Abstract: A delivery system for delivering, adjusting, and/or recapturing a stent-valve includes an inner shaft and an expandable stent-valve coupled to the inner shaft. The stent-valve has an upper portion, a lower portion, and a valve. The delivery system also includes a distal sheath disposed over at least the lower portion, a proximal sheath disposed over at least the upper portion, and at least one cinching member coupled to the stent-valve and extending through one of the inner shaft, the distal sheath, or the proximal sheath. The upper and lower portions of the stent-valve are configured to move to an expanded configuration when the proximal and distal sheaths are withdrawn, respectively. After at least a portion of the stent-valve has been moved to the expanded configuration, the at least one cinching member is configured to at least partially radially compress at least a portion of the stent-valve.

Abstract: A thrombectomy apparatus includes a funnel that is secured to a distal end of a catheter. The funnel includes a braided inner layer, a braided outer layer and a reinforcing structure disposed therebetween. The reinforcing structure includes a tubular metal member and a plurality of fingers extending distally from the tubular metal member. Each finger defines two or more pockets. Each of two or more rings extend through a pocket of each of the plurality of fingers, the pockets limiting axial movement of each of the two or more rings. A tractor is adapted to extend over the outer surface of the catheter and the funnel in an un-inverted configuration and to extend in an inverted configuration through the funnel and into the lumen. An elongate member extends through the lumen and is secured to an end of the tractor disposed within the lumen.

Abstract: A medical system may comprise an endoscope, including a handle and a sheath having a first illumination source, a second illumination source, and an imaging device at a distal tip of the sheath. The first illumination source may be configured to emit white light. The second illumination source may be configured to emit a non-white light. The system may also comprise a display device, a controller configured to interface with the endoscope and the display device, and a carrying case configured to contain the endoscope, the display device, and the controller.

Abstract: A medical device includes a sheath extending longitudinally from a proximal end to a distal end and a handle coupled to the proximal end of the sheath. The handle includes a deflection lever coupled thereto. The deflection lever is rotatable proximally and distally along the handle to deflect a distal end of the shaft to which it is operably coupled and a locking mechanism movable between an locked configuration in which the locking mechanism engages an engagement feature on the outer surface of the handle, preventing the deflection lever from rotating and locking the distal end of the shaft in a desired position, and an unlocked configuration in which the locking mechanism releases the engagement feature to allow rotation of the deflection lever and deflection of the distal end of the shaft.

Abstract: A method for coupling a first medical device component to a second medical device component comprising altering the first medical device component from a natural state to an altered state, by reducing a cross-sectional dimension of the first medical device, fitting a first portion of the first medical device component in the altered state into a first opening of the second medical device component, wherein the first medical device component includes second portions not within the first opening of the second medical device component, and allowing the second portions of the first medical device component to revert back to the natural state.

Abstract: The invention discloses an implant. The implant may include a first flap and a second flap. The first flap may further include a first portion, a second portion and a transition region. The first portion may be configured to be attached proximate a sacrum. The second portion may be configured to be attached to an anterior vaginal wall. The transition region lies between the first portion and the second portion. The second flap may be fabricated such that a portion of the second flap is configured to be attached to a posterior vaginal wall. The implant may be configured such that a value corresponding to a biomechanical parameter defining a biomechanical attribute of the portion of the first flap attaching to the anterior wall is different from a value of the biomechanical parameter defining the biomechanical attribute of the portion of the second flap attaching to the posterior wall.

Abstract: A pancreatic stent includes a main body convertible between a compressed configuration for delivery and an expanded configuration once deployed, the main body including an inner surface defining a stent lumen and an outer surface. A plurality of drainage features are formed within the outer surface of the main body, the plurality of drainage features permitting placement of the pancreatic stent within a patient's pancreas without blocking side branches of the pancreas.

Abstract: This disclosure relates generally to the field of devices and procedures for forming an opening between adjacent tissue structures. For example, in an embodiment, a system for forming an opening between body lumens may include a delivery catheter. A first access element may be configured to be positioned against a first body lumen disposed about a distal end of the catheter. A second access element having an outer diameter that substantially matches an outer diameter of the first access element may be disposed about the distal end of the catheter. The second access element may be configured to be positioned against a second body lumen and axially aligned with the first access element. A filament may be electrically coupled to one or both of the first and second access element.

Abstract: A device for occluding flow of materials is formed as a simple structure permitting a compact delivery configuration which may shift to an expanded deployment configuration. The device has at least one expandable portion formed of a plurality of elongated longitudinally extending frame elements. The frame elements may be spaced apart to define spaces therebetween, and a flexible occlusive material may be provided to block flow of material through such spaces. A flexible occlusive material may form one of two expandable portions of the device without the need for frame elements.

