian
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Publication number: 20110151432Abstract: Methods and systems to related to sample collection, assays, and fluid control and management, including methods and systems to implement hand-held portable assays, to activate an assay system, to collect and prepare samples, to capture antibodies, and to trap or capture gas bubbles. Methods and systems disclosed herein, and portions thereof, may be implemented alone and/or in various combinations with one another.Type: ApplicationFiled: October 20, 2010Publication date: June 23, 2011Applicant: BOSTON MICROFLUIDICSInventors: Thomas M. Zappia, Brandon T. Johnson, Kate Christian, David Vogler, David Butz
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Publication number: 20110151486Abstract: Methods and systems to remove gas bubbles from liquids and to improve uniform fluid flow through a region of a membrane in a microfluidic device, including to reduce, remove, and/or prevent gas bubbles on a surface of a porous membrane. An example membrane bubble trap system may include a fluid channel connected to a bubble pathway that surrounds an opening sealed with a membrane. The bubble pathway may be configured to collect bubbles in fluid that passes through the membrane through buoyancy forces and through a directional feature of a curved surface placed above the membrane.Type: ApplicationFiled: October 20, 2010Publication date: June 23, 2011Applicant: Boston MicrofluidicsInventors: Thomas M. Zappia, Brandon T. Johnson, David Butz
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Publication number: 20110143335Abstract: Methods and systems to capture competitive molecules, such as to reduce false positives in an assay. Competitive molecules may be captured in a fluid moving through a portable point-of-care diagnostic assay system.Type: ApplicationFiled: October 20, 2010Publication date: June 16, 2011Applicant: BOSTON MICROFLUIDICSInventors: Brandon T. Johnson, Thomas M. Zappia, Kate E. Christian
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Publication number: 20110124129Abstract: Methods and systems to perform sequential user-controlled fluidic assays, using substantially self-contained, portable, user-initiated fluidic assay systems, including user-initiated activation methods and systems.Type: ApplicationFiled: October 20, 2010Publication date: May 26, 2011Applicant: BOSTON MICROFLUIDICSInventors: Thomas M. Zappia, Brandon T. Johnson, Kate E. Christian
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Patent number: D889684Type: GrantFiled: May 29, 2018Date of Patent: July 7, 2020Assignee: Boston Microfluidics, IncInventor: Brandon T. Johnson
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Patent number: D894422Type: GrantFiled: October 19, 2018Date of Patent: August 25, 2020Assignee: Boston Microfluidics, Inc.Inventor: Brandon T. Johnson
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Patent number: D899624Type: GrantFiled: October 19, 2018Date of Patent: October 20, 2020Assignee: Boston Microfluidics, Inc.Inventor: Brandon T. Johnson
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Patent number: D900336Type: GrantFiled: October 19, 2018Date of Patent: October 27, 2020Assignee: Boston Microfluidics, Inc.Inventor: Brandon T. Johnson
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Patent number: D910871Type: GrantFiled: October 19, 2018Date of Patent: February 16, 2021Assignee: Boston Microfluidics, Inc.Inventor: Brandon T. Johnson