Abstract: A cocrystal containing the 1?R-diastereomer and the 1?S-diastereomer of sofpironium bromide at a ratio of 1:3 (Form CO), a crystal mixture (for example, Form B) containing Form CO and a crystalline form of the 1?R-diastereomer (Form MN), and a method for preparing sofpironium bromide, which is suitable for manufacture of the crystal mixture are provided. Form CO and a crystalline form of sofpironium bromide containing Form CO (for example, Form B) have superior stability without hygroscopic property, and accordingly they can be preferably used as a raw material of medicaments.
Type:
Grant
Filed:
June 30, 2021
Date of Patent:
February 21, 2023
Assignee:
Botanix SB, Inc.
Inventors:
Kazuyoshi Marubayashi, Masahito Watanabe, Herbert R. Brinkman
Abstract: A cocrystal containing the 1?R-diastereomer and the 1'S-diastereomer of sofpironium bromide at a ratio of 1:3 (Form CO), a crystal mixture (for example, Form B) containing Form CO and a crystalline form of the 1?R-diastereomer (Form MN), and a method for preparing sofpironium bromide, which is suitable for manufacture of the crystal mixture are provided. Form CO and a crystalline form of sofpironium bromide containing Form CO (for example, Form B) have superior stability without hygroscopic property, and accordingly they can be preferably used as a raw material of medicaments.
Type:
Grant
Filed:
November 25, 2020
Date of Patent:
January 31, 2023
Assignee:
Botanix SB, Inc.
Inventors:
Kazuyoshi Marubayashi, Masahito Watanabe, Herbert R. Brinkman
© 2024 Justia
