Abstract: Antibacterial compounds of the following formula ##STR1## where the variables are as in claim 1 and their pharmaceutically acceptable bases.

Abstract: A method of treating bacterial infections in warm-blooded animals comprising administering to warm-blooded animals an antibactericidally effective amount of at least one compound of the formula ##STR1## wherein R is ##STR2## Y is selected from the group consisting of lower alkyl, lower alkenyl, phenyl optionally substituted with 1 to 3 members of the group consisting of halogen, lower alkyl, --NO.sub.2, --CF.sub.3 and alkoxy carbonyl, X is oxygen and R.sub.1 is selected from the group consisting of methyl, fluoromethyl, vinyl, phenyl and ##STR3## wherein Z is halogen and p is 1, 2 or 3 and its non-toxic, pharmaceutically acceptable salts with a base or acid.

Abstract: This invention relates to novel tri-substituted guanidines linked to a piperidine ring.More specifically, it relates to cyanoguanidines of formula I ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 are substituentsn is an integer of zero to 1n' is an integer of zero to 1A and B are --CH.sub.2 --, CHOH, --CO-- or a single bondas well as the acid addition salts thereof with a mineral or organic acid.The compounds have interesting pharmacological properties which make them useful as active ingredient of medicines, e.g. antihypertensives.