Abstract: The present disclosure provides to generate a 3D visualization of a vessel from intravascular ultrasound (IVUS) images. In particular, the present disclosure provides to reduce jitter between frames of an IVUS recording to provide a smoother appearance of a longitudinal view of the vessel from the IVUS image frames and to construct a 3D visualization of the vessel from the jitter compensated IVUS image frames.

Abstract: A biopsy cap may be operatively connected to a port of a medical device. The biopsy cap seals a working channel that is configured to allow the passing of different diameter devices. During endoscopy procedures, the tip of many devices, such as guidewires and catheters, may be wetted before use to avoid excessive dragging forces when inserting such devices through the working channel of the endoscope. A cap system comprising a cap for a port of a first medical device; and a wetting device configured to couple to a portion of the cap and wet a second medical device passing through the cap system.

Abstract: The present disclosure relates generally to medical devices and procedures for placement of a medical device between adjacent tissue structures. In particular, the present disclosure relates to endoscopic systems and methods for preventing or minimizing movement between tissue walls to facilitate placement of a stent therebetween.

Abstract: A medical device includes a handle, a shaft, an end effector, and a wire. The handle includes a rotatable knob and a longitudinally movable spool. The shaft extends from a distal end of the handle. The end effector is coupled to a distal end of the shaft. The wire extends from the handle, through the shaft, and to the end effector. Rotation of the knob rotates the wire independent of the shaft to rotate the end effector. Distal movement of the spool moves the wire distally independent of the shaft and transitions the end effector between at least a first configuration and a second configuration. Proximal movement of the spool urges the wire proximally. Urging the wire proximally deflects a deflectable portion of the shaft in one or more directions.

Abstract: Intravascular imaging catheters and methods for making and using intravascular imaging catheters are disclosed. An example intravascular imaging catheter may include an elongate catheter shaft having a distal end region and a proximal region. A guidewire lumen may be defined in the elongate catheter shaft. The distal end region may include an imaging window defined by an open gap in the elongate catheter shaft. An imaging core may be disposed within the elongate catheter shaft. The imaging core may include an imaging device configured to be axially aligned with the imaging window.

Abstract: An endoscopic device includes a flexible shaft extending distally from a handle which, during use remains outside a living body, the shaft comprising a pull wire extending therethrough from the handle and a distal tip rotatably coupled to a distal end of the shaft, the distal tip comprising an imager directed distally from a distal face of the distal tip, the imager including a chip and a lens, a distal end of the pull wire being coupled to the distal tip in combination with an actuation mechanism coupled to a proximal end of the pull wire so that, actuation of the actuation mechanism, pulls the pull wire proximally through the shaft rotating the distal tip relative to the shaft to alter a field of view of the imager.

Abstract: The cleaning valves (or valves) of the current disclosure are generally single-use devices (SUDs) and therefore disposable. Reusing SUDs can be disadvantageous, as single-use devices are not designed to be reusable. Accordingly, valves for medical devices, such as endoscopes, disclosed may be configured to transition from a first state to a second state for indication of utilization of the valve, e.g., via exposure to a valve well. The transition from the first state to the second state may prevent reuse valves of the present disclosure. In embodiments, the valve may be made from a limited number of components and materials.

Abstract: An apparatus for treating a total occlusion in a blood vessel may include a self-orienting device including an elongate shaft and an inflatable orienting element. The shaft includes an inflation lumen having a first noncircular shape and a working lumen having a second noncircular shape. The inflatable orienting element includes first and second inflatable members extending laterally from the shaft. An outer diameter of the shaft is 0.045 inches or less, a cross-sectional area of the first noncircular cross-sectional shape is at least 0.00013 square inches, and a cross-sectional area of the second noncircular cross-sectional shape is at least 0.00056 square inches. The shaft may include a distal tail extending distally from the inflatable orienting element, the distal tail being at least 15 millimeters long. The shaft may include a plurality of first apertures communicating with the working lumen and disposed in the distal tail.

Abstract: A scope system includes a processor and a scope device. The scope device includes a handle configured to remain outside of the body and an elongated shaft extending from the handle to a distal tip and including a working channel extending therethrough. The working channel is open at the distal tip of the shaft. The shaft is inserted through a bodily lumen to a target surgical site. The shaft includes at least one sensor transmitting to the processor sensor data relating to the target surgical site.

Abstract: A device for fluidizing and delivering a powdered agent, including a canister extending longitudinally from a first to a second end and defining a space within which a powdered agent is received, an inlet coupleable to a gas source for supplying gas to the space to fluidize the powdered agent to create a fluidized mixture, an outlet via which the gas mixture is delivered to a target area, a tube extending from the outlet into the interior space, the tube including a slot extending through a wall thereof so that gas mixture is passable from the interior space through the outlet via the second end and the slot, and a door movably coupled to the tube so that the door is movable over the slot to control a size of the slot open to the interior space of the canister.

Abstract: A method for evaluating a gastrointestinal tract may include characterizing one or more disease parameters using objective measures obtained from imaging data of a gastrointestinal tract. The one or more disease parameters reflect a measure of at least one of lesions, ulcers, bleeding, stenosis, and vasculature. The method may also include using the one or more characterized disease parameters to classify a disease state.