Abstract: Systems, apparatuses, and methods for electroporation ablation therapy are disclosed, with a protection device for protecting electronic circuitry, devices, and/or other components from induced currents and voltages generated during a cardiac ablation procedure. A system can include an ablation device near cardiac tissue of a heart. The system can further include a signal generator configured to generate a pulse waveform, where the signal generator coupled to the ablation device and configured to repeatedly deliver the pulse waveform to the ablation device in synchrony with a set of cardiac cycles of the heart. The system can further include a protection device configured to suppress induced current and voltage in an electronic device coupled to the protection device.

Abstract: Methods and compositions are disclosed herein to define a suite of shear-thinning hydrogels exhibiting piezoelectric properties. The piezoelectric materials described can be injected percutaneously or via transcatheter vascular route into a target environment for the locoregional stimulation of cells or tissues using wireless impulses as actuation mechanisms. These external stimuli introduce either an electrical or mechanical response in the implanted piezoelectric materials for medical interventions including tumor ablation, drug delivery, electroporation, chemo-electroporation, neural stimulation, wound healing, cardiovascular applications and musculoskeletal pain management.

Abstract: Medical devices and related methods are described, including a medical device that includes a tubular assembly including a plurality of tubes. Each tube of the plurality of tubes may be configured to be coupled to a vacuum source to deliver negative pressure to a distal end of each respective tube of the plurality of tubes. The medical device may further include a porous assembly including a plurality of sections and may be coupled to a distal end of the tubular assembly. Each section of the plurality of sections may be coupled to a respective tube of the plurality of tubes.

Abstract: A circulatory support system may include a blood pump and a controller. The blood pump may include a driven component and a motor in communication with the driven component and the controller to drive the driven component to pump a blood flow through the blood pump. The controller may be configured to receive a value of a circulatory parameter related to blood flow through a patient, determine a value of a command signal based on the received value, and output the command signal to the motor to drive the driven component at a speed configured to achieve the value of the circulator parameter related to blood flow through the patient.

Abstract: A circulatory support system may include a blood pump, one or more sensors, and a controller in communication with the one or more sensors. The blood pump may include a driven component and a motor in communication with the driven component to drive the driven component to pump a blood flow through the blood pump. A sensor of the one or more sensors may be configured to sense a value related to a speed of the motor. The controller may be configured to provide a command signal to the motor to drive the driven component and determine a rate of hemolysis during operation of the blood pump based on an operation parameter of the blood pump.

Abstract: A rotational atherectomy device advanceable over a guidewire. The rotational atherectomy device includes a drive shaft rotatably extending through an outer tubular member to rotate a cutting member positioned at a distal end thereof. The rotational atherectomy device further includes an insert positioned within the cutting member for frictional contact with the guidewire.

Abstract: A medical device comprising a shaft, a handle housing a proximal end of the shaft, a first channel extending throughout a lumen of the shaft, wherein the first channel is rotatable about a longitudinal axis of the shaft, the channel including a proximal end and a distal end, and an actuator, wherein a distal end of the actuator is configured to engage and disengage with the proximal end of the first channel, such that in an engaged position the actuator and the first channel are rotatable.

Abstract: A circulatory support system may include a blood pump, one or more sensors, and a controller. The blood pump may include a driven component and a motor in communication with the driven component and the controller to drive the driven component to pump a blood flow through the blood pump. The controller may be configured to determine a command signal based on a value related to a speed of the motor, provide the command signal to the motor to drive the driven component, determine a value of a parameter related to operation of the blood pump based on the command signal and the value related to the speed of the motor, and output an indication a blood pump transition is recommended based on one or more determined values of one or more parameters related to operation of the blood pump.

Abstract: Methods and systems providing fluid flow to an endoscope. A container and tube set configured to couple to an endoscope may comprise a first container configured to contain a fluid, a first water supply tube including a first lumen extending therethrough and in fluid communication with the first container, a branched connector positioned in line with the first water supply tube and including a first fluid inlet, a first fluid outlet, and a second fluid outlet, a second container having a second fluid inlet in selective fluid communication with the second fluid outlet of the branched connector, a flow control valve positioned to obstruct flow between the second fluid outlet of the branched connector and the second fluid inlet of the second container, and a second water supply tube including a second lumen extending therethrough and in selective fluid communication with the bottom portion of the second container.

Abstract: Medical devices as wells as methods for making and using medical devices are disclosed. An example medical device may include a left atrial appendage device. The occlusive medical device includes an expandable frame configured to shift between a first configuration and an expanded configuration and a fabric disposed along at least a portion of the expandable frame. A drug eluting coating is disposed on the fabric, the drug eluting coating including a pharmaceutically active component dispersed within a polymeric carrier.

Abstract: A pancreatic stent includes a main body convertible between a compressed configuration for delivery and an expanded configuration once deployed, the main body including an inner surface defining a stent lumen and an outer surface. A plurality of drainage features are formed within the outer surface of the main body, the plurality of drainage features permitting placement of the pancreatic stent within a patient's pancreas without blocking side branches of the pancreas.