Abstract: A device for treating tissue includes a catheter including an elongated body extending from a proximal end to a distal end and including a lumen extending therethrough, a distal tip connected to the distal end of the elongated body and including a first electrode and a second electrode extending thereabout, the first electrode extending to a distal opening of the lumen and a first needle extending longitudinally from a proximal end to a distal end, the first needle slidably received within the lumen of the catheter to be moved between a retracted bipolar configuration, in which the distal end of the needle is proximal the distal opening of the catheter, and an extended monopolar configuration, in which the distal end of the first needle extends distally past the distal opening of the catheter so that the first needle contacts the first electrode and is configured to cut tissue.

Abstract: In one aspect, the present disclosure pertains to elutable coating compositions that comprise an excipient comprising a bio-degradable or bio-stable polymer selected from a poly(lactic-co-glycolic acid) (PLGA) or methyl cellulose (MCC), a binding agent; a therapeutic agent. In some embodiments, the elutable coating compositions further comprise a solvent, in which case such compositions may be, for example, applied to a substrate in the form of a layer and subsequently dried, thereby forming an elutable coating on the substrate.

Abstract: A cryoballoon deflation assembly for an intravascular catheter system for use during a cryoablation procedure includes a first deflation initiator and a first deflation initiator inhibitor. The first deflation initiator is configured to automatically activate a vacuum pump to deflate a cryoballoon upon completion of a stage of the cryoablation procedure. The first deflation initiator inhibitor is manually changeable to between an activated and deactivated state. When in the activated state, the first deflation initiator inhibitor is configured to inactivate the first deflation initiator. The cryoballoon deflation assembly can further include a second deflation initiator. The second deflation initiator is manually changeable between an activated and deactivated state. When in the activated state, the second deflation initiator is triggered to activate the vacuum pump to deflate the cryoballoon.

Abstract: A pacing system configured to sense cardiac activity and to deliver pacing therapy to a patient's heart. The pacing system may comprise a first electrode configured to be positioned in a first chamber of the heart and configured to deliver a first pacing therapy to the first chamber of the heart and a second electrode configured to be positioned in the left atrial appendage and configured to deliver a second pacing therapy to the left atrial appendage. The processing module of the pacing system may be configured to time a delivery of the first pacing therapy based on a first timing fiducial and a delivery of the second pacing therapy based on a determined pacing delay between the first pacing therapy and the second pacing therapy. The determined pacing delay may be configured to maximize a flow of blood into and/or out of the left atrial appendage.

Abstract: Various embodiments are generally directed to devices, systems, and methods for controlling the flow of fluids in endoscopic systems, such as endoscopic ultrasound (EUS) enabled endoscopes. Some embodiments are particularly directed to valve sets and/or valve interface mechanisms for controlling air, water, and/or suction flow through a valve well for an endoscopic system. Several embodiments are directed to user interface mechanisms and techniques for enabling an operator to interact with and control endoscope valves. Many embodiments are directed to mechanisms and techniques for translating interface input motion into valve control motions. In one or more embodiments, the valve sets and/or valve interface mechanisms may be disposable.

Abstract: A medical device including a handle and a distal tip. The distal tip includes an elevator configured to change an orientation of an accessory device. The elevator is rotatable about a first axis and a second axis. Rotation of the elevator about the first axis raises or lowers the elevator. Rotation of the elevator about the second axis angles the elevator to the right or left. The medical device includes a first wire attached to a first side of the elevator and a second wire attached to a second side of the elevator. Moving the first wire and second wire the same distance proximally or distally relative to the distal tip rotates the elevator about the first axis. Moving one of the first wire and second wire a distance relative to the other of the first wire and second wire rotates the elevator about the second axis.

Abstract: A tissue lumen stent is provided with a body having an elongated tubular configuration and a foreshortened configuration. In the foreshortened configuration, downstream and upstream ends of the body expand radially into downstream and upstream flange structures, leaving a generally cylindrical saddle region therebetween. In some embodiments, the flange structures are non-symmetrical with respect to one another. Systems and methods of using the stents are also disclosed.

Abstract: A catheter includes a handle and an elongate member extending from the handle. The catheter may also include steering system coupled to the handle. The steering system may be configured to deflect at least a portion of the elongate member in at least one direction. The catheter may also include a locking mechanism configured to lock the portion of the elongate member in a deflected configuration, and a lever coupled to the handle. The lever may be configured to move from a first position to a second position to engage the locking mechanism. The lever may also be configured to be separably retained at least at one of the first position or the second position to prevent movement therebetween.

Abstract: Electronic assemblies for medical devices are described, including an electronic assembly that includes a body, at least one imaging device, and at least one light source. The body may include a plurality of electrical connection points and a plurality of electrical traces in a material that is electrically insulative. The plurality of electrical connection points may be on one or more external surfaces of the body. The plurality of electrical connection points may include proximal and distal connection points. Each electrical trace may connect a proximal connection point to a respective distal connection point. The at least one imaging device may be coupled to one or more of the distal connection points and/or the at least one light source may be coupled to one or more of the distal connection points